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Article: Hemopressin, a hemoglobin fragment, dilates the rat systemic vascular bed through release of nitric oxide

TitleHemopressin, a hemoglobin fragment, dilates the rat systemic vascular bed through release of nitric oxide
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides
Citation
Peptides, 2006, v. 27 n. 9, p. 2284-2288 How to Cite?
AbstractThe present study was undertaken to investigate the effects of intravenous (i.v.) administration of rat hemopressin (rHP), 30-1000 μg/kg, on systemic arterial pressure (SAP), cardiac output (CO) and systemic vascular resistance (SVR) in the anesthetized rat. Bolus i.v. injections of rHP produced mild decreases in SAP that were dose-dependent. Since CO was not altered, the decreases in SAP reflect reductions in SVR. The systemic vasodilator response to rHP was not subject to tachyphylaxis. The systemic vasodilator response to rHP was abolished by l-nitro-arginine methylester (l-NAME) but was not altered by meclofenamate. In addition, rHP lacked direct contractile and relaxant activity on isolated rat aortic rings (AA) and pulmonary arterial rings (PA). The present data suggest rHP dilates the rat systemic vascular bed through the endogenous release of nitric oxide (NO) independent of the formation of cyclooxygenase products including prostacyclin. It is possible rHP acts as an endogenous vasodilator substance to regulate local blood flow during clinical states of altered red cell turnover, microvascular disease and hemolysis. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/90848
ISSN
2015 Impact Factor: 2.535
2015 SCImago Journal Rankings: 1.128
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLippton, Hen_HK
dc.contributor.authorLin, Ben_HK
dc.contributor.authorGumusel, Ben_HK
dc.contributor.authorWitriol, Nen_HK
dc.contributor.authorWasserman, Aen_HK
dc.contributor.authorKnight, Men_HK
dc.date.accessioned2010-09-17T10:09:17Z-
dc.date.available2010-09-17T10:09:17Z-
dc.date.issued2006en_HK
dc.identifier.citationPeptides, 2006, v. 27 n. 9, p. 2284-2288en_HK
dc.identifier.issn0196-9781en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90848-
dc.description.abstractThe present study was undertaken to investigate the effects of intravenous (i.v.) administration of rat hemopressin (rHP), 30-1000 μg/kg, on systemic arterial pressure (SAP), cardiac output (CO) and systemic vascular resistance (SVR) in the anesthetized rat. Bolus i.v. injections of rHP produced mild decreases in SAP that were dose-dependent. Since CO was not altered, the decreases in SAP reflect reductions in SVR. The systemic vasodilator response to rHP was not subject to tachyphylaxis. The systemic vasodilator response to rHP was abolished by l-nitro-arginine methylester (l-NAME) but was not altered by meclofenamate. In addition, rHP lacked direct contractile and relaxant activity on isolated rat aortic rings (AA) and pulmonary arterial rings (PA). The present data suggest rHP dilates the rat systemic vascular bed through the endogenous release of nitric oxide (NO) independent of the formation of cyclooxygenase products including prostacyclin. It is possible rHP acts as an endogenous vasodilator substance to regulate local blood flow during clinical states of altered red cell turnover, microvascular disease and hemolysis. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptidesen_HK
dc.relation.ispartofPeptidesen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleHemopressin, a hemoglobin fragment, dilates the rat systemic vascular bed through release of nitric oxideen_HK
dc.typeArticleen_HK
dc.identifier.emailLin, B:blin@hku.hken_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.peptides.2006.04.010en_HK
dc.identifier.pmid16713023-
dc.identifier.scopuseid_2-s2.0-33746918358en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746918358&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue9en_HK
dc.identifier.spage2284en_HK
dc.identifier.epage2288en_HK
dc.identifier.isiWOS:000240379800030-

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