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Article: Anxiolytic-like action of orally administered dl-tetrahydropalmatine in elevated plus-maze

TitleAnxiolytic-like action of orally administered dl-tetrahydropalmatine in elevated plus-maze
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2003
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbp
Citation
Progress In Neuro-Psychopharmacology And Biological Psychiatry, 2003, v. 27 n. 5, p. 775-779 How to Cite?
Abstractdl-Tetrahydropalmatine (dl-THP), a naturally occurring alkaloid, has been intensively studied for its sedative and hypnotic effects. Putative explanation for its mechanism and target of action involves the dopaminergic neurotransmission system. In view of the close interactions between the dopaminergic and the GABAergic neurons in the amygdala, pharmacological effects of dl-THP were tested for activity at the GABA A receptor benzodiazepine site (BDS). Effects of dl-THP were examined in mice employing the elevated plus-maze, the holeboard and the horizontal-wire tests. In the elevated plus-maze, mice treated with low doses of dl-THP (0.5-10 mg/kg) exhibited significant increase in the percentage of entries and time spent in open arms without altering the number of closed-arm entries when compared to the control group, indicative of its selective anxiolytic effect. In the holeboard and horizontal wire tests, where exploratory behavior and potential muscle relaxant effect were assessed, respectively, only mice treated with as much as 50 mg/kg dl-THP manifested sedation and myorelaxation, as observed in the significant decrease in the number of head dips and the decrease in the percentage of mice grasping wire in comparison to control. Notably, coadministration of the BDS antagonist flumazenil abolished the dl-THP-induced anxiolysis as seen in the reversal of the increase of both the number of entries and time spent in open arms back to basal levels in the elevated plus-maze test. The results suggest that dl-THP at defined low dosages acts as anxiolytics in mice, and the BDS mediates, at least in part, such anxiolytic effect of dl-THP. © 2003 Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/90993
ISSN
2015 Impact Factor: 4.361
2015 SCImago Journal Rankings: 1.794
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, WCen_HK
dc.contributor.authorZheng, Hen_HK
dc.contributor.authorHuen, Men_HK
dc.contributor.authorLaw, SLen_HK
dc.contributor.authorXue, Hen_HK
dc.date.accessioned2010-09-17T10:11:26Z-
dc.date.available2010-09-17T10:11:26Z-
dc.date.issued2003en_HK
dc.identifier.citationProgress In Neuro-Psychopharmacology And Biological Psychiatry, 2003, v. 27 n. 5, p. 775-779en_HK
dc.identifier.issn0278-5846en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90993-
dc.description.abstractdl-Tetrahydropalmatine (dl-THP), a naturally occurring alkaloid, has been intensively studied for its sedative and hypnotic effects. Putative explanation for its mechanism and target of action involves the dopaminergic neurotransmission system. In view of the close interactions between the dopaminergic and the GABAergic neurons in the amygdala, pharmacological effects of dl-THP were tested for activity at the GABA A receptor benzodiazepine site (BDS). Effects of dl-THP were examined in mice employing the elevated plus-maze, the holeboard and the horizontal-wire tests. In the elevated plus-maze, mice treated with low doses of dl-THP (0.5-10 mg/kg) exhibited significant increase in the percentage of entries and time spent in open arms without altering the number of closed-arm entries when compared to the control group, indicative of its selective anxiolytic effect. In the holeboard and horizontal wire tests, where exploratory behavior and potential muscle relaxant effect were assessed, respectively, only mice treated with as much as 50 mg/kg dl-THP manifested sedation and myorelaxation, as observed in the significant decrease in the number of head dips and the decrease in the percentage of mice grasping wire in comparison to control. Notably, coadministration of the BDS antagonist flumazenil abolished the dl-THP-induced anxiolysis as seen in the reversal of the increase of both the number of entries and time spent in open arms back to basal levels in the elevated plus-maze test. The results suggest that dl-THP at defined low dosages acts as anxiolytics in mice, and the BDS mediates, at least in part, such anxiolytic effect of dl-THP. © 2003 Elsevier Science Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbpen_HK
dc.relation.ispartofProgress in Neuro-Psychopharmacology and Biological Psychiatryen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAdministration, Oralen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnti-Anxiety Agents - administration & dosage - chemistryen_HK
dc.subject.meshAnxiety - drug therapyen_HK
dc.subject.meshBerberine Alkaloids - administration & dosage - chemistryen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMaze Learning - drug effects - physiologyen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred ICRen_HK
dc.subject.meshStereoisomerismen_HK
dc.titleAnxiolytic-like action of orally administered dl-tetrahydropalmatine in elevated plus-mazeen_HK
dc.typeArticleen_HK
dc.identifier.emailHuen, M:huen.michael@hku.hken_HK
dc.identifier.authorityHuen, M=rp01336en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0278-5846(03)00108-8en_HK
dc.identifier.pmid12921909-
dc.identifier.scopuseid_2-s2.0-0041630968en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0041630968&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue5en_HK
dc.identifier.spage775en_HK
dc.identifier.epage779en_HK
dc.identifier.isiWOS:000185187900008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, WC=7201504434en_HK
dc.identifier.scopusauthoridZheng, H=7403441193en_HK
dc.identifier.scopusauthoridHuen, M=23004751500en_HK
dc.identifier.scopusauthoridLaw, SL=7202242075en_HK
dc.identifier.scopusauthoridXue, H=37041779000en_HK

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