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Article: p53 inactivating mutations in Chinese nasopharyngeal carcinomas

Titlep53 inactivating mutations in Chinese nasopharyngeal carcinomas
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1998
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 1998, v. 133 n. 1, p. 89-94 How to Cite?
AbstractPreviously a low frequency of p53 mutations was detected in nasopharyngeal carcinoma (NPC) using molecular techniques to screen for mutations, yet immunohistochemical staining revealed a high frequency of p53 aberrant proteins. These findings might be attributed to the occurrence of p53 mutations outside the common hot spots and/or the inactivation of the protein through interactions with cellular or viral proteins. Using a previously established simple and sensitive p53 yeast functional assay, we blindly screened 25 nasopharyngeal biopsies for p53 mutations from exons 4 to 11. p53 was mutated in 27.3% of NPC specimens and in 0% of the nasopharyngeal biopsies from patients with non-malignant diseases. Two p53 mutations were detected in exon 7 and two were detected in exon 8. Interestingly, the exon 8 mutations observed in NPC lie in codons which appear to be hot spots for mutations in other head and neck cancers. Copyright (C) 1998 Elsevier Science Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/91250
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLung, MLen_HK
dc.contributor.authorHu, Yen_HK
dc.contributor.authorCheng, Yen_HK
dc.contributor.authorLi, MFen_HK
dc.contributor.authorTang, CMCen_HK
dc.contributor.authorO, SKen_HK
dc.contributor.authorIggo, RDen_HK
dc.date.accessioned2010-09-17T10:15:38Z-
dc.date.available2010-09-17T10:15:38Z-
dc.date.issued1998en_HK
dc.identifier.citationCancer Letters, 1998, v. 133 n. 1, p. 89-94en_HK
dc.identifier.issn0304-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91250-
dc.description.abstractPreviously a low frequency of p53 mutations was detected in nasopharyngeal carcinoma (NPC) using molecular techniques to screen for mutations, yet immunohistochemical staining revealed a high frequency of p53 aberrant proteins. These findings might be attributed to the occurrence of p53 mutations outside the common hot spots and/or the inactivation of the protein through interactions with cellular or viral proteins. Using a previously established simple and sensitive p53 yeast functional assay, we blindly screened 25 nasopharyngeal biopsies for p53 mutations from exons 4 to 11. p53 was mutated in 27.3% of NPC specimens and in 0% of the nasopharyngeal biopsies from patients with non-malignant diseases. Two p53 mutations were detected in exon 7 and two were detected in exon 8. Interestingly, the exon 8 mutations observed in NPC lie in codons which appear to be hot spots for mutations in other head and neck cancers. Copyright (C) 1998 Elsevier Science Ireland Ltd.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_HK
dc.relation.ispartofCancer Lettersen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshDNA - chemistryen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenes, p53en_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMutationen_HK
dc.subject.meshNasopharyngeal Neoplasms - geneticsen_HK
dc.titlep53 inactivating mutations in Chinese nasopharyngeal carcinomasen_HK
dc.typeArticleen_HK
dc.identifier.emailLung, ML:mlilung@hku.hken_HK
dc.identifier.emailCheng, Y:yuecheng@hku.hken_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.identifier.authorityCheng, Y=rp01320en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0304-3835(98)00209-2en_HK
dc.identifier.pmid9929165-
dc.identifier.scopuseid_2-s2.0-0032433680en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032433680&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume133en_HK
dc.identifier.issue1en_HK
dc.identifier.spage89en_HK
dc.identifier.epage94en_HK
dc.identifier.isiWOS:000077858500012-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK
dc.identifier.scopusauthoridHu, Y=7407117315en_HK
dc.identifier.scopusauthoridCheng, Y=36131038300en_HK
dc.identifier.scopusauthoridLi, MF=26663915600en_HK
dc.identifier.scopusauthoridTang, CMC=8274797200en_HK
dc.identifier.scopusauthoridO, SK=6603967563en_HK
dc.identifier.scopusauthoridIggo, RD=7004315991en_HK

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