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Article: Alzheimer-type of pathological changes in Chinese

TitleAlzheimer-type of pathological changes in Chinese
Authors
KeywordsReferences (45) View In Table Layout
Issue Date1997
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jns
Citation
Journal of the Neurological Sciences, 1997, v. 145 n. 1, p. 97-103 How to Cite?
AbstractThere has been no previous description of the pathological features of Alzheimer's disease and little description of Alzheimer-type changes in Chinese brains. In this study, we examined the brains of 17 cases of Alzheimer's disease and concurrently 95 consecutive autopsy cases of non-demented patients aged above 60. Six standard regions of the brains were stained for β-amyloid immunostaining, Bielschowsky and Bodian. Neuritic plaques, neurofibrillary tangles and diffuse plaques were quantified as per mm2. The Alzheimer's disease brains exhibited a marked increase of neurodegenerative changes over the non-demented brains. Plaque counts were similar to those proposed by Khachaturian (1985; Arch. Neurol. 42: 1097-1105) and CERAD, although the distribution of tangles was more variable with some regions of the neocortex containing few or no tangles. For the non-demented brains, overall neuritic plaques were seen in 31% and neurofibrillary tangles were seen in 42% of cases, with the overall plaque score being 1.8 per mm2 and tangle score being 0.7 per mm2. No age-dependent variation of plaque count and tangle count could be demonstrated in this group of elderly brains. Comparison with similar studies of Caucasians suggests that neuritic plaques and neurofibrillary tangles were less frequently encountered in aging Chinese brains than among the western populations.
Persistent Identifierhttp://hdl.handle.net/10722/91249
ISSN
2015 Impact Factor: 2.126
2015 SCImago Journal Rankings: 1.024
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, H-Ken_HK
dc.contributor.authorCheng, Yen_HK
dc.contributor.authorPoon, W-Sen_HK
dc.date.accessioned2010-09-17T10:15:37Z-
dc.date.available2010-09-17T10:15:37Z-
dc.date.issued1997en_HK
dc.identifier.citationJournal of the Neurological Sciences, 1997, v. 145 n. 1, p. 97-103en_HK
dc.identifier.issn0022-510Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/91249-
dc.description.abstractThere has been no previous description of the pathological features of Alzheimer's disease and little description of Alzheimer-type changes in Chinese brains. In this study, we examined the brains of 17 cases of Alzheimer's disease and concurrently 95 consecutive autopsy cases of non-demented patients aged above 60. Six standard regions of the brains were stained for β-amyloid immunostaining, Bielschowsky and Bodian. Neuritic plaques, neurofibrillary tangles and diffuse plaques were quantified as per mm2. The Alzheimer's disease brains exhibited a marked increase of neurodegenerative changes over the non-demented brains. Plaque counts were similar to those proposed by Khachaturian (1985; Arch. Neurol. 42: 1097-1105) and CERAD, although the distribution of tangles was more variable with some regions of the neocortex containing few or no tangles. For the non-demented brains, overall neuritic plaques were seen in 31% and neurofibrillary tangles were seen in 42% of cases, with the overall plaque score being 1.8 per mm2 and tangle score being 0.7 per mm2. No age-dependent variation of plaque count and tangle count could be demonstrated in this group of elderly brains. Comparison with similar studies of Caucasians suggests that neuritic plaques and neurofibrillary tangles were less frequently encountered in aging Chinese brains than among the western populations.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jnsen_HK
dc.relation.ispartofJournal of the Neurological Sciencesen_HK
dc.subjectReferences (45) View In Table Layouten_HK
dc.titleAlzheimer-type of pathological changes in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailCheng, Y:yuecheng@hku.hken_HK
dc.identifier.authorityCheng, Y=rp1320en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0022-510X(96)00253-5en_HK
dc.identifier.pmid9073036-
dc.identifier.scopuseid_2-s2.0-0030891976en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030891976&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume145en_HK
dc.identifier.issue1en_HK
dc.identifier.spage97en_HK
dc.identifier.epage103en_HK
dc.identifier.isiWOS:A1997WN13600017-

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