Article: Acute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: Striking similarities and obvious differences with mammals

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TitleAcute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: Striking similarities and obvious differences with mammals
AuthorsLin, B1
Chen, S1
Cao, Z1
Lin, Y1
Mo, D1
Zhang, H1
Gu, J1
Dong, M1
Liu, Z1
Xu, A1
KeywordsSpecies Index: Aeromonas Salmonicida
Danio Rerio
Mammalia
Negibacteria
Posibacteria
Staphylococcus Aureus
Issue Date2007
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/molimm
CitationMolecular Immunology, 2007, v. 44 n. 4, p. 295-301 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.molimm.2006.03.001
AbstractZebrafish has emerged as a valuable model for immunological studies. However, little is known about the overall picture of its immune response to infectious pathogens. Here we present the first systematic study of its immune response to Aeromonas salmonicida and Staphylococcus aureus, a Gram-negative and a Gram-positive bacteria, respectively. Genes induced upon infection were identified with suppression subtractive hybridization, with many of them encoding acute phase proteins (APPs). When compared with mammals, striking similarities and obvious differences have been observed. Both similar APPs (SAA, hepcidin and haptoglobin, etc.) and a similar system for the induction of APPs (which involves the TLRs, pro-inflammatory cytokines and C/EBPs) were identified, implying evolutionary conserved mechanisms among fish and mammals. Some novel APPs were also discovered, suggesting different immune strategies adopted by fish species. Among which, LECT2 was induced by up to 1000-fold upon infection, shedding new lights on the function of this gene. Our results constitute the first demonstration of a similar while different immune response in zebrafish and open new avenues for the investigation of evolutionary conserved and fish specific mechanisms of innate immunity. © 2006 Elsevier Ltd. All rights reserved.
ISSN0161-5890
2011 Impact Factor: 2.897
2011 SCImago Journal Rankings: 0.401
DOIhttp://dx.doi.org/10.1016/j.molimm.2006.03.001
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLin, B
dc.contributor.authorChen, S
dc.contributor.authorCao, Z
dc.contributor.authorLin, Y
dc.contributor.authorMo, D
dc.contributor.authorZhang, H
dc.contributor.authorGu, J
dc.contributor.authorDong, M
dc.contributor.authorLiu, Z
dc.contributor.authorXu, A
dc.date.accessioned2010-09-17T10:12:41Z
dc.date.available2010-09-17T10:12:41Z
dc.date.issued2007
dc.description.abstractZebrafish has emerged as a valuable model for immunological studies. However, little is known about the overall picture of its immune response to infectious pathogens. Here we present the first systematic study of its immune response to Aeromonas salmonicida and Staphylococcus aureus, a Gram-negative and a Gram-positive bacteria, respectively. Genes induced upon infection were identified with suppression subtractive hybridization, with many of them encoding acute phase proteins (APPs). When compared with mammals, striking similarities and obvious differences have been observed. Both similar APPs (SAA, hepcidin and haptoglobin, etc.) and a similar system for the induction of APPs (which involves the TLRs, pro-inflammatory cytokines and C/EBPs) were identified, implying evolutionary conserved mechanisms among fish and mammals. Some novel APPs were also discovered, suggesting different immune strategies adopted by fish species. Among which, LECT2 was induced by up to 1000-fold upon infection, shedding new lights on the function of this gene. Our results constitute the first demonstration of a similar while different immune response in zebrafish and open new avenues for the investigation of evolutionary conserved and fish specific mechanisms of innate immunity. © 2006 Elsevier Ltd. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationMolecular Immunology, 2007, v. 44 n. 4, p. 295-301 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.molimm.2006.03.001
dc.identifier.doihttp://dx.doi.org/10.1016/j.molimm.2006.03.001
dc.identifier.epage301
dc.identifier.isiWOS:000241460900004
dc.identifier.issn0161-5890
2011 Impact Factor: 2.897
2011 SCImago Journal Rankings: 0.401
dc.identifier.issue4
dc.identifier.pmid16630661
dc.identifier.scopuseid_2-s2.0-33748193069
dc.identifier.spage295
dc.identifier.urihttp://hdl.handle.net/10722/91077
dc.identifier.volume44
dc.languageeng
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/molimm
dc.relation.ispartofMolecular Immunology
dc.relation.referencesReferences in Scopus
dc.subjectSpecies Index: Aeromonas Salmonicida
dc.subjectDanio Rerio
dc.subjectMammalia
dc.subjectNegibacteria
dc.subjectPosibacteria
dc.subjectStaphylococcus Aureus
dc.titleAcute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: Striking similarities and obvious differences with mammals
dc.typeArticle
Author Affiliations
  1. The Open Laboratory for Marine Functional Genomics of State High-Tech Development Program