File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Integrin-driven actin polymerization consolidates long-term potentiation

TitleIntegrin-driven actin polymerization consolidates long-term potentiation
Authors
KeywordsSpecies Index: Animalia
Issue Date2006
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings of the National Academy of Sciences of the United States of America, 2006, v. 103 n. 14, p. 5579-5584 How to Cite?
AbstractLong-term potentiation (LTP), like memory, becomes progressively more resistant to disruption with time after its formation. Here we show that threshold conditions for inducing LTP cause a rapid, long-lasting increase in polymerized filamentous actin in dendritic spines of adult hippocampus. Two independent manipulations that reverse LTP disrupted this effect when applied shortly after induction but not 30 min later. Function-blocking antibodies to β1 family integrins selectively eliminated both actin polymerization and stabilization of LTP. We propose that the initial stages of consolidation involve integrin-driven events common to cells engaged in activities that require rapid morphological changes. © 2006 by The National Academy of Sciences of the USA.
Persistent Identifierhttp://hdl.handle.net/10722/90895
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKramár, EAen_HK
dc.contributor.authorLin, Ben_HK
dc.contributor.authorRex, CSen_HK
dc.contributor.authorGall, CMen_HK
dc.contributor.authorLynch, Gen_HK
dc.date.accessioned2010-09-17T10:09:59Z-
dc.date.available2010-09-17T10:09:59Z-
dc.date.issued2006en_HK
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2006, v. 103 n. 14, p. 5579-5584en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90895-
dc.description.abstractLong-term potentiation (LTP), like memory, becomes progressively more resistant to disruption with time after its formation. Here we show that threshold conditions for inducing LTP cause a rapid, long-lasting increase in polymerized filamentous actin in dendritic spines of adult hippocampus. Two independent manipulations that reverse LTP disrupted this effect when applied shortly after induction but not 30 min later. Function-blocking antibodies to β1 family integrins selectively eliminated both actin polymerization and stabilization of LTP. We propose that the initial stages of consolidation involve integrin-driven events common to cells engaged in activities that require rapid morphological changes. © 2006 by The National Academy of Sciences of the USA.en_HK
dc.languageengen_HK
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.subjectSpecies Index: Animaliaen_HK
dc.titleIntegrin-driven actin polymerization consolidates long-term potentiationen_HK
dc.typeArticleen_HK
dc.identifier.emailLin, B:blin@hku.hken_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1073/pnas.0601354103en_HK
dc.identifier.pmid16567651-
dc.identifier.pmcidPMC1459396-
dc.identifier.scopuseid_2-s2.0-33645795737en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645795737&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume103en_HK
dc.identifier.issue14en_HK
dc.identifier.spage5579en_HK
dc.identifier.epage5584en_HK
dc.identifier.isiWOS:000236636400061-
dc.identifier.f10001032023-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats