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Article: The DNA damage response pathways: At the crossroad of protein modifications

TitleThe DNA damage response pathways: At the crossroad of protein modifications
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2008
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/cr/marketing/index.html
Citation
Cell Research, 2008, v. 18 n. 1, p. 8-16 How to Cite?
AbstractPost-translational modifications play a crucial role in coordinating cellular response to DNA damage. Recent evidence suggests an interplay between multiple protein modifications, including phosphorylation, ubiquitylation, acetylation and sumoylation, that combine to propagate the DNA damage signal to elicit cell cycle arrest, DNA repair, apoptosis and senescence. Utility of specific post-translational modifiers allows temporal and spatial control over protein relocalization and interactions, and may represent a means for trans-regulatory activation of protein activities. The ability to recognize these specific modifiers also underscores the capacity for signal amplification, a crucial step for the maintenance of genomic stability and tumor prevention. Here we have summarized recent findings that highlight the complexity of post-translational modifications in coordinating the DNA damage response, with emphasis on the DNA damage signaling cascade. © 2008 IBCB, SIBS, CAS. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/91070
ISSN
2015 Impact Factor: 14.812
2015 SCImago Journal Rankings: 4.805
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuen, MSYen_HK
dc.contributor.authorChen, Jen_HK
dc.date.accessioned2010-09-17T10:12:35Z-
dc.date.available2010-09-17T10:12:35Z-
dc.date.issued2008en_HK
dc.identifier.citationCell Research, 2008, v. 18 n. 1, p. 8-16en_HK
dc.identifier.issn1001-0602en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91070-
dc.description.abstractPost-translational modifications play a crucial role in coordinating cellular response to DNA damage. Recent evidence suggests an interplay between multiple protein modifications, including phosphorylation, ubiquitylation, acetylation and sumoylation, that combine to propagate the DNA damage signal to elicit cell cycle arrest, DNA repair, apoptosis and senescence. Utility of specific post-translational modifiers allows temporal and spatial control over protein relocalization and interactions, and may represent a means for trans-regulatory activation of protein activities. The ability to recognize these specific modifiers also underscores the capacity for signal amplification, a crucial step for the maintenance of genomic stability and tumor prevention. Here we have summarized recent findings that highlight the complexity of post-translational modifications in coordinating the DNA damage response, with emphasis on the DNA damage signaling cascade. © 2008 IBCB, SIBS, CAS. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/cr/marketing/index.htmlen_HK
dc.relation.ispartofCell Researchen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshDNA Damage - physiologyen_HK
dc.subject.meshDNA Repair - physiologyen_HK
dc.subject.meshDNA Repair Enzymes - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshPeptide Hydrolases - physiologyen_HK
dc.subject.meshPhosphorylationen_HK
dc.subject.meshProtein Binding - physiologyen_HK
dc.subject.meshProtein Processing, Post-Translational - physiologyen_HK
dc.subject.meshSignal Transduction - physiologyen_HK
dc.subject.meshUbiquitin - metabolismen_HK
dc.subject.meshUbiquitination - genetics - physiologyen_HK
dc.titleThe DNA damage response pathways: At the crossroad of protein modificationsen_HK
dc.typeArticleen_HK
dc.identifier.emailHuen, MSY:huen.michael@hku.hken_HK
dc.identifier.authorityHuen, MSY=rp01336en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/cr.2007.109en_HK
dc.identifier.pmid18087291-
dc.identifier.scopuseid_2-s2.0-38049150586en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38049150586&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue1en_HK
dc.identifier.spage8en_HK
dc.identifier.epage16en_HK
dc.identifier.eissn1748-7838-
dc.identifier.isiWOS:000252920000003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHuen, MSY=23004751500en_HK
dc.identifier.scopusauthoridChen, J=35261693300en_HK
dc.identifier.citeulike2353470-

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