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- Publisher Website: 10.1016/j.tibs.2009.09.001
- Scopus: eid_2-s2.0-75949124023
- PMID: 19875294
- WOS: WOS:000274714300005
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Article: Assembly of checkpoint and repair machineries at DNA damage sites
Title | Assembly of checkpoint and repair machineries at DNA damage sites |
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Authors | |
Keywords | Chemicals And Cas Registry Numbers |
Issue Date | 2010 |
Publisher | Elsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/tibs |
Citation | Trends In Biochemical Sciences, 2010, v. 35 n. 2, p. 101-108 How to Cite? |
Abstract | The remarkably coordinated nature of the DNA damage response pathway relies on numerous mechanisms that facilitate the assembly of checkpoint and repair factors at DNA breaks. Post-translational modifications on and around chromatin have critical roles in allowing the timely and sequential assembly of DNA damage responsive elements at the vicinity of DNA breaks. Notably, recent advances in forward genetics and proteomics-based approaches have enabled the identification of novel components within the DNA damage response pathway, providing a more comprehensive picture of the molecular network that assists in the detection and propagation of DNA damage signals. © 2009 Elsevier Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/90830 |
ISSN | 2023 Impact Factor: 11.6 2023 SCImago Journal Rankings: 4.074 |
PubMed Central ID | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Huen, MSY | en_HK |
dc.contributor.author | Chen, J | en_HK |
dc.date.accessioned | 2010-09-17T10:09:01Z | - |
dc.date.available | 2010-09-17T10:09:01Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Trends In Biochemical Sciences, 2010, v. 35 n. 2, p. 101-108 | en_HK |
dc.identifier.issn | 0968-0004 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/90830 | - |
dc.description.abstract | The remarkably coordinated nature of the DNA damage response pathway relies on numerous mechanisms that facilitate the assembly of checkpoint and repair factors at DNA breaks. Post-translational modifications on and around chromatin have critical roles in allowing the timely and sequential assembly of DNA damage responsive elements at the vicinity of DNA breaks. Notably, recent advances in forward genetics and proteomics-based approaches have enabled the identification of novel components within the DNA damage response pathway, providing a more comprehensive picture of the molecular network that assists in the detection and propagation of DNA damage signals. © 2009 Elsevier Ltd. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Elsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/tibs | en_HK |
dc.relation.ispartof | Trends in Biochemical Sciences | en_HK |
dc.subject | Chemicals And Cas Registry Numbers | en_HK |
dc.title | Assembly of checkpoint and repair machineries at DNA damage sites | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Huen, MSY:huen.michael@hku.hk | en_HK |
dc.identifier.authority | Huen, MSY=rp01336 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.tibs.2009.09.001 | en_HK |
dc.identifier.pmid | 19875294 | - |
dc.identifier.pmcid | PMC3209802 | - |
dc.identifier.scopus | eid_2-s2.0-75949124023 | en_HK |
dc.identifier.hkuros | 169510 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-75949124023&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 35 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 101 | en_HK |
dc.identifier.epage | 108 | en_HK |
dc.identifier.isi | WOS:000274714300005 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Huen, MSY=23004751500 | en_HK |
dc.identifier.scopusauthorid | Chen, J=35261693300 | en_HK |
dc.identifier.citeulike | 6199221 | - |
dc.identifier.issnl | 0968-0004 | - |