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Article: Effect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in mandibular distraction osteogenesis in rabbits: A computed tomographic study

TitleEffect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in mandibular distraction osteogenesis in rabbits: A computed tomographic study
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2006
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjom
Citation
British Journal Of Oral And Maxillofacial Surgery, 2006, v. 44 n. 1, p. 5-11 How to Cite?
AbstractMatrix metalloproteinases (MMPs), together with their tissue inhibitors (TIMPs), are responsible for the controlled degradation of collagen in bone. We studied the long-term stability of the regenerated bone formed by distraction osteogenesis, and the effect of recombinant human TIMP-1 on the remodelling of bone formed by mandibular distraction osteogenesis in rabbits. Nine rabbits were subjected to distraction osteogenesis of the mandible and divided into three groups: a control group with no collagen implanted; a sham-control group with a collagen sheet implanted; and an experimental group with a collagen sheet impregnated with rhTIMP-1 implanted. Computed tomograms were taken at weeks 4, 12, and 24 after distraction, and micro-computed tomograms and histological examinations were made at week 24. There was no significant resorption of regenerated bone at the site of distraction in any group after 6 months of consolidation, suggesting that the regenerated bone formed by distraction osteogenesis is stable. We found no obvious influence of rhTIMP-1 in the collagen sheet on the bony regenerate after 6 months of consolidation. © 2005 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/90736
ISSN
2015 Impact Factor: 1.237
2015 SCImago Journal Rankings: 0.887
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, LKen_HK
dc.contributor.authorZheng, LWen_HK
dc.date.accessioned2010-09-17T10:07:31Z-
dc.date.available2010-09-17T10:07:31Z-
dc.date.issued2006en_HK
dc.identifier.citationBritish Journal Of Oral And Maxillofacial Surgery, 2006, v. 44 n. 1, p. 5-11en_HK
dc.identifier.issn0266-4356en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90736-
dc.description.abstractMatrix metalloproteinases (MMPs), together with their tissue inhibitors (TIMPs), are responsible for the controlled degradation of collagen in bone. We studied the long-term stability of the regenerated bone formed by distraction osteogenesis, and the effect of recombinant human TIMP-1 on the remodelling of bone formed by mandibular distraction osteogenesis in rabbits. Nine rabbits were subjected to distraction osteogenesis of the mandible and divided into three groups: a control group with no collagen implanted; a sham-control group with a collagen sheet implanted; and an experimental group with a collagen sheet impregnated with rhTIMP-1 implanted. Computed tomograms were taken at weeks 4, 12, and 24 after distraction, and micro-computed tomograms and histological examinations were made at week 24. There was no significant resorption of regenerated bone at the site of distraction in any group after 6 months of consolidation, suggesting that the regenerated bone formed by distraction osteogenesis is stable. We found no obvious influence of rhTIMP-1 in the collagen sheet on the bony regenerate after 6 months of consolidation. © 2005 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjomen_HK
dc.relation.ispartofBritish Journal of Oral and Maxillofacial Surgeryen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Regeneration - drug effectsen_HK
dc.subject.meshBone Remodeling - drug effectsen_HK
dc.subject.meshBone Resorption - pathology - radiographyen_HK
dc.subject.meshCollagenen_HK
dc.subject.meshDrug Carriersen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMandible - drug effects - pathology - radiography - surgeryen_HK
dc.subject.meshMembranes, Artificialen_HK
dc.subject.meshOsteogenesis, Distractionen_HK
dc.subject.meshProtease Inhibitors - therapeutic useen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshRecombinant Proteinsen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTissue Inhibitor of Metalloproteinase-1 - therapeutic useen_HK
dc.subject.meshTomography, X-Ray Computeden_HK
dc.titleEffect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in mandibular distraction osteogenesis in rabbits: A computed tomographic studyen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, LK:lkcheung@hkucc.hku.hken_HK
dc.identifier.emailZheng, LW:lwzheng@hku.hken_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bjoms.2005.07.013en_HK
dc.identifier.pmid16203065en_HK
dc.identifier.scopuseid_2-s2.0-30544440162en_HK
dc.identifier.hkuros114009-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-30544440162&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue1en_HK
dc.identifier.spage5en_HK
dc.identifier.epage11en_HK
dc.identifier.isiWOS:000235040900003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK

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