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Article: Evaluation of recombinant human bone morphogenetic protein-2 in mandibular distraction osteogenesis in rabbits: Effect of dosage and number of doses on formation of bone

TitleEvaluation of recombinant human bone morphogenetic protein-2 in mandibular distraction osteogenesis in rabbits: Effect of dosage and number of doses on formation of bone
Authors
KeywordsBMP
Distraction
Mandible
Osteogenesis
Issue Date2006
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjom
Citation
British Journal Of Oral And Maxillofacial Surgery, 2006, v. 44 n. 6, p. 487-494 How to Cite?
AbstractWe evaluated the dose- and time-dependent response of recombinant human bone morphogenetic protein-2 (rhBMP-2) to the formation of bone in mandibular distraction osteogenesis. Twenty-one adult white New Zealand rabbits (3.0-3.8 kg) were used to establish the mandibular distraction model, 18 of which completed the experiment. Eight rabbits were given rhBMP-2 360 μg and eight 1080 μg; two were given no rhBMP-2. The fluids were injected into the regenerating bone at three different time sequences (days 5, 8, and 11 of active distraction; days 5 and 11 of active distraction; and day 11 of active distraction alone). After four weeks of consolidation, the specimens were harvested and examined radiographically by micro-computed tomography (micro-CT), and histologically. The formation and remodelling of bone in distraction osteogenesis was significantly increased by the addition of rhBMP-2, and the increase was dose-dependent. There was no significant difference between different dosage regimens. A single injection of rhBMP-2 at the end of the distraction phase was as effective as multiple injections. © 2005 The British Association of Oral and Maxillofacial Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/90752
ISSN
2015 Impact Factor: 1.237
2015 SCImago Journal Rankings: 0.887
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, LWen_HK
dc.contributor.authorWong, MCMen_HK
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2010-09-17T10:07:46Z-
dc.date.available2010-09-17T10:07:46Z-
dc.date.issued2006en_HK
dc.identifier.citationBritish Journal Of Oral And Maxillofacial Surgery, 2006, v. 44 n. 6, p. 487-494en_HK
dc.identifier.issn0266-4356en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90752-
dc.description.abstractWe evaluated the dose- and time-dependent response of recombinant human bone morphogenetic protein-2 (rhBMP-2) to the formation of bone in mandibular distraction osteogenesis. Twenty-one adult white New Zealand rabbits (3.0-3.8 kg) were used to establish the mandibular distraction model, 18 of which completed the experiment. Eight rabbits were given rhBMP-2 360 μg and eight 1080 μg; two were given no rhBMP-2. The fluids were injected into the regenerating bone at three different time sequences (days 5, 8, and 11 of active distraction; days 5 and 11 of active distraction; and day 11 of active distraction alone). After four weeks of consolidation, the specimens were harvested and examined radiographically by micro-computed tomography (micro-CT), and histologically. The formation and remodelling of bone in distraction osteogenesis was significantly increased by the addition of rhBMP-2, and the increase was dose-dependent. There was no significant difference between different dosage regimens. A single injection of rhBMP-2 at the end of the distraction phase was as effective as multiple injections. © 2005 The British Association of Oral and Maxillofacial Surgeons.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjomen_HK
dc.relation.ispartofBritish Journal of Oral and Maxillofacial Surgeryen_HK
dc.subjectBMPen_HK
dc.subjectDistractionen_HK
dc.subjectMandibleen_HK
dc.subjectOsteogenesisen_HK
dc.subject.meshBone Morphogenetic Proteins - administration and dosage - pharmacology-
dc.subject.meshMandible - drug effects - radiography - surgery-
dc.subject.meshOsteogenesis - drug effects-
dc.subject.meshOsteogenesis, Distraction-
dc.subject.meshRecombinant Proteins - administration and dosage - pharmacology-
dc.titleEvaluation of recombinant human bone morphogenetic protein-2 in mandibular distraction osteogenesis in rabbits: Effect of dosage and number of doses on formation of boneen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0266-4356&volume=44&issue=6&spage=487&epage=494&date=2006&atitle=Evaluation+of+recombinant+human+bone+morphogenetic+protein-2+in+mandibular+distraction+osteogenesis+in+rabbits:+effect+of+dosage+and+number+of+doses+on+formation+of+bone-
dc.identifier.emailZheng, LW: lwzheng@hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailCheung, LK: lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bjoms.2005.09.005en_HK
dc.identifier.pmid16233939-
dc.identifier.scopuseid_2-s2.0-33750434887en_HK
dc.identifier.hkuros125781-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750434887&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue6en_HK
dc.identifier.spage487en_HK
dc.identifier.epage494en_HK
dc.identifier.isiWOS:000242554400004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridWong, MCM=54680484600en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK

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