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- Publisher Website: 10.1016/j.bjoms.2005.07.013
- Scopus: eid_2-s2.0-30544440162
- PMID: 16203065
- WOS: WOS:000235040900003
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Article: Effect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in mandibular distraction osteogenesis in rabbits: A computed tomographic study
Title | Effect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in mandibular distraction osteogenesis in rabbits: A computed tomographic study |
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Authors | |
Keywords | Chemicals And Cas Registry Numbers |
Issue Date | 2006 |
Publisher | Churchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjom |
Citation | British Journal Of Oral And Maxillofacial Surgery, 2006, v. 44 n. 1, p. 5-11 How to Cite? |
Abstract | Matrix metalloproteinases (MMPs), together with their tissue inhibitors (TIMPs), are responsible for the controlled degradation of collagen in bone. We studied the long-term stability of the regenerated bone formed by distraction osteogenesis, and the effect of recombinant human TIMP-1 on the remodelling of bone formed by mandibular distraction osteogenesis in rabbits. Nine rabbits were subjected to distraction osteogenesis of the mandible and divided into three groups: a control group with no collagen implanted; a sham-control group with a collagen sheet implanted; and an experimental group with a collagen sheet impregnated with rhTIMP-1 implanted. Computed tomograms were taken at weeks 4, 12, and 24 after distraction, and micro-computed tomograms and histological examinations were made at week 24. There was no significant resorption of regenerated bone at the site of distraction in any group after 6 months of consolidation, suggesting that the regenerated bone formed by distraction osteogenesis is stable. We found no obvious influence of rhTIMP-1 in the collagen sheet on the bony regenerate after 6 months of consolidation. © 2005 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/90736 |
ISSN | 2023 Impact Factor: 1.7 2023 SCImago Journal Rankings: 0.572 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Cheung, LK | en_HK |
dc.contributor.author | Zheng, LW | en_HK |
dc.date.accessioned | 2010-09-17T10:07:31Z | - |
dc.date.available | 2010-09-17T10:07:31Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | British Journal Of Oral And Maxillofacial Surgery, 2006, v. 44 n. 1, p. 5-11 | en_HK |
dc.identifier.issn | 0266-4356 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/90736 | - |
dc.description.abstract | Matrix metalloproteinases (MMPs), together with their tissue inhibitors (TIMPs), are responsible for the controlled degradation of collagen in bone. We studied the long-term stability of the regenerated bone formed by distraction osteogenesis, and the effect of recombinant human TIMP-1 on the remodelling of bone formed by mandibular distraction osteogenesis in rabbits. Nine rabbits were subjected to distraction osteogenesis of the mandible and divided into three groups: a control group with no collagen implanted; a sham-control group with a collagen sheet implanted; and an experimental group with a collagen sheet impregnated with rhTIMP-1 implanted. Computed tomograms were taken at weeks 4, 12, and 24 after distraction, and micro-computed tomograms and histological examinations were made at week 24. There was no significant resorption of regenerated bone at the site of distraction in any group after 6 months of consolidation, suggesting that the regenerated bone formed by distraction osteogenesis is stable. We found no obvious influence of rhTIMP-1 in the collagen sheet on the bony regenerate after 6 months of consolidation. © 2005 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Churchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjom | en_HK |
dc.relation.ispartof | British Journal of Oral and Maxillofacial Surgery | en_HK |
dc.subject | Chemicals And Cas Registry Numbers | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Bone Regeneration - drug effects | en_HK |
dc.subject.mesh | Bone Remodeling - drug effects | en_HK |
dc.subject.mesh | Bone Resorption - pathology - radiography | en_HK |
dc.subject.mesh | Collagen | en_HK |
dc.subject.mesh | Drug Carriers | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Mandible - drug effects - pathology - radiography - surgery | en_HK |
dc.subject.mesh | Membranes, Artificial | en_HK |
dc.subject.mesh | Osteogenesis, Distraction | en_HK |
dc.subject.mesh | Protease Inhibitors - therapeutic use | en_HK |
dc.subject.mesh | Rabbits | en_HK |
dc.subject.mesh | Recombinant Proteins | en_HK |
dc.subject.mesh | Time Factors | en_HK |
dc.subject.mesh | Tissue Inhibitor of Metalloproteinase-1 - therapeutic use | en_HK |
dc.subject.mesh | Tomography, X-Ray Computed | en_HK |
dc.title | Effect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in mandibular distraction osteogenesis in rabbits: A computed tomographic study | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Cheung, LK:lkcheung@hkucc.hku.hk | en_HK |
dc.identifier.email | Zheng, LW:lwzheng@hku.hk | en_HK |
dc.identifier.authority | Cheung, LK=rp00013 | en_HK |
dc.identifier.authority | Zheng, LW=rp01411 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.bjoms.2005.07.013 | en_HK |
dc.identifier.pmid | 16203065 | en_HK |
dc.identifier.scopus | eid_2-s2.0-30544440162 | en_HK |
dc.identifier.hkuros | 114009 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-30544440162&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 44 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 5 | en_HK |
dc.identifier.epage | 11 | en_HK |
dc.identifier.isi | WOS:000235040900003 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Cheung, LK=7102302747 | en_HK |
dc.identifier.scopusauthorid | Zheng, LW=11241247300 | en_HK |
dc.identifier.issnl | 0266-4356 | - |