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Article: Single nucleotide polymorphisms in the regulatory regions of the HLA-DRB-expressed genes

TitleSingle nucleotide polymorphisms in the regulatory regions of the HLA-DRB-expressed genes
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/humimm
Citation
Human Immunology, 2005, v. 66 n. 3, p. 290-294 How to Cite?
AbstractDRB genes encode proteins that play an important role in the immune response, and their expressional regulation is crucial to the immune reaction. Sequence variation at the regulatory region can directly affect the gene expression level. The aim of the present study was to use Chinese samples to investigate the variation in the regulation region of the human leukocyte antigen (HLA)-DRB-expressed genes. Seventy- one single nucleotide polymorphisms (SNPs) were found in the four HLA-DRB-expressed genes. By comparing these data with SNPs in the U.S. National Center for Biotechnology Information dbSNP database, 69 SNPs (97.2%) were found to be novel. In addition, two genetic variations of insertion-deletion polymorphisms were discovered within the regulatory region of HLA-DRB1 gene. These polymorphisms can be used as resources of markers for association studies of complex diseases, for assessment of individual predisposition to diseases, and as research markers for population genetics and evolution. © American Society for Histocompatibility and Immunogenetics, 2005. Published by Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/90802
ISSN
2015 Impact Factor: 2.127
2015 SCImago Journal Rankings: 0.904
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFan, Xen_HK
dc.contributor.authorLan, Den_HK
dc.contributor.authorLin, Ben_HK
dc.contributor.authorXie, Yen_HK
dc.contributor.authorLiu, Zen_HK
dc.contributor.authorZhen, Gen_HK
dc.contributor.authorFu, Yen_HK
dc.contributor.authorXu, Aen_HK
dc.date.accessioned2010-09-17T10:08:36Z-
dc.date.available2010-09-17T10:08:36Z-
dc.date.issued2005en_HK
dc.identifier.citationHuman Immunology, 2005, v. 66 n. 3, p. 290-294en_HK
dc.identifier.issn0198-8859en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90802-
dc.description.abstractDRB genes encode proteins that play an important role in the immune response, and their expressional regulation is crucial to the immune reaction. Sequence variation at the regulatory region can directly affect the gene expression level. The aim of the present study was to use Chinese samples to investigate the variation in the regulation region of the human leukocyte antigen (HLA)-DRB-expressed genes. Seventy- one single nucleotide polymorphisms (SNPs) were found in the four HLA-DRB-expressed genes. By comparing these data with SNPs in the U.S. National Center for Biotechnology Information dbSNP database, 69 SNPs (97.2%) were found to be novel. In addition, two genetic variations of insertion-deletion polymorphisms were discovered within the regulatory region of HLA-DRB1 gene. These polymorphisms can be used as resources of markers for association studies of complex diseases, for assessment of individual predisposition to diseases, and as research markers for population genetics and evolution. © American Society for Histocompatibility and Immunogenetics, 2005. Published by Elsevier Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/humimmen_HK
dc.relation.ispartofHuman Immunologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleSingle nucleotide polymorphisms in the regulatory regions of the HLA-DRB-expressed genesen_HK
dc.typeArticleen_HK
dc.identifier.emailLin, B:blin@hku.hken_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.humimm.2004.11.003en_HK
dc.identifier.pmid15784467-
dc.identifier.scopuseid_2-s2.0-15444362499en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-15444362499&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume66en_HK
dc.identifier.issue3en_HK
dc.identifier.spage290en_HK
dc.identifier.epage294en_HK
dc.identifier.isiWOS:000228317100009-

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