File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.neuron.2004.08.002
- Scopus: eid_2-s2.0-4143058073
- PMID: 15312647
- WOS: WOS:000223436400007
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Retinal ganglion cell type, size, and spacing can be specified independent of homotypic dendritic contacts
Title | Retinal ganglion cell type, size, and spacing can be specified independent of homotypic dendritic contacts |
---|---|
Authors | |
Keywords | Chemicals And Cas Registry Numbers |
Issue Date | 2004 |
Publisher | Cell Press. The Journal's web site is located at http://www.elsevier.com/locate/neuron |
Citation | Neuron, 2004, v. 43 n. 4, p. 475-485 How to Cite? |
Abstract | In Brn3b-/- mice, where 80% of retinal ganglion cells degenerate early in development, the remaining 20% include most or all ganglion cell types. Cells of the same type cover the retinal surface evenly but tile it incompletely, indicating that a regular mosaic and normal dendritic field size can be maintained in the absence of contact among homotypic cells. In Math5 -/- mice, where only ∼5% of ganglion cells are formed, the dendritic arbors of at least two types among the residual ganglion cells are indistinguishable from normal in shape and size, even though throughout development they are separated by millimeters from the nearest neighboring ganglion cell of the same type. It appears that the primary phenotype of retinal ganglion cells can develop without homotypic contact; dendritic repulsion may be an end-stage mechanism that fine-tunes the dendritic arbors for more efficient coverage of the retinal surface. |
Persistent Identifier | http://hdl.handle.net/10722/90842 |
ISSN | 2023 Impact Factor: 14.7 2023 SCImago Journal Rankings: 7.728 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lin, B | en_HK |
dc.contributor.author | Wang, SW | en_HK |
dc.contributor.author | Masland, RH | en_HK |
dc.date.accessioned | 2010-09-17T10:09:12Z | - |
dc.date.available | 2010-09-17T10:09:12Z | - |
dc.date.issued | 2004 | en_HK |
dc.identifier.citation | Neuron, 2004, v. 43 n. 4, p. 475-485 | en_HK |
dc.identifier.issn | 0896-6273 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/90842 | - |
dc.description.abstract | In Brn3b-/- mice, where 80% of retinal ganglion cells degenerate early in development, the remaining 20% include most or all ganglion cell types. Cells of the same type cover the retinal surface evenly but tile it incompletely, indicating that a regular mosaic and normal dendritic field size can be maintained in the absence of contact among homotypic cells. In Math5 -/- mice, where only ∼5% of ganglion cells are formed, the dendritic arbors of at least two types among the residual ganglion cells are indistinguishable from normal in shape and size, even though throughout development they are separated by millimeters from the nearest neighboring ganglion cell of the same type. It appears that the primary phenotype of retinal ganglion cells can develop without homotypic contact; dendritic repulsion may be an end-stage mechanism that fine-tunes the dendritic arbors for more efficient coverage of the retinal surface. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Cell Press. The Journal's web site is located at http://www.elsevier.com/locate/neuron | en_HK |
dc.relation.ispartof | Neuron | en_HK |
dc.subject | Chemicals And Cas Registry Numbers | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Basic Helix-Loop-Helix Transcription Factors | en_HK |
dc.subject.mesh | Cell Communication - genetics - physiology | en_HK |
dc.subject.mesh | Cell Count - methods | en_HK |
dc.subject.mesh | Cell Size - genetics - physiology | en_HK |
dc.subject.mesh | DNA-Binding Proteins - biosynthesis - genetics | en_HK |
dc.subject.mesh | Dendrites - genetics - physiology | en_HK |
dc.subject.mesh | Mice | en_HK |
dc.subject.mesh | Mice, Inbred C57BL | en_HK |
dc.subject.mesh | Mice, Knockout | en_HK |
dc.subject.mesh | Nerve Tissue Proteins - biosynthesis - genetics | en_HK |
dc.subject.mesh | Retinal Ganglion Cells - cytology - metabolism | en_HK |
dc.subject.mesh | Transcription Factor Brn-3 | en_HK |
dc.subject.mesh | Transcription Factor Brn-3B | en_HK |
dc.subject.mesh | Transcription Factors - biosynthesis - genetics | en_HK |
dc.title | Retinal ganglion cell type, size, and spacing can be specified independent of homotypic dendritic contacts | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lin, B:blin@hku.hk | en_HK |
dc.identifier.authority | Lin, B=rp01356 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.neuron.2004.08.002 | en_HK |
dc.identifier.pmid | 15312647 | - |
dc.identifier.scopus | eid_2-s2.0-4143058073 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-4143058073&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 43 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 475 | en_HK |
dc.identifier.epage | 485 | en_HK |
dc.identifier.isi | WOS:000223436400007 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Lin, B=36165916900 | en_HK |
dc.identifier.scopusauthorid | Wang, SW=7410338362 | en_HK |
dc.identifier.scopusauthorid | Masland, RH=7007167900 | en_HK |
dc.identifier.issnl | 0896-6273 | - |