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Article: HLA class II polymorphisms associated with the physiologic characteristics defined by traditional Chinese medicine: Linking modern genetics with an ancient medicine

TitleHLA class II polymorphisms associated with the physiologic characteristics defined by traditional Chinese medicine: Linking modern genetics with an ancient medicine
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2007
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/acm
Citation
Journal of Alternative and Complementary Medicine, 2007, v. 13 n. 2, p. 231-239 How to Cite?
AbstractObjectives: The aim of this study was to test whether human leukocyte antigen (HLA) polymorphism contributes to the physical constitutions classified in Traditional Chinese Medicine (TCM). Design: Seven hundred six (706) individuals of the Han ethnic group inhabiting South China were classified into 7 TCM constitution groups, according to the criteria described in Theories of Physical Constitutions of Traditional Chinese Medicine, and the distributions of HLA-DRB1, DPB1, and DQB1 were investigated using the polymerase chain reaction-sequencing-based typing method. Results: The allele frequencies of DPB1*0501 in the Yin-deficiency group, DRB1*09012 in the Phlegm-wetness group, and DQB1*03032 in the Qi-deficiency and Phlegm-wetness groups were significantly different from that of the corresponding alleles in the Normality constitution, suggesting those alleles might be group-specific alleles and thus related to a particular constitution. Based on our analysis of serological groups of HLA, the associations of DR*04 with the Blood-stasis group and DQ*09 with the Qi-deficiency and Phlegm-wetness groups were observed. Conclusions: This was the first study to systematically investigate the relationship between HLA and TCM constitution using a high-resolution typing technique. The results suggested a genetic basis for the classification of physical constitution in TCM. This study laid the foundation, for the first time ever, toward gaining insight into the theory of traditional medicine using modern biological approaches. © Mary Ann Liebert, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/91026
ISSN
2015 Impact Factor: 1.395
2015 SCImago Journal Rankings: 0.475
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Sen_HK
dc.contributor.authorLv, Fen_HK
dc.contributor.authorGao, Jen_HK
dc.contributor.authorLin, Jen_HK
dc.contributor.authorLiu, Zen_HK
dc.contributor.authorFu, Yen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorLin, Ben_HK
dc.contributor.authorXie, Yen_HK
dc.contributor.authorRen, Xen_HK
dc.contributor.authorXu, Yen_HK
dc.contributor.authorFan, Xen_HK
dc.contributor.authorXu, Aen_HK
dc.date.accessioned2010-09-17T10:11:56Z-
dc.date.available2010-09-17T10:11:56Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal of Alternative and Complementary Medicine, 2007, v. 13 n. 2, p. 231-239en_HK
dc.identifier.issn1075-5535en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91026-
dc.description.abstractObjectives: The aim of this study was to test whether human leukocyte antigen (HLA) polymorphism contributes to the physical constitutions classified in Traditional Chinese Medicine (TCM). Design: Seven hundred six (706) individuals of the Han ethnic group inhabiting South China were classified into 7 TCM constitution groups, according to the criteria described in Theories of Physical Constitutions of Traditional Chinese Medicine, and the distributions of HLA-DRB1, DPB1, and DQB1 were investigated using the polymerase chain reaction-sequencing-based typing method. Results: The allele frequencies of DPB1*0501 in the Yin-deficiency group, DRB1*09012 in the Phlegm-wetness group, and DQB1*03032 in the Qi-deficiency and Phlegm-wetness groups were significantly different from that of the corresponding alleles in the Normality constitution, suggesting those alleles might be group-specific alleles and thus related to a particular constitution. Based on our analysis of serological groups of HLA, the associations of DR*04 with the Blood-stasis group and DQ*09 with the Qi-deficiency and Phlegm-wetness groups were observed. Conclusions: This was the first study to systematically investigate the relationship between HLA and TCM constitution using a high-resolution typing technique. The results suggested a genetic basis for the classification of physical constitution in TCM. This study laid the foundation, for the first time ever, toward gaining insight into the theory of traditional medicine using modern biological approaches. © Mary Ann Liebert, Inc.en_HK
dc.languageengen_HK
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/acmen_HK
dc.relation.ispartofJournal of Alternative and Complementary Medicineen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleHLA class II polymorphisms associated with the physiologic characteristics defined by traditional Chinese medicine: Linking modern genetics with an ancient medicineen_HK
dc.typeArticleen_HK
dc.identifier.emailLin, B:blin@hku.hken_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1089/acm.2006.6126en_HK
dc.identifier.pmid17388766-
dc.identifier.scopuseid_2-s2.0-34047181109en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34047181109&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue2en_HK
dc.identifier.spage231en_HK
dc.identifier.epage239en_HK
dc.identifier.isiWOS:000245292400011-

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