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Article: Chromosome 13q12 region critical for the viability and growth of nasopharyngeal carcinoma hybrids

TitleChromosome 13q12 region critical for the viability and growth of nasopharyngeal carcinoma hybrids
Authors
KeywordsReferences (40) View In Table Layout
Issue Date2004
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 2004, v. 109 n. 3, p. 357-362 How to Cite?
AbstractAllelic losses of chromosome 13 are often detected in nasopharyngeal carcinoma (NPC) and other cancers, implicating the presence of possible tumor suppressor genes (TSGs) on this chromosome. To identify candidate regions from larger and multiple lost areas observed from direct tumor studies, the technique of monochromosome transfer was utilized to provide functional evidence to verify and define these deletion findings. An intact chromosome 13 was transferred into the NPC HONE1 cell line. Resultant hybrids were used to map putative TSG activity. A critical region at 13q12 was non-randomly eliminated in all surviving microcell hybrids around the marker D13S893; these hybrids were uniformly tumorigenic. Although a known TSG, BRCA2, is mapped close to this critical region, no aberrant expression of this gene was detected in microcell hybrids and other NPC cell lines. These results suggest that at least one novel growth control gene on chromosome 13q12, which is not the BRCA2 gene, is essential for hybrid selection and may play a critical role in tumorigenicity. © 2004 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/91275
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, Yen_HK
dc.contributor.authorLung, HLen_HK
dc.contributor.authorWong, PSen_HK
dc.contributor.authorHao, DCen_HK
dc.contributor.authorMan, CSen_HK
dc.contributor.authorStanbridge, EJen_HK
dc.contributor.authorLungi, MLen_HK
dc.date.accessioned2010-09-17T10:16:03Z-
dc.date.available2010-09-17T10:16:03Z-
dc.date.issued2004en_HK
dc.identifier.citationInternational Journal Of Cancer, 2004, v. 109 n. 3, p. 357-362en_HK
dc.identifier.issn0020-7136en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91275-
dc.description.abstractAllelic losses of chromosome 13 are often detected in nasopharyngeal carcinoma (NPC) and other cancers, implicating the presence of possible tumor suppressor genes (TSGs) on this chromosome. To identify candidate regions from larger and multiple lost areas observed from direct tumor studies, the technique of monochromosome transfer was utilized to provide functional evidence to verify and define these deletion findings. An intact chromosome 13 was transferred into the NPC HONE1 cell line. Resultant hybrids were used to map putative TSG activity. A critical region at 13q12 was non-randomly eliminated in all surviving microcell hybrids around the marker D13S893; these hybrids were uniformly tumorigenic. Although a known TSG, BRCA2, is mapped close to this critical region, no aberrant expression of this gene was detected in microcell hybrids and other NPC cell lines. These results suggest that at least one novel growth control gene on chromosome 13q12, which is not the BRCA2 gene, is essential for hybrid selection and may play a critical role in tumorigenicity. © 2004 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_HK
dc.relation.ispartofInternational Journal of Canceren_HK
dc.subjectReferences (40) View In Table Layouten_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Divisionen_HK
dc.subject.meshCell Survivalen_HK
dc.subject.meshChromosome Deletionen_HK
dc.subject.meshChromosomes, Human, Pair 13 - physiologyen_HK
dc.subject.meshGene Dosageen_HK
dc.subject.meshGene Transfer Techniquesen_HK
dc.subject.meshGenes, Tumor Suppressoren_HK
dc.subject.meshHumansen_HK
dc.subject.meshHybrid Cellsen_HK
dc.subject.meshIn Situ Hybridization, Fluorescenceen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMicrosatellite Repeats - geneticsen_HK
dc.subject.meshNasopharyngeal Neoplasms - genetics - pathologyen_HK
dc.subject.meshTumor Cells, Cultureden_HK
dc.titleChromosome 13q12 region critical for the viability and growth of nasopharyngeal carcinoma hybridsen_HK
dc.typeArticleen_HK
dc.identifier.emailCheng, Y:yuecheng@hku.hken_HK
dc.identifier.emailLung, HL:hllung2@hku.hken_HK
dc.identifier.authorityCheng, Y=rp01320en_HK
dc.identifier.authorityLung, HL=rp00299en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ijc.11704en_HK
dc.identifier.pmid14961573-
dc.identifier.scopuseid_2-s2.0-1342267077en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1342267077&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume109en_HK
dc.identifier.issue3en_HK
dc.identifier.spage357en_HK
dc.identifier.epage362en_HK
dc.identifier.isiWOS:000189245300007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, Y=36131038300en_HK
dc.identifier.scopusauthoridLung, HL=6603819904en_HK
dc.identifier.scopusauthoridWong, PS=7403979959en_HK
dc.identifier.scopusauthoridHao, DC=7005159211en_HK
dc.identifier.scopusauthoridMan, CS=7005722366en_HK
dc.identifier.scopusauthoridStanbridge, EJ=7103249410en_HK
dc.identifier.scopusauthoridLungi, ML=6506293498en_HK

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