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Article: Sequence variations in the transcriptional regulatory region and intron1 of HLA-DQB1 gene and their linkage in southern Chinese ethnic groups

TitleSequence variations in the transcriptional regulatory region and intron1 of HLA-DQB1 gene and their linkage in southern Chinese ethnic groups
Authors
KeywordsMolecular Sequence Numbers
Issue Date2005
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00251/index.htm
Citation
Immunogenetics, 2005, v. 57 n. 7, p. 465-478 How to Cite?
AbstractSequence polymorphism in the transcriptional regulatory region extending to intron1 (DQRRI1) of HLA-DQB1 gene, and their haplotypic distributions were investigated in southern Chinese populations. We cloned and sequenced a 1.1-kb segment containing the transcriptional regulatory region, exon1, and partial intron1 of HLA-DQB1 gene of 37 individuals from nine different ethnic groups in southern China. A high-density map of 162 polymorphisms, including 152 single nucleotide polymorphisms (SNPs) and 10 insertion-deletion polymorphisms, was revealed. By comparing these data with SNPs deposited in dbSNP database in National Center for Biotechnology Information and polymorphisms that have been reported, 66 polymorphisms were firstly reported. A total of 16 different haplotypes were detected based on these 162 polymorphisms. The distribution of 16 alleles of DQRRI1 as well as their linkage with DQB1 exon2 alleles was also investigated based on the population study and phylogenetic analysis. Tight linkage between these two regions were discovered, as each of DQB1*02, DQB1*03, DQB1*04, DQB1*05, and DQB1*06 alleles was seen to be linked with specific DQRRI1 allele. Our study showed different pattern of transcriptional regulatory region, exon1, and intron1 of different DQB1 alleles. © Springer-Verlag 2005.
Persistent Identifierhttp://hdl.handle.net/10722/91123
ISSN
2015 Impact Factor: 2.303
2015 SCImago Journal Rankings: 1.557
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, Yen_HK
dc.contributor.authorHu, Qen_HK
dc.contributor.authorLiu, Zen_HK
dc.contributor.authorShen, Yen_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorLin, Ben_HK
dc.contributor.authorWu, Yen_HK
dc.contributor.authorChen, Sen_HK
dc.contributor.authorXu, Aen_HK
dc.date.accessioned2010-09-17T10:13:22Z-
dc.date.available2010-09-17T10:13:22Z-
dc.date.issued2005en_HK
dc.identifier.citationImmunogenetics, 2005, v. 57 n. 7, p. 465-478en_HK
dc.identifier.issn0093-7711en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91123-
dc.description.abstractSequence polymorphism in the transcriptional regulatory region extending to intron1 (DQRRI1) of HLA-DQB1 gene, and their haplotypic distributions were investigated in southern Chinese populations. We cloned and sequenced a 1.1-kb segment containing the transcriptional regulatory region, exon1, and partial intron1 of HLA-DQB1 gene of 37 individuals from nine different ethnic groups in southern China. A high-density map of 162 polymorphisms, including 152 single nucleotide polymorphisms (SNPs) and 10 insertion-deletion polymorphisms, was revealed. By comparing these data with SNPs deposited in dbSNP database in National Center for Biotechnology Information and polymorphisms that have been reported, 66 polymorphisms were firstly reported. A total of 16 different haplotypes were detected based on these 162 polymorphisms. The distribution of 16 alleles of DQRRI1 as well as their linkage with DQB1 exon2 alleles was also investigated based on the population study and phylogenetic analysis. Tight linkage between these two regions were discovered, as each of DQB1*02, DQB1*03, DQB1*04, DQB1*05, and DQB1*06 alleles was seen to be linked with specific DQRRI1 allele. Our study showed different pattern of transcriptional regulatory region, exon1, and intron1 of different DQB1 alleles. © Springer-Verlag 2005.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00251/index.htmen_HK
dc.relation.ispartofImmunogeneticsen_HK
dc.subjectMolecular Sequence Numbersen_HK
dc.titleSequence variations in the transcriptional regulatory region and intron1 of HLA-DQB1 gene and their linkage in southern Chinese ethnic groupsen_HK
dc.typeArticleen_HK
dc.identifier.emailLin, B:blin@hku.hken_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00251-005-0017-xen_HK
dc.identifier.pmid16078082-
dc.identifier.scopuseid_2-s2.0-25844523834en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-25844523834&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume57en_HK
dc.identifier.issue7en_HK
dc.identifier.spage465en_HK
dc.identifier.epage478en_HK
dc.identifier.isiWOS:000232340200001-

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