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Article: Distribution of glycine receptor subunits on primate retinal ganglion cells: A quantitative analysis

TitleDistribution of glycine receptor subunits on primate retinal ganglion cells: A quantitative analysis
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2000
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJN
Citation
European Journal Of Neuroscience, 2000, v. 12 n. 12, p. 4155-4170 How to Cite?
AbstractThis study investigates the distribution of inhibitory neurotransmitter receptors on sensory neurons. Ganglion cells in the retina of a New World monkey, the common marmoset Callithrix jacchus, were injected with Lucifer yellow and Neurobiotin and subsequently processed with antibodies against one (α1), or against all subunits, of the glycine receptor, or against the anchoring protein gephyrin. Immunoreactive (IR) puncta representing glycine receptor or gephyrin clusters were found on the proximal and the distal dendrites of all ganglion cell types investigated. For both parasol and midget cells, the density of receptor clusters was greater on distal than proximal dendrites for all antibodies tested. In parasol cells the average density for the α1 subunit of the glycine receptor was 0.087 IR puncta/μm of dendrite, and for all subunits it was 0.119 IR puncta/μm of dendrite. Thus, the majority of glycine receptors on parasol cells contain the α1 subunit. For parasol cells, we estimated an average of 1.5 glycinergic synapses/100 μm2 dendritic membrane on proximal dendrites and about 9.4 glycinergic synapses/100 μm2 on distal dendrites. The segregation of receptors to the distal dendrites appears to be a common feature of inhibitory neurotransmitter input to parasol and midget cells, and might be associated with the receptive field surround mechanism.
Persistent Identifierhttp://hdl.handle.net/10722/91087
ISSN
2015 Impact Factor: 2.975
2015 SCImago Journal Rankings: 2.130
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, Ben_HK
dc.contributor.authorMartin, PRen_HK
dc.contributor.authorSolomon, SGen_HK
dc.contributor.authorGrünert, Uen_HK
dc.date.accessioned2010-09-17T10:12:50Z-
dc.date.available2010-09-17T10:12:50Z-
dc.date.issued2000en_HK
dc.identifier.citationEuropean Journal Of Neuroscience, 2000, v. 12 n. 12, p. 4155-4170en_HK
dc.identifier.issn0953-816Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/91087-
dc.description.abstractThis study investigates the distribution of inhibitory neurotransmitter receptors on sensory neurons. Ganglion cells in the retina of a New World monkey, the common marmoset Callithrix jacchus, were injected with Lucifer yellow and Neurobiotin and subsequently processed with antibodies against one (α1), or against all subunits, of the glycine receptor, or against the anchoring protein gephyrin. Immunoreactive (IR) puncta representing glycine receptor or gephyrin clusters were found on the proximal and the distal dendrites of all ganglion cell types investigated. For both parasol and midget cells, the density of receptor clusters was greater on distal than proximal dendrites for all antibodies tested. In parasol cells the average density for the α1 subunit of the glycine receptor was 0.087 IR puncta/μm of dendrite, and for all subunits it was 0.119 IR puncta/μm of dendrite. Thus, the majority of glycine receptors on parasol cells contain the α1 subunit. For parasol cells, we estimated an average of 1.5 glycinergic synapses/100 μm2 dendritic membrane on proximal dendrites and about 9.4 glycinergic synapses/100 μm2 on distal dendrites. The segregation of receptors to the distal dendrites appears to be a common feature of inhibitory neurotransmitter input to parasol and midget cells, and might be associated with the receptive field surround mechanism.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJNen_HK
dc.relation.ispartofEuropean Journal of Neuroscienceen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntibodies, Monoclonalen_HK
dc.subject.meshBiotin - analogs & derivativesen_HK
dc.subject.meshCallithrixen_HK
dc.subject.meshCarrier Proteins - analysisen_HK
dc.subject.meshDendrites - ultrastructureen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshIsoquinolinesen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMembrane Proteins - analysisen_HK
dc.subject.meshProtein Subunitsen_HK
dc.subject.meshReceptors, Glycine - analysisen_HK
dc.subject.meshRetinal Ganglion Cells - cytologyen_HK
dc.titleDistribution of glycine receptor subunits on primate retinal ganglion cells: A quantitative analysisen_HK
dc.typeArticleen_HK
dc.identifier.emailLin, B:blin@hku.hken_HK
dc.identifier.authorityLin, B=rp01356en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1460-9568.2000.01311.xen_HK
dc.identifier.pmid11122328-
dc.identifier.scopuseid_2-s2.0-0034502512en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034502512&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue12en_HK
dc.identifier.spage4155en_HK
dc.identifier.epage4170en_HK
dc.identifier.isiWOS:000166113000001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLin, B=36165916900en_HK
dc.identifier.scopusauthoridMartin, PR=7406040488en_HK
dc.identifier.scopusauthoridSolomon, SG=7401460528en_HK
dc.identifier.scopusauthoridGrünert, U=7004613233en_HK

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