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Article: Human DNA oncogenic viruses and their transforming protein interactions with cell cycle control proteins

TitleHuman DNA oncogenic viruses and their transforming protein interactions with cell cycle control proteins
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1999
PublisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 1999, v. 112 n. 4, p. 291-296 How to Cite?
AbstractPurpose Both oncogenic viruses and cell cycle control proteins are fast-growth research areas. More and more evidence indicates that virus infection and replication are often associated with apoptosis and interfere with cell cycle pathways. To understand the mechanisms by which viral proteins regulate apoptosis and target the cellular pathways may lead to the development of new remedies for some cancers. Data sources English literature searched by MEDLINE from January 1995 to August 1998. Study selection and data extraction More than one hundred research papers published in these areas over the past three years. Only new and important breakthroughs in these papers are selected. The review focuses on DNA viruses associated with the development of human cancers. Results and conclusions Some DNA viruses contain oncogenic proteins which transform normal cells in vitro and induce tumors in animals. These viral proteins target the cellular pathways and block apoptosis induced by receptors or in response to signal transduction. Viral interference with host cell apoptosis leads to enhanced viral replication and may promote carcinogenesis. Oncogenes and tumor suppressor genes, such as Retinoblastoma (RB) and p53, play important roles in regulation of these interactions.
Persistent Identifierhttp://hdl.handle.net/10722/91261
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, Yen_HK
dc.date.accessioned2010-09-17T10:15:49Z-
dc.date.available2010-09-17T10:15:49Z-
dc.date.issued1999en_HK
dc.identifier.citationChinese Medical Journal, 1999, v. 112 n. 4, p. 291-296en_HK
dc.identifier.issn0366-6999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91261-
dc.description.abstractPurpose Both oncogenic viruses and cell cycle control proteins are fast-growth research areas. More and more evidence indicates that virus infection and replication are often associated with apoptosis and interfere with cell cycle pathways. To understand the mechanisms by which viral proteins regulate apoptosis and target the cellular pathways may lead to the development of new remedies for some cancers. Data sources English literature searched by MEDLINE from January 1995 to August 1998. Study selection and data extraction More than one hundred research papers published in these areas over the past three years. Only new and important breakthroughs in these papers are selected. The review focuses on DNA viruses associated with the development of human cancers. Results and conclusions Some DNA viruses contain oncogenic proteins which transform normal cells in vitro and induce tumors in animals. These viral proteins target the cellular pathways and block apoptosis induced by receptors or in response to signal transduction. Viral interference with host cell apoptosis leads to enhanced viral replication and may promote carcinogenesis. Oncogenes and tumor suppressor genes, such as Retinoblastoma (RB) and p53, play important roles in regulation of these interactions.en_HK
dc.languageengen_HK
dc.publisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/en_HK
dc.relation.ispartofChinese Medical Journalen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshCell Cycle Proteins - metabolismen_HK
dc.subject.meshDNA Viruses - pathogenicityen_HK
dc.subject.meshHepacivirus - pathogenicityen_HK
dc.subject.meshHepatitis B virus - pathogenicityen_HK
dc.subject.meshHumansen_HK
dc.subject.meshOncogene Proteins, Viral - metabolismen_HK
dc.subject.meshOncogenic Viruses - pathogenicityen_HK
dc.subject.meshPapillomaviridae - pathogenicityen_HK
dc.titleHuman DNA oncogenic viruses and their transforming protein interactions with cell cycle control proteinsen_HK
dc.typeArticleen_HK
dc.identifier.emailCheng, Y:yuecheng@hku.hken_HK
dc.identifier.authorityCheng, Y=rp01320en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid11593524en_HK
dc.identifier.scopuseid_2-s2.0-0033108241en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033108241&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume112en_HK
dc.identifier.issue4en_HK
dc.identifier.spage291en_HK
dc.identifier.epage296en_HK
dc.identifier.isiWOS:000079777400001-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridCheng, Y=36131038300en_HK

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