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Article: SON is a spliceosome-associated factor required for mitotic progression

TitleSON is a spliceosome-associated factor required for mitotic progression
Authors
KeywordsMAD2
Mitosis
SON
Splicing factor
Issue Date2010
PublisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/cc
Citation
Cell Cycle, 2010, v. 9 n. 13, p. 2679-2685 How to Cite?
AbstractThe eukaryotic RNA splicing machinery is dedicated to the daunting task of excising intronic sequences on the many nascent RNA transcripts in a cell, and in doing so facilitates proper translation of its transcriptome. Notably, emerging evidence suggests that RNA splicing may also play direct roles in maintaining genome stability. Here we report the identification of the RNA/DNA-binding protein SON as a component of spliceosome that plays pleiotropic roles during mitotic progression. We found that SON is essential for cell proliferation, and that its inactivation triggers a MAD2-dependent mitotic delay. Moreover, SON deficiency is accompanied by defective chromosome congression, compromised chromosome segregation and cytokinesis, which in turn contributes to cellular aneuploidy and cell death. In summary, our study uncovers a specific link between SON and mitosis, and highlights the potential of RNA processing as additional regulatory mechanisms that govern cell proliferation and division. © 2010 Landes Bioscience.
Persistent Identifierhttp://hdl.handle.net/10722/91162
ISSN
2015 Impact Factor: 3.952
2015 SCImago Journal Rankings: 2.244
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of HealthCA113381
Department of DefenceP50 CA116201
200908159008
Funding Information:

This work was supported in part by grants from the National Institutes of Health (CA113381 to J.C.) and Seed Funding for Basic Research (Project Code: 200908159008; HKU to M.S.Y.H.). M.S.Y.H. would like to thank Drs. Chris Klug and Jim Mulloy for valuable reagents, Drs. Zhiwei Chen and Henggui Liu for help with flow cytometry analysis, Mr. Tony Chan, Prof. George Tsao and the Faculty Core Imaging Facility for technical support with time-lapse microscopy, and is grateful to J.C. for his continuous support. J.C. is a recipient of an Era of Hope Scholar award from the Department of Defence and a member of the Mayo Clinic Breast SPORE program (P50 CA116201).

References

 

DC FieldValueLanguage
dc.contributor.authorHuen, MSYen_HK
dc.contributor.authorSy, SMHen_HK
dc.contributor.authorLeung, KMen_HK
dc.contributor.authorChing, YPen_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorMan, Cen_HK
dc.contributor.authorDong, Sen_HK
dc.contributor.authorChen, Jen_HK
dc.date.accessioned2010-09-17T10:13:58Z-
dc.date.available2010-09-17T10:13:58Z-
dc.date.issued2010en_HK
dc.identifier.citationCell Cycle, 2010, v. 9 n. 13, p. 2679-2685en_HK
dc.identifier.issn1538-4101en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91162-
dc.description.abstractThe eukaryotic RNA splicing machinery is dedicated to the daunting task of excising intronic sequences on the many nascent RNA transcripts in a cell, and in doing so facilitates proper translation of its transcriptome. Notably, emerging evidence suggests that RNA splicing may also play direct roles in maintaining genome stability. Here we report the identification of the RNA/DNA-binding protein SON as a component of spliceosome that plays pleiotropic roles during mitotic progression. We found that SON is essential for cell proliferation, and that its inactivation triggers a MAD2-dependent mitotic delay. Moreover, SON deficiency is accompanied by defective chromosome congression, compromised chromosome segregation and cytokinesis, which in turn contributes to cellular aneuploidy and cell death. In summary, our study uncovers a specific link between SON and mitosis, and highlights the potential of RNA processing as additional regulatory mechanisms that govern cell proliferation and division. © 2010 Landes Bioscience.en_HK
dc.languageengen_HK
dc.publisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/ccen_HK
dc.relation.ispartofCell Cycleen_HK
dc.subjectMAD2en_HK
dc.subjectMitosisen_HK
dc.subjectSONen_HK
dc.subjectSplicing factoren_HK
dc.titleSON is a spliceosome-associated factor required for mitotic progressionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1538-4101&volume=9&issue=13&spage=2679&epage=2685&date=2010&atitle=SON+is+a+spliceosome-associated+factor+required+for+mitotic+progression-
dc.identifier.emailHuen, MSY:huen.michael@hku.hken_HK
dc.identifier.emailChing, YP:ypching@hku.hken_HK
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_HK
dc.identifier.authorityHuen, MSY=rp01336en_HK
dc.identifier.authorityChing, YP=rp00469en_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.4161/cc.9.13.12151en_HK
dc.identifier.pmid20581448-
dc.identifier.pmcidPMC3040851-
dc.identifier.scopuseid_2-s2.0-77955437789en_HK
dc.identifier.hkuros172616-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955437789&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue13en_HK
dc.identifier.spage2679en_HK
dc.identifier.epage2685en_HK
dc.identifier.isiWOS:000281205400043-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHuen, MSY=23004751500en_HK
dc.identifier.scopusauthoridSy, SMH=6602984466en_HK
dc.identifier.scopusauthoridLeung, KM=7401860685en_HK
dc.identifier.scopusauthoridChing, YP=7005431277en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridMan, C=7005722377en_HK
dc.identifier.scopusauthoridDong, S=7402016497en_HK
dc.identifier.scopusauthoridChen, J=35261693300en_HK

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