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Article: Acute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: Striking similarities and obvious differences with mammals
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TitleAcute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: Striking similarities and obvious differences with mammals
 
AuthorsLin, B1
Chen, S1
Cao, Z1
Lin, Y1
Mo, D1
Zhang, H1
Gu, J1
Dong, M1
Liu, Z1
Xu, A1
 
KeywordsSpecies Index: Aeromonas Salmonicida
Danio Rerio
Mammalia
Negibacteria
Posibacteria
Staphylococcus Aureus
 
Issue Date2007
 
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/molimm
 
CitationMolecular Immunology, 2007, v. 44 n. 4, p. 295-301 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.molimm.2006.03.001
 
AbstractZebrafish has emerged as a valuable model for immunological studies. However, little is known about the overall picture of its immune response to infectious pathogens. Here we present the first systematic study of its immune response to Aeromonas salmonicida and Staphylococcus aureus, a Gram-negative and a Gram-positive bacteria, respectively. Genes induced upon infection were identified with suppression subtractive hybridization, with many of them encoding acute phase proteins (APPs). When compared with mammals, striking similarities and obvious differences have been observed. Both similar APPs (SAA, hepcidin and haptoglobin, etc.) and a similar system for the induction of APPs (which involves the TLRs, pro-inflammatory cytokines and C/EBPs) were identified, implying evolutionary conserved mechanisms among fish and mammals. Some novel APPs were also discovered, suggesting different immune strategies adopted by fish species. Among which, LECT2 was induced by up to 1000-fold upon infection, shedding new lights on the function of this gene. Our results constitute the first demonstration of a similar while different immune response in zebrafish and open new avenues for the investigation of evolutionary conserved and fish specific mechanisms of innate immunity. © 2006 Elsevier Ltd. All rights reserved.
 
ISSN0161-5890
2013 Impact Factor: 3.003
2013 SCImago Journal Rankings: 1.474
 
DOIhttp://dx.doi.org/10.1016/j.molimm.2006.03.001
 
ISI Accession Number IDWOS:000241460900004
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLin, B
 
dc.contributor.authorChen, S
 
dc.contributor.authorCao, Z
 
dc.contributor.authorLin, Y
 
dc.contributor.authorMo, D
 
dc.contributor.authorZhang, H
 
dc.contributor.authorGu, J
 
dc.contributor.authorDong, M
 
dc.contributor.authorLiu, Z
 
dc.contributor.authorXu, A
 
dc.date.accessioned2010-09-17T10:12:41Z
 
dc.date.available2010-09-17T10:12:41Z
 
dc.date.issued2007
 
dc.description.abstractZebrafish has emerged as a valuable model for immunological studies. However, little is known about the overall picture of its immune response to infectious pathogens. Here we present the first systematic study of its immune response to Aeromonas salmonicida and Staphylococcus aureus, a Gram-negative and a Gram-positive bacteria, respectively. Genes induced upon infection were identified with suppression subtractive hybridization, with many of them encoding acute phase proteins (APPs). When compared with mammals, striking similarities and obvious differences have been observed. Both similar APPs (SAA, hepcidin and haptoglobin, etc.) and a similar system for the induction of APPs (which involves the TLRs, pro-inflammatory cytokines and C/EBPs) were identified, implying evolutionary conserved mechanisms among fish and mammals. Some novel APPs were also discovered, suggesting different immune strategies adopted by fish species. Among which, LECT2 was induced by up to 1000-fold upon infection, shedding new lights on the function of this gene. Our results constitute the first demonstration of a similar while different immune response in zebrafish and open new avenues for the investigation of evolutionary conserved and fish specific mechanisms of innate immunity. © 2006 Elsevier Ltd. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationMolecular Immunology, 2007, v. 44 n. 4, p. 295-301 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.molimm.2006.03.001
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.molimm.2006.03.001
 
dc.identifier.epage301
 
dc.identifier.isiWOS:000241460900004
 
dc.identifier.issn0161-5890
2013 Impact Factor: 3.003
2013 SCImago Journal Rankings: 1.474
 
dc.identifier.issue4
 
dc.identifier.pmid16630661
 
dc.identifier.scopuseid_2-s2.0-33748193069
 
dc.identifier.spage295
 
dc.identifier.urihttp://hdl.handle.net/10722/91077
 
dc.identifier.volume44
 
dc.languageeng
 
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/molimm
 
dc.relation.ispartofMolecular Immunology
 
dc.relation.referencesReferences in Scopus
 
dc.subjectSpecies Index: Aeromonas Salmonicida
 
dc.subjectDanio Rerio
 
dc.subjectMammalia
 
dc.subjectNegibacteria
 
dc.subjectPosibacteria
 
dc.subjectStaphylococcus Aureus
 
dc.titleAcute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: Striking similarities and obvious differences with mammals
 
dc.typeArticle
 
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<contributor.author>Zhang, H</contributor.author>
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Author Affiliations
  1. The Open Laboratory for Marine Functional Genomics of State High-Tech Development Program