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Article: IFN-producing killer dendritic cells are antigen-presenting cells endowed with T-cell cross-priming capacity

TitleIFN-producing killer dendritic cells are antigen-presenting cells endowed with T-cell cross-priming capacity
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2009, v. 69 n. 16, p. 6607-6614 How to Cite?
AbstractIFN-producing killer dendritic cells (IKDC) represent a recently discovered cell type in the immune system that possesses a number of functions contributing to innate and adaptive immunity, including production of type 1and 2 IFNs, interleukin (IL)-12, natural killing, and ultimately antigen presentation to naïve T cells. Here, we compared in vitro and in vivo responses of mouse IKDC, conventional dendritic cells (DC), and natural killer (NK) cells to murine cytomegalovirus infection and found distinct functions among these cell subsets. Upon recognition of infected fibroblasts, IKDC, as well as NK, produced high level of IFN-γ, but unlike NK, IKDC simultaneously produced IL-12p40 and up-regulated MHC class II (MHC-II) and costimulatory molecules. Using MHC-II molecule expression as a phenotypic marker to distinguish activated IKDC from activated NK, we further showed that highly purified MHC-II+ IKDC but not NK cross-present MHC class I-restricted antigens derived from MCMV-infected targets to CD8+ T cells in vitro and in vivo. Our findings emphasize the unique nature of IKDC as a killer antigen-presenting cell directly linking innate and adaptive immunity. ©2009 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/91019
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
NIH5U19CA113 341
Janey Fund and Seraph Foundation
Bill and Betty Topece and Dorothy Needle
Funding Information:

NIH grant (5U19CA113 341), the Janey Fund and Seraph Foundation, and gifts from Bill and Betty Topece and Dorothy Needle.

References

 

DC FieldValueLanguage
dc.contributor.authorPletneva, Men_HK
dc.contributor.authorFan, Hen_HK
dc.contributor.authorPark, JJen_HK
dc.contributor.authorRadojcic, Ven_HK
dc.contributor.authorJie, Cen_HK
dc.contributor.authorYu, Yen_HK
dc.contributor.authorChan, Cen_HK
dc.contributor.authorRedwood, Aen_HK
dc.contributor.authorPardoll, Den_HK
dc.contributor.authorHousseau, Fen_HK
dc.date.accessioned2010-09-17T10:11:50Z-
dc.date.available2010-09-17T10:11:50Z-
dc.date.issued2009en_HK
dc.identifier.citationCancer Research, 2009, v. 69 n. 16, p. 6607-6614en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91019-
dc.description.abstractIFN-producing killer dendritic cells (IKDC) represent a recently discovered cell type in the immune system that possesses a number of functions contributing to innate and adaptive immunity, including production of type 1and 2 IFNs, interleukin (IL)-12, natural killing, and ultimately antigen presentation to naïve T cells. Here, we compared in vitro and in vivo responses of mouse IKDC, conventional dendritic cells (DC), and natural killer (NK) cells to murine cytomegalovirus infection and found distinct functions among these cell subsets. Upon recognition of infected fibroblasts, IKDC, as well as NK, produced high level of IFN-γ, but unlike NK, IKDC simultaneously produced IL-12p40 and up-regulated MHC class II (MHC-II) and costimulatory molecules. Using MHC-II molecule expression as a phenotypic marker to distinguish activated IKDC from activated NK, we further showed that highly purified MHC-II+ IKDC but not NK cross-present MHC class I-restricted antigens derived from MCMV-infected targets to CD8+ T cells in vitro and in vivo. Our findings emphasize the unique nature of IKDC as a killer antigen-presenting cell directly linking innate and adaptive immunity. ©2009 American Association for Cancer Research.en_HK
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleIFN-producing killer dendritic cells are antigen-presenting cells endowed with T-cell cross-priming capacityen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, C:camchan@hku.hken_HK
dc.identifier.authorityChan, C=rp01311en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1158/0008-5472.CAN-09-0508en_HK
dc.identifier.pmid19679552-
dc.identifier.pmcidPMC2761009-
dc.identifier.scopuseid_2-s2.0-69249120194en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69249120194&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume69en_HK
dc.identifier.issue16en_HK
dc.identifier.spage6607en_HK
dc.identifier.epage6614en_HK
dc.identifier.eissn1538-7445-
dc.identifier.isiWOS:000269064600031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPletneva, M=6507650441en_HK
dc.identifier.scopusauthoridFan, H=7402553804en_HK
dc.identifier.scopusauthoridPark, JJ=35085224200en_HK
dc.identifier.scopusauthoridRadojcic, V=14720082600en_HK
dc.identifier.scopusauthoridJie, C=7006488232en_HK
dc.identifier.scopusauthoridYu, Y=7406250017en_HK
dc.identifier.scopusauthoridChan, C=12240386600en_HK
dc.identifier.scopusauthoridRedwood, A=6603217918en_HK
dc.identifier.scopusauthoridPardoll, D=7005961020en_HK
dc.identifier.scopusauthoridHousseau, F=6603256765en_HK

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