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Article: An adrenomedullin fragment retains the systemic vasodepressor activity of rat adrenomedullin

TitleAn adrenomedullin fragment retains the systemic vasodepressor activity of rat adrenomedullin
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1994
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal of Pharmacology, 1994, v. 260 n. 1, p. 1-4 How to Cite?
AbstractThe present study was undertaken to investigate the effects of human adrenomedullin, a newly discovered peptide present in normal human plasma, as well as a fragment of adrenomedullin, on systemic hemodynamics in the anesthetized rat. Intravenous (i.v.) bolus injections of rat adrenomedullin, rat adrenomedullin-(11-50), human adrenomedullin, and human adrenomedullin-(13-52) decreased mean systemic arterial pressure in a dose-dependent manner. Since rat adrenomedullin and human adrenomedullin did not decrease cardiac output, the decreases in systemic arterial pressure reflect dose-dependent reductions in systemic vascular resistance. The systemic vasodepressor responses to similar doses of the adrenomedullin fragments studied and to their respective parent adrenomedullin peptides were similar. The present data demonstrate that the entire adrenomedullin molecule is not required for full systemic vasodilator activity in vivo suggesting that rat adrenomedullin-(11-50) or a structurally similar peptide, if formed endogenously, could mediate the hemodynamic properties of adrenomedullin in vivo. Since rat adrenomedullin had significantly greater systemic vasodilator activity than human adrenomedullin at similar doses in the rat, the present data suggest that adrenomedullin has greater systemic vasodilator activity in its native species and that limited changes in the peptide's sequence confer markedly different vascular activity in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/90904
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLin, Ben_HK
dc.contributor.authorGao, Yen_HK
dc.contributor.authorChang, J-Ken_HK
dc.contributor.authorHeaton, Jen_HK
dc.contributor.authorHyman, Aen_HK
dc.contributor.authorLippton, Hen_HK
dc.date.accessioned2010-09-17T10:10:07Z-
dc.date.available2010-09-17T10:10:07Z-
dc.date.issued1994en_HK
dc.identifier.citationEuropean Journal of Pharmacology, 1994, v. 260 n. 1, p. 1-4en_HK
dc.identifier.issn0014-2999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90904-
dc.description.abstractThe present study was undertaken to investigate the effects of human adrenomedullin, a newly discovered peptide present in normal human plasma, as well as a fragment of adrenomedullin, on systemic hemodynamics in the anesthetized rat. Intravenous (i.v.) bolus injections of rat adrenomedullin, rat adrenomedullin-(11-50), human adrenomedullin, and human adrenomedullin-(13-52) decreased mean systemic arterial pressure in a dose-dependent manner. Since rat adrenomedullin and human adrenomedullin did not decrease cardiac output, the decreases in systemic arterial pressure reflect dose-dependent reductions in systemic vascular resistance. The systemic vasodepressor responses to similar doses of the adrenomedullin fragments studied and to their respective parent adrenomedullin peptides were similar. The present data demonstrate that the entire adrenomedullin molecule is not required for full systemic vasodilator activity in vivo suggesting that rat adrenomedullin-(11-50) or a structurally similar peptide, if formed endogenously, could mediate the hemodynamic properties of adrenomedullin in vivo. Since rat adrenomedullin had significantly greater systemic vasodilator activity than human adrenomedullin at similar doses in the rat, the present data suggest that adrenomedullin has greater systemic vasodilator activity in its native species and that limited changes in the peptide's sequence confer markedly different vascular activity in vivo.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_HK
dc.relation.ispartofEuropean Journal of Pharmacologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleAn adrenomedullin fragment retains the systemic vasodepressor activity of rat adrenomedullinen_HK
dc.typeArticleen_HK
dc.identifier.emailLin, B:blin@hku.hken_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0014-2999(94)90002-7en_HK
dc.identifier.pmid7957618-
dc.identifier.scopuseid_2-s2.0-0028338841en_HK
dc.identifier.volume260en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage4en_HK
dc.identifier.isiWOS:A1994PA02600001-

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