File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Study of rare earth encapsulated carbon nanomolecules for biomedical uses

TitleStudy of rare earth encapsulated carbon nanomolecules for biomedical uses
Authors
KeywordsGd-Metallofullerenol
Gd@C82(Oh)22
In Vivo
Mri Contrast Agent
Stability
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jallcom
Citation
Journal of Alloys and Compounds, 2006, v. 408-412, p. 400-404 How to Cite?
AbstractGd@C82(OH)40 has been proposed to be as a new generation of the magnetic resonance imaging (MRI) contrast agent, but water-soluble fullerenols Gd@C82(OH)n with n > 36 can easily lead to open-caged structures of a high instability. This restricts the practical bio-uses of Gd-metallofullerenols with a large number of hydroxyl groups. To explore how the imaging efficiency varies with decreasing hydroxyl number in Gd@C82(OH)n of a good stability in vivo, Gd@C82(OH)22 was prepared, characterized and its imaging efficiency in mice was studied. This work aims at searching a chemical form of water-soluble Gd-metallofullerenols that satisfy both requirements of the good stability and high imaging efficiency in vivo. The results indicate that the proton relaxivity of Gd@C82(OH)22 is lower than that of Gd@C82(OH)40, but still higher than the commercial Gd-DTPA MRI contrast agent. © 2005 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/91288
ISSN
2015 Impact Factor: 3.014
2015 SCImago Journal Rankings: 1.006
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQu, Len_HK
dc.contributor.authorCao, Wen_HK
dc.contributor.authorXing, Gen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorYuan, Hen_HK
dc.contributor.authorTang, Jen_HK
dc.contributor.authorCheng, Yen_HK
dc.contributor.authorZhang, Ben_HK
dc.contributor.authorZhao, Yen_HK
dc.contributor.authorLei, Hen_HK
dc.date.accessioned2010-09-17T10:16:15Z-
dc.date.available2010-09-17T10:16:15Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal of Alloys and Compounds, 2006, v. 408-412, p. 400-404en_HK
dc.identifier.issn0925-8388en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91288-
dc.description.abstractGd@C82(OH)40 has been proposed to be as a new generation of the magnetic resonance imaging (MRI) contrast agent, but water-soluble fullerenols Gd@C82(OH)n with n > 36 can easily lead to open-caged structures of a high instability. This restricts the practical bio-uses of Gd-metallofullerenols with a large number of hydroxyl groups. To explore how the imaging efficiency varies with decreasing hydroxyl number in Gd@C82(OH)n of a good stability in vivo, Gd@C82(OH)22 was prepared, characterized and its imaging efficiency in mice was studied. This work aims at searching a chemical form of water-soluble Gd-metallofullerenols that satisfy both requirements of the good stability and high imaging efficiency in vivo. The results indicate that the proton relaxivity of Gd@C82(OH)22 is lower than that of Gd@C82(OH)40, but still higher than the commercial Gd-DTPA MRI contrast agent. © 2005 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jallcomen_HK
dc.relation.ispartofJournal of Alloys and Compoundsen_HK
dc.subjectGd-Metallofullerenolen_HK
dc.subjectGd@C82(Oh)22en_HK
dc.subjectIn Vivoen_HK
dc.subjectMri Contrast Agenten_HK
dc.subjectStabilityen_HK
dc.titleStudy of rare earth encapsulated carbon nanomolecules for biomedical usesen_HK
dc.typeArticleen_HK
dc.identifier.emailCheng, Y:yuecheng@hku.hken_HK
dc.identifier.authorityCheng, Y=rp1320en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jallcom.2004.12.101en_HK
dc.identifier.scopuseid_2-s2.0-31144451715en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-31144451715&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume408-412en_HK
dc.identifier.spage400en_HK
dc.identifier.epage404en_HK
dc.identifier.isiWOS:000235445300097-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats