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Article: Determination of peroxide value in sirolimus oral solution by potentiometric-iodometry

TitleDetermination of peroxide value in sirolimus oral solution by potentiometric-iodometry
Authors
KeywordsDetermination
Iodometry
Peroxide Value
Potentiometry
Issue Date2003
Citation
Chinese Journal of Antibiotics, 2003, v. 28 n. 9, p. 532-533+S2 How to Cite?
AbstractObjective: To develop a method for the determination of peroxide value in sirolimus oral solution. Methods: A potentiometric - iodometry method was conducted. Sirolimus was dissolved in methanol, and excess volume of iodine titrant was added. The titration was carried out using (Chinese characters S2 Chinese characters) (Chinese characters 540 Chinese characters) Mettler DL67 automatic titrator with 0. 01mol/L sodium thiosulphate as blank titrant to reach the endpoint, with Mettler DM140-SC Electrode as potential indicator. In order to acquire the net content of peroxide value in oral solution, a blank determination was performed. Results: The method showed a smooth titration curve, high sensitivity and good reproducibility. Conclusions: The method was convenient and accurate. It provided a suitable method to determine the peroxide value in sirolimus oral solution.
Persistent Identifierhttp://hdl.handle.net/10722/91253
ISSN
2015 SCImago Journal Rankings: 0.103
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, Yen_HK
dc.contributor.authorHong, L-Yen_HK
dc.date.accessioned2010-09-17T10:15:41Z-
dc.date.available2010-09-17T10:15:41Z-
dc.date.issued2003en_HK
dc.identifier.citationChinese Journal of Antibiotics, 2003, v. 28 n. 9, p. 532-533+S2en_HK
dc.identifier.issn1001-8689en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91253-
dc.description.abstractObjective: To develop a method for the determination of peroxide value in sirolimus oral solution. Methods: A potentiometric - iodometry method was conducted. Sirolimus was dissolved in methanol, and excess volume of iodine titrant was added. The titration was carried out using (Chinese characters S2 Chinese characters) (Chinese characters 540 Chinese characters) Mettler DL67 automatic titrator with 0. 01mol/L sodium thiosulphate as blank titrant to reach the endpoint, with Mettler DM140-SC Electrode as potential indicator. In order to acquire the net content of peroxide value in oral solution, a blank determination was performed. Results: The method showed a smooth titration curve, high sensitivity and good reproducibility. Conclusions: The method was convenient and accurate. It provided a suitable method to determine the peroxide value in sirolimus oral solution.en_HK
dc.languageengen_HK
dc.relation.ispartofChinese Journal of Antibioticsen_HK
dc.subjectDeterminationen_HK
dc.subjectIodometryen_HK
dc.subjectPeroxide Valueen_HK
dc.subjectPotentiometryen_HK
dc.titleDetermination of peroxide value in sirolimus oral solution by potentiometric-iodometryen_HK
dc.typeArticleen_HK
dc.identifier.emailCheng, Y:yuecheng@hku.hken_HK
dc.identifier.authorityCheng, Y=rp1320en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0142198378en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0142198378&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue9en_HK
dc.identifier.spage532en_HK
dc.identifier.epage533+S2en_HK

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