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Article: Effect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in rabbit mandibular distraction osteogenesis: a histological and immunohistochemical study

TitleEffect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in rabbit mandibular distraction osteogenesis: a histological and immunohistochemical study
Authors
KeywordsBone matrix metalloproteinase
Distraction osteogenesis
Immunohistochemistry
Mandible
Rabbit
Tissue inhibitor of matrix metalloproteinase
Issue Date2006
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcms
Citation
Journal of Cranio-Maxillofacial Surgery, 2006, v. 34 n. 5, p. 277-282 How to Cite?
AbstractBackground: Bone matrix metalloproteinases are capable of degrading bone matrix during the remodelling, and their degradation activities can be down regulated by the tissue inhibitors of matrix metalloproteinases. This study evaluated the influence of exogenous tissue inhibitor of matrix metalloproteinase-1 on the expression of matrix metalloproteinases and endogenous tissue inhibitor of matrix metalloproteinases in mandibular distraction osteogenesis. Material and Methods: Fifteen New Zealand white rabbits were assigned to three groups: a negative control; a sham control group implanted with a collagen sheet; and an experimental group implanted with recombinant human tissue inhibitor of matrix metalloproteinase-1 impregnated in a collagen sheet. Rabbits were sacrificed at 6 weeks, 12 weeks and 24 weeks of consolidation. Results: Major expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases was observed at the early stage of consolidation, only positive signals of tissue inhibitors of matrix metalloproteinases were observed at 24 weeks. The addition of recombinant human tissue inhibitor of matrix metalloproteinases-1 did not affect bone maturation and remodelling. Conclusions: An equilibrium of bone formation and resorption was reached at 24 weeks of consolidation in the rabbit mandible. No obvious influence of recombinant human tissue inhibitor of matrix metalloproteinase-1 on bone remodelling of mandibular distraction osteogenesis was noted. © 2006 European Association for Cranio-Maxillofacial Surgery.
Persistent Identifierhttp://hdl.handle.net/10722/90753
ISSN
2015 Impact Factor: 1.592
2015 SCImago Journal Rankings: 1.010
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, Len_HK
dc.contributor.authorMa, Len_HK
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2010-09-17T10:07:47Z-
dc.date.available2010-09-17T10:07:47Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal of Cranio-Maxillofacial Surgery, 2006, v. 34 n. 5, p. 277-282en_HK
dc.identifier.issn1010-5182en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90753-
dc.description.abstractBackground: Bone matrix metalloproteinases are capable of degrading bone matrix during the remodelling, and their degradation activities can be down regulated by the tissue inhibitors of matrix metalloproteinases. This study evaluated the influence of exogenous tissue inhibitor of matrix metalloproteinase-1 on the expression of matrix metalloproteinases and endogenous tissue inhibitor of matrix metalloproteinases in mandibular distraction osteogenesis. Material and Methods: Fifteen New Zealand white rabbits were assigned to three groups: a negative control; a sham control group implanted with a collagen sheet; and an experimental group implanted with recombinant human tissue inhibitor of matrix metalloproteinase-1 impregnated in a collagen sheet. Rabbits were sacrificed at 6 weeks, 12 weeks and 24 weeks of consolidation. Results: Major expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases was observed at the early stage of consolidation, only positive signals of tissue inhibitors of matrix metalloproteinases were observed at 24 weeks. The addition of recombinant human tissue inhibitor of matrix metalloproteinases-1 did not affect bone maturation and remodelling. Conclusions: An equilibrium of bone formation and resorption was reached at 24 weeks of consolidation in the rabbit mandible. No obvious influence of recombinant human tissue inhibitor of matrix metalloproteinase-1 on bone remodelling of mandibular distraction osteogenesis was noted. © 2006 European Association for Cranio-Maxillofacial Surgery.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcmsen_HK
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgeryen_HK
dc.subjectBone matrix metalloproteinaseen_HK
dc.subjectDistraction osteogenesisen_HK
dc.subjectImmunohistochemistryen_HK
dc.subjectMandibleen_HK
dc.subjectRabbiten_HK
dc.subjectTissue inhibitor of matrix metalloproteinaseen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Remodeling - drug effectsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMandible - drug effects - pathology - surgeryen_HK
dc.subject.meshMatrix Metalloproteinase 1 - drug effectsen_HK
dc.subject.meshModels, Animalen_HK
dc.subject.meshOsteogenesis, Distraction - methodsen_HK
dc.subject.meshProtease Inhibitors - pharmacologyen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshTissue Inhibitor of Metalloproteinase-1 - pharmacologyen_HK
dc.titleEffect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in rabbit mandibular distraction osteogenesis: a histological and immunohistochemical studyen_HK
dc.typeArticleen_HK
dc.identifier.emailZheng, L: lwzheng@hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailCheung, L: lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityCheung, L=rp00013en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jcms.2006.02.005en_HK
dc.identifier.pmid16777428-
dc.identifier.scopuseid_2-s2.0-33745240973en_HK
dc.identifier.hkuros123846-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745240973&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue5en_HK
dc.identifier.spage277en_HK
dc.identifier.epage282en_HK
dc.identifier.isiWOS:000239374500004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridMa, L=36072648200en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK

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