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Article: Acute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: Striking similarities and obvious differences with mammals

TitleAcute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: Striking similarities and obvious differences with mammals
Authors
KeywordsSpecies Index: Aeromonas Salmonicida
Danio Rerio
Mammalia
Negibacteria
Posibacteria
Staphylococcus Aureus
Issue Date2007
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/molimm
Citation
Molecular Immunology, 2007, v. 44 n. 4, p. 295-301 How to Cite?
AbstractZebrafish has emerged as a valuable model for immunological studies. However, little is known about the overall picture of its immune response to infectious pathogens. Here we present the first systematic study of its immune response to Aeromonas salmonicida and Staphylococcus aureus, a Gram-negative and a Gram-positive bacteria, respectively. Genes induced upon infection were identified with suppression subtractive hybridization, with many of them encoding acute phase proteins (APPs). When compared with mammals, striking similarities and obvious differences have been observed. Both similar APPs (SAA, hepcidin and haptoglobin, etc.) and a similar system for the induction of APPs (which involves the TLRs, pro-inflammatory cytokines and C/EBPs) were identified, implying evolutionary conserved mechanisms among fish and mammals. Some novel APPs were also discovered, suggesting different immune strategies adopted by fish species. Among which, LECT2 was induced by up to 1000-fold upon infection, shedding new lights on the function of this gene. Our results constitute the first demonstration of a similar while different immune response in zebrafish and open new avenues for the investigation of evolutionary conserved and fish specific mechanisms of innate immunity. © 2006 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/91077
ISSN
2014 Impact Factor: 2.973
2014 SCImago Journal Rankings: 1.235
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, Ben_HK
dc.contributor.authorChen, Sen_HK
dc.contributor.authorCao, Zen_HK
dc.contributor.authorLin, Yen_HK
dc.contributor.authorMo, Den_HK
dc.contributor.authorZhang, Hen_HK
dc.contributor.authorGu, Jen_HK
dc.contributor.authorDong, Men_HK
dc.contributor.authorLiu, Zen_HK
dc.contributor.authorXu, Aen_HK
dc.date.accessioned2010-09-17T10:12:41Z-
dc.date.available2010-09-17T10:12:41Z-
dc.date.issued2007en_HK
dc.identifier.citationMolecular Immunology, 2007, v. 44 n. 4, p. 295-301en_HK
dc.identifier.issn0161-5890en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91077-
dc.description.abstractZebrafish has emerged as a valuable model for immunological studies. However, little is known about the overall picture of its immune response to infectious pathogens. Here we present the first systematic study of its immune response to Aeromonas salmonicida and Staphylococcus aureus, a Gram-negative and a Gram-positive bacteria, respectively. Genes induced upon infection were identified with suppression subtractive hybridization, with many of them encoding acute phase proteins (APPs). When compared with mammals, striking similarities and obvious differences have been observed. Both similar APPs (SAA, hepcidin and haptoglobin, etc.) and a similar system for the induction of APPs (which involves the TLRs, pro-inflammatory cytokines and C/EBPs) were identified, implying evolutionary conserved mechanisms among fish and mammals. Some novel APPs were also discovered, suggesting different immune strategies adopted by fish species. Among which, LECT2 was induced by up to 1000-fold upon infection, shedding new lights on the function of this gene. Our results constitute the first demonstration of a similar while different immune response in zebrafish and open new avenues for the investigation of evolutionary conserved and fish specific mechanisms of innate immunity. © 2006 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/molimmen_HK
dc.relation.ispartofMolecular Immunologyen_HK
dc.subjectSpecies Index: Aeromonas Salmonicidaen_HK
dc.subjectDanio Rerioen_HK
dc.subjectMammaliaen_HK
dc.subjectNegibacteriaen_HK
dc.subjectPosibacteriaen_HK
dc.subjectStaphylococcus Aureusen_HK
dc.titleAcute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: Striking similarities and obvious differences with mammalsen_HK
dc.typeArticleen_HK
dc.identifier.emailLin, B:blin@hku.hken_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.molimm.2006.03.001en_HK
dc.identifier.pmid16630661-
dc.identifier.scopuseid_2-s2.0-33748193069en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748193069&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue4en_HK
dc.identifier.spage295en_HK
dc.identifier.epage301en_HK
dc.identifier.isiWOS:000241460900004-

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