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Article: Integrins regulate NMDA receptor-mediated synaptic currents

TitleIntegrins regulate NMDA receptor-mediated synaptic currents
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2003
PublisherAmerican Physiological Society
Citation
Journal of Neurophysiology, 2003, v. 89 n. 5, p. 2874-2878 How to Cite?
AbstractSynapses contain high concentrations of integrins, adhesion receptors known to influence the operation of neighboring transmembrane proteins. Evidence that integrins are important for consolidation of long-term potentiation suggests that these adhesion proteins may modulate activities of synaptic glutamate receptors. The present study provides a first test of the possibility that integrins modulate synaptic N-methyl-D-aspartate (NMDA)-type glutamate receptor activities. Excitatory postsynaptic currents (EPSCs) were recorded with whole cell clamp from hippocampal slices in which AMPA-type glutamate receptors and GABAA receptors were pharmacologically blocked. Microperfusion of the peptide integrin ligand gly-arg-gly-asp-ser-pro (GRGDSP) caused an approximately twofold increase in the amplitude and duration of NMDA receptor-gated synaptic currents. Control peptides had no effect. Paired-pulse facilitation was unchanged, indicating that the ligand did not modify neurotransmitter release probabilities. Infusion of the Src kinase antagonist PP2 but not the control drug 4-amino-7-phenylpyrazolo[3,4-d]pyrimidine eliminated the enhancing effect of GRGDSP. Integrins regulate Src kinases that are known to phosphorylate NMDA receptors. It is concluded that integrins act through this route to exert potent modulatory effects on the operation of NMDA receptors.
Persistent Identifierhttp://hdl.handle.net/10722/90988
ISSN
2015 Impact Factor: 2.653
2015 SCImago Journal Rankings: 2.230
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, Ben_HK
dc.contributor.authorArai, ACen_HK
dc.contributor.authorLynch, Gen_HK
dc.contributor.authorGall, CMen_HK
dc.date.accessioned2010-09-17T10:11:22Z-
dc.date.available2010-09-17T10:11:22Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal of Neurophysiology, 2003, v. 89 n. 5, p. 2874-2878en_HK
dc.identifier.issn0022-3077en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90988-
dc.description.abstractSynapses contain high concentrations of integrins, adhesion receptors known to influence the operation of neighboring transmembrane proteins. Evidence that integrins are important for consolidation of long-term potentiation suggests that these adhesion proteins may modulate activities of synaptic glutamate receptors. The present study provides a first test of the possibility that integrins modulate synaptic N-methyl-D-aspartate (NMDA)-type glutamate receptor activities. Excitatory postsynaptic currents (EPSCs) were recorded with whole cell clamp from hippocampal slices in which AMPA-type glutamate receptors and GABAA receptors were pharmacologically blocked. Microperfusion of the peptide integrin ligand gly-arg-gly-asp-ser-pro (GRGDSP) caused an approximately twofold increase in the amplitude and duration of NMDA receptor-gated synaptic currents. Control peptides had no effect. Paired-pulse facilitation was unchanged, indicating that the ligand did not modify neurotransmitter release probabilities. Infusion of the Src kinase antagonist PP2 but not the control drug 4-amino-7-phenylpyrazolo[3,4-d]pyrimidine eliminated the enhancing effect of GRGDSP. Integrins regulate Src kinases that are known to phosphorylate NMDA receptors. It is concluded that integrins act through this route to exert potent modulatory effects on the operation of NMDA receptors.en_HK
dc.languageengen_HK
dc.publisherAmerican Physiological Societyen_HK
dc.relation.ispartofJournal of Neurophysiologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleIntegrins regulate NMDA receptor-mediated synaptic currentsen_HK
dc.typeArticleen_HK
dc.identifier.emailLin, B:blin@hku.hken_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1152/jn.00783.2002en_HK
dc.identifier.pmid12740418-
dc.identifier.scopuseid_2-s2.0-0038216785en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038216785&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume89en_HK
dc.identifier.issue5en_HK
dc.identifier.spage2874en_HK
dc.identifier.epage2878en_HK
dc.identifier.isiWOS:000182741200050-

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