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Article: Distribution coefficients of dietary sugars in artificial Candida biofilms

TitleDistribution coefficients of dietary sugars in artificial Candida biofilms
Authors
KeywordsCandida biofilms
Diffusion
HATR-FTIR
Sugars
Issue Date2009
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0301-486X
Citation
Mycopathologia, 2009, v. 167 n. 6, p. 325-331 How to Cite?
AbstractCandida species are the most important fungal pathogens in humans and cause a variety of superficial and systemic diseases. Biofilm formation is a major virulence attribute contributing to Candida pathogenicity. Although the concentration and distribution of nutrients as well as antifungals across the biofilm thickness play a pivotal role in the development and persistence of Candida biofilms, only limited information is available on the latter aspects of Candida biofilms. Therefore, we attempted to characterize the diffusion coefficient (De) of common dietary sugars such as glucose, galactose, and sucrose in Candida albicans biofilms using horizontal attenuated total reflection-Fourier transform infrared spectroscopy (HATR-FTIR). Artificial Candida biofilms were formed using agarose polymers. De of three sugars tested, glucose, galactose, and sucrose in this artificial Candida biofilm model was found to be 4.08E-06 ± 3.63E-08, 4.08E-06 ± 3.70E-08, and 5.38E-06 ± 4.52E-08 cm2 s-1, respectively. We demonstrate here the utility of HATR-FTIR for the determination of diffusion of solutes such as dietary sugars across Candida biofilms. © 2009 Springer Science+Business Media B.V.
Persistent Identifierhttp://hdl.handle.net/10722/90754
ISSN
2015 Impact Factor: 1.671
2015 SCImago Journal Rankings: 0.720
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants Council, RGCHKU 7624/06M
Funding Information:

This work was supported by the Hong Kong Research Grants Council, RGC No. HKU 7624/06M.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorSeneviratne, CJen_HK
dc.contributor.authorZhang, Ten_HK
dc.contributor.authorFang, HHPen_HK
dc.contributor.authorJin, LJen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-09-17T10:07:47Z-
dc.date.available2010-09-17T10:07:47Z-
dc.date.issued2009en_HK
dc.identifier.citationMycopathologia, 2009, v. 167 n. 6, p. 325-331en_HK
dc.identifier.issn0301-486Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/90754-
dc.description.abstractCandida species are the most important fungal pathogens in humans and cause a variety of superficial and systemic diseases. Biofilm formation is a major virulence attribute contributing to Candida pathogenicity. Although the concentration and distribution of nutrients as well as antifungals across the biofilm thickness play a pivotal role in the development and persistence of Candida biofilms, only limited information is available on the latter aspects of Candida biofilms. Therefore, we attempted to characterize the diffusion coefficient (De) of common dietary sugars such as glucose, galactose, and sucrose in Candida albicans biofilms using horizontal attenuated total reflection-Fourier transform infrared spectroscopy (HATR-FTIR). Artificial Candida biofilms were formed using agarose polymers. De of three sugars tested, glucose, galactose, and sucrose in this artificial Candida biofilm model was found to be 4.08E-06 ± 3.63E-08, 4.08E-06 ± 3.70E-08, and 5.38E-06 ± 4.52E-08 cm2 s-1, respectively. We demonstrate here the utility of HATR-FTIR for the determination of diffusion of solutes such as dietary sugars across Candida biofilms. © 2009 Springer Science+Business Media B.V.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0301-486Xen_HK
dc.relation.ispartofMycopathologiaen_HK
dc.subjectCandida biofilmsen_HK
dc.subjectDiffusionen_HK
dc.subjectHATR-FTIRen_HK
dc.subjectSugarsen_HK
dc.subject.meshBiofilmsen_HK
dc.subject.meshCandida - growth & development - metabolismen_HK
dc.subject.meshDietary Sucrose - metabolismen_HK
dc.subject.meshGalactose - metabolismen_HK
dc.subject.meshGlucose - metabolismen_HK
dc.subject.meshSpectroscopy, Fourier Transform Infrareden_HK
dc.subject.meshSucrose - metabolismen_HK
dc.titleDistribution coefficients of dietary sugars in artificial Candida biofilmsen_HK
dc.typeArticleen_HK
dc.identifier.emailSeneviratne, CJ:jaya@hku.hken_HK
dc.identifier.emailZhang, T:zhangt@hkucc.hku.hken_HK
dc.identifier.emailFang, HHP:hrechef@hkucc.hku.hken_HK
dc.identifier.emailJin, LJ:ljjin@hkucc.hku.hken_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySeneviratne, CJ=rp01372en_HK
dc.identifier.authorityZhang, T=rp00211en_HK
dc.identifier.authorityFang, HHP=rp00115en_HK
dc.identifier.authorityJin, LJ=rp00028en_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11046-009-9184-xen_HK
dc.identifier.pmid19199075en_HK
dc.identifier.scopuseid_2-s2.0-67349117324en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349117324&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume167en_HK
dc.identifier.issue6en_HK
dc.identifier.spage325en_HK
dc.identifier.epage331en_HK
dc.identifier.isiWOS:000265825400004-
dc.publisher.placeNetherlandsen_HK
dc.relation.projectCandida biofilms: molecular mechanisms and clinical implications-
dc.identifier.scopusauthoridSeneviratne, CJ=6701897753en_HK
dc.identifier.scopusauthoridZhang, T=24470677400en_HK
dc.identifier.scopusauthoridFang, HHP=7402542625en_HK
dc.identifier.scopusauthoridJin, LJ=7403328850en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.citeulike4029263-

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