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Article: Association of EGFR gene fragments with nuclear matrices in glioblastoma cell lines

TitleAssociation of EGFR gene fragments with nuclear matrices in glioblastoma cell lines
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1998
PublisherInternational Institute of Anticancer Research
Citation
Anticancer Research, 1998, v. 18 n. 6 A, p. 4329-4332 How to Cite?
AbstractThe association of epidermal growth factor receptor DNA fragments with nuclear matrix in glioblastoma cell lines was investigated. Two different DNA fragments (primer I-III, 940 bp and primer IV-V, 110 bp) were amplified in both genomic DNA and nuclear matrix-associated DNA. It was found that the 110 bp DNA fragment (primer IV-V) from a non-encoding region was more closely associated with the nuclear matrices of cell line U343, U373, A172, and T98 than with U87. The other DNA fragment (primer I-III) was found in both the genomic DNA and NM DNA from cell line of U343 and U87. Another long DNA fragment (primer I-II, 1015 bp) was not detected in the DNA of all cell lines. Our findings suggest that the attachment of the 110 bp DNA fragments to nuclear matrix may contribute to the growth and malignancy of gliblastoma.
Persistent Identifierhttp://hdl.handle.net/10722/91277
ISSN
2015 Impact Factor: 1.895
2015 SCImago Journal Rankings: 0.815
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, ZHen_HK
dc.contributor.authorTian, XXen_HK
dc.contributor.authorCheng, Yen_HK
dc.contributor.authorYam, GHFen_HK
dc.contributor.authorNg, HKen_HK
dc.contributor.authorDing, MXen_HK
dc.contributor.authorChew-Cheng, SBen_HK
dc.contributor.authorChew, ECen_HK
dc.date.accessioned2010-09-17T10:16:05Z-
dc.date.available2010-09-17T10:16:05Z-
dc.date.issued1998en_HK
dc.identifier.citationAnticancer Research, 1998, v. 18 n. 6 A, p. 4329-4332en_HK
dc.identifier.issn0250-7005en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91277-
dc.description.abstractThe association of epidermal growth factor receptor DNA fragments with nuclear matrix in glioblastoma cell lines was investigated. Two different DNA fragments (primer I-III, 940 bp and primer IV-V, 110 bp) were amplified in both genomic DNA and nuclear matrix-associated DNA. It was found that the 110 bp DNA fragment (primer IV-V) from a non-encoding region was more closely associated with the nuclear matrices of cell line U343, U373, A172, and T98 than with U87. The other DNA fragment (primer I-III) was found in both the genomic DNA and NM DNA from cell line of U343 and U87. Another long DNA fragment (primer I-II, 1015 bp) was not detected in the DNA of all cell lines. Our findings suggest that the attachment of the 110 bp DNA fragments to nuclear matrix may contribute to the growth and malignancy of gliblastoma.en_HK
dc.languageengen_HK
dc.publisherInternational Institute of Anticancer Researchen_HK
dc.relation.ispartofAnticancer Researchen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleAssociation of EGFR gene fragments with nuclear matrices in glioblastoma cell linesen_HK
dc.typeArticleen_HK
dc.identifier.emailCheng, Y:yuecheng@hku.hken_HK
dc.identifier.authorityCheng, Y=rp1320en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9891487-
dc.identifier.scopuseid_2-s2.0-0032410323en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032410323&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue6 Aen_HK
dc.identifier.spage4329en_HK
dc.identifier.epage4332en_HK
dc.identifier.isiWOS:000078056000055-

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