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Article: A functional investigation of tumor suppressor gene activities in a nasopharyngeal carcinoma cell line HONE1 using a monochromosome transfer approach

TitleA functional investigation of tumor suppressor gene activities in a nasopharyngeal carcinoma cell line HONE1 using a monochromosome transfer approach
Authors
KeywordsSpecies Index: Animalia
Mus Musculus
Issue Date2000
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250
Citation
Genes Chromosomes And Cancer, 2000, v. 28 n. 1, p. 82-91 How to Cite?
AbstractMonochromosome transfers of selected chromosomes into a nasopharyngeal carcinoma (NPC) cell line were performed to determine if tumor suppressing activity for NPC mapped to chromosomes 9, 11, and 17. Current information from cytogenetic and molecular allelotyping studies indicate that these chromosomes may harbor potential tumor suppressor genes vital to NPC. The present results show the importance of CDKN2A on chromosome 9 in NPC development. There was no functional suppression of tumor development in nude mice with microcell hybrids harboring the newly transferred chromosome 9 containing an interstitial deletion at 9p21, whereas transfection of CDKN2A into the NPC HONE1 cells resulted in obvious growth suppression. Whereas intact chromosome 17 transfers into HONE1 cells showed no functional suppression of tumor formation, chromosome 11 was able to do so. Molecular analysis of chromosome 11 tumor segregants indicated that at least two tumor suppressive regions mapping to 11q13 and 11q22-23 may be critical for the development of NPC. (C) 2000 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/91279
ISSN
2015 Impact Factor: 3.96
2015 SCImago Journal Rankings: 2.210
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, Yen_HK
dc.contributor.authorStanbridge, EJen_HK
dc.contributor.authorKong, Hen_HK
dc.contributor.authorBengtsson, Uen_HK
dc.contributor.authorLerman, MIen_HK
dc.contributor.authorLung, MLen_HK
dc.date.accessioned2010-09-17T10:16:06Z-
dc.date.available2010-09-17T10:16:06Z-
dc.date.issued2000en_HK
dc.identifier.citationGenes Chromosomes And Cancer, 2000, v. 28 n. 1, p. 82-91en_HK
dc.identifier.issn1045-2257en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91279-
dc.description.abstractMonochromosome transfers of selected chromosomes into a nasopharyngeal carcinoma (NPC) cell line were performed to determine if tumor suppressing activity for NPC mapped to chromosomes 9, 11, and 17. Current information from cytogenetic and molecular allelotyping studies indicate that these chromosomes may harbor potential tumor suppressor genes vital to NPC. The present results show the importance of CDKN2A on chromosome 9 in NPC development. There was no functional suppression of tumor development in nude mice with microcell hybrids harboring the newly transferred chromosome 9 containing an interstitial deletion at 9p21, whereas transfection of CDKN2A into the NPC HONE1 cells resulted in obvious growth suppression. Whereas intact chromosome 17 transfers into HONE1 cells showed no functional suppression of tumor formation, chromosome 11 was able to do so. Molecular analysis of chromosome 11 tumor segregants indicated that at least two tumor suppressive regions mapping to 11q13 and 11q22-23 may be critical for the development of NPC. (C) 2000 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250en_HK
dc.relation.ispartofGenes Chromosomes and Canceren_HK
dc.subjectSpecies Index: Animaliaen_HK
dc.subjectMus Musculusen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshChromosomes, Human, Pair 11 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 17 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 9 - geneticsen_HK
dc.subject.meshCyclin-Dependent Kinase Inhibitor p16 - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Transfer Techniquesen_HK
dc.subject.meshGenes, Tumor Suppressor - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred BALB Cen_HK
dc.subject.meshMice, Nudeen_HK
dc.subject.meshNasopharyngeal Neoplasms - geneticsen_HK
dc.subject.meshTransfectionen_HK
dc.subject.meshTumor Cells, Cultureden_HK
dc.subject.meshTumor Stem Cell Assayen_HK
dc.subject.meshTumor Suppressor Protein p53 - biosynthesis - geneticsen_HK
dc.titleA functional investigation of tumor suppressor gene activities in a nasopharyngeal carcinoma cell line HONE1 using a monochromosome transfer approachen_HK
dc.typeArticleen_HK
dc.identifier.emailCheng, Y:yuecheng@hku.hken_HK
dc.identifier.emailLung, ML:mlilung@hku.hken_HK
dc.identifier.authorityCheng, Y=rp01320en_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1098-2264(200005)28:1<82::AID-GCC10>3.0.CO;2-8en_HK
dc.identifier.pmid10738306-
dc.identifier.scopuseid_2-s2.0-0034077140en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034077140&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue1en_HK
dc.identifier.spage82en_HK
dc.identifier.epage91en_HK
dc.identifier.isiWOS:000086120200010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, Y=36131038300en_HK
dc.identifier.scopusauthoridStanbridge, EJ=7103249410en_HK
dc.identifier.scopusauthoridKong, H=36808058200en_HK
dc.identifier.scopusauthoridBengtsson, U=7005608839en_HK
dc.identifier.scopusauthoridLerman, MI=24356375900en_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK

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