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Article: Nociceptin receptor activation produces nitric oxide-mediated systemic hypotension

TitleNociceptin receptor activation produces nitric oxide-mediated systemic hypotension
Authors
KeywordsSpecies Index: Animalia
Issue Date1999
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1999, v. 66 n. 6, p. PL99-PL104 How to Cite?
AbstractThe purpose of the present study was to investigate the effects of L- N5-(1-iminoethyl)-ornithine hydrochloride (L-NIO), an inhibitor of nitric oxide (NO) formation, and [Phe1-Ψ(CH2-NH)-Gly2]Nociceptin(1-13)-NH2 (Phe-NOC), a nociceptin receptor antagonist, on the systemic vasodepressor response to nociceptin in the anesthetized rat. The systemic vasodepressor response to bolus intravenous (i.v.) injections of nociceptin was significantly reduced by L-NIO and Phe-NOC. The present data suggest activation of nociceptin receptors dilates the systemic vascular bed through a NO-dependent pathway. These data also demonstrate Phe-NOC is an efficacious and selective nociceptin receptor antagonist in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/90944
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, Ben_HK
dc.contributor.authorWaterman, Ren_HK
dc.contributor.authorLippton, Hen_HK
dc.date.accessioned2010-09-17T10:10:43Z-
dc.date.available2010-09-17T10:10:43Z-
dc.date.issued1999en_HK
dc.identifier.citationLife Sciences, 1999, v. 66 n. 6, p. PL99-PL104en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90944-
dc.description.abstractThe purpose of the present study was to investigate the effects of L- N5-(1-iminoethyl)-ornithine hydrochloride (L-NIO), an inhibitor of nitric oxide (NO) formation, and [Phe1-Ψ(CH2-NH)-Gly2]Nociceptin(1-13)-NH2 (Phe-NOC), a nociceptin receptor antagonist, on the systemic vasodepressor response to nociceptin in the anesthetized rat. The systemic vasodepressor response to bolus intravenous (i.v.) injections of nociceptin was significantly reduced by L-NIO and Phe-NOC. The present data suggest activation of nociceptin receptors dilates the systemic vascular bed through a NO-dependent pathway. These data also demonstrate Phe-NOC is an efficacious and selective nociceptin receptor antagonist in vivo.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.subjectSpecies Index: Animaliaen_HK
dc.titleNociceptin receptor activation produces nitric oxide-mediated systemic hypotensionen_HK
dc.typeArticleen_HK
dc.identifier.emailLin, B:blin@hku.hken_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0024-3205(99)00627-Xen_HK
dc.identifier.pmid10794074-
dc.identifier.scopuseid_2-s2.0-0002418273en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0002418273&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume66en_HK
dc.identifier.issue6en_HK
dc.identifier.spagePL99en_HK
dc.identifier.epagePL104en_HK
dc.identifier.isiWOS:000084726800012-

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