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Article: Effect of Nicotine on Gene Expression of Angiogenic and Osteogenic Factors in a Rabbit Model of Bone Regeneration

TitleEffect of Nicotine on Gene Expression of Angiogenic and Osteogenic Factors in a Rabbit Model of Bone Regeneration
Authors
Issue Date2010
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
Citation
Journal Of Oral And Maxillofacial Surgery, 2010, v. 68 n. 4, p. 777-781 How to Cite?
AbstractPurpose: This study aims to evaluate the influence of nicotine on the gene expression of osteogenic and angiogenic factors in bone regeneration by use of a nicotine-compromised rabbit model of mandibular lengthening. Materials and Methods: Thirty adult New Zealand white rabbits were randomly assigned to the nicotine group or the control group. The total nicotine or placebo exposure time for all animals was 7 weeks. Unilateral mandibular distraction osteogenesis was performed. Five animals in each group were sacrificed at day 5, day 11, and day 18, respectively, after commencement of active distraction. The distraction regenerate samples were harvested, and the messenger ribonucleic acid expression of bone transforming growth factor β1, platelet-derived growth factor A, and basic fibroblast growth factor was assayed by real-time polymerase chain reaction analysis. Results: The messenger ribonucleic acid expression of transforming growth factor β1, platelet-derived growth factor A, and basic fibroblast growth factor was significantly inhibited by nicotine exposure at a variety of time points. Conclusions: The presence of nicotine inhibited the gene expression of angiogenic and osteogenic factors resulting in compromised bone regeneration. © 2010 American Association of Oral and Maxillofacial Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/90731
ISSN
2015 Impact Factor: 1.631
2015 SCImago Journal Rankings: 0.824
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong KongHKU200507176099
Funding Information:

This study was supported by the Small Project Funding Programme (reference code HKU200507176099) from The University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorMa, Len_HK
dc.contributor.authorZheng, LWen_HK
dc.contributor.authorSham, MHen_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2010-09-17T10:07:27Z-
dc.date.available2010-09-17T10:07:27Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery, 2010, v. 68 n. 4, p. 777-781en_HK
dc.identifier.issn0278-2391en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90731-
dc.description.abstractPurpose: This study aims to evaluate the influence of nicotine on the gene expression of osteogenic and angiogenic factors in bone regeneration by use of a nicotine-compromised rabbit model of mandibular lengthening. Materials and Methods: Thirty adult New Zealand white rabbits were randomly assigned to the nicotine group or the control group. The total nicotine or placebo exposure time for all animals was 7 weeks. Unilateral mandibular distraction osteogenesis was performed. Five animals in each group were sacrificed at day 5, day 11, and day 18, respectively, after commencement of active distraction. The distraction regenerate samples were harvested, and the messenger ribonucleic acid expression of bone transforming growth factor β1, platelet-derived growth factor A, and basic fibroblast growth factor was assayed by real-time polymerase chain reaction analysis. Results: The messenger ribonucleic acid expression of transforming growth factor β1, platelet-derived growth factor A, and basic fibroblast growth factor was significantly inhibited by nicotine exposure at a variety of time points. Conclusions: The presence of nicotine inhibited the gene expression of angiogenic and osteogenic factors resulting in compromised bone regeneration. © 2010 American Association of Oral and Maxillofacial Surgeons.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jomsen_HK
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_HK
dc.subject.meshBone Regeneration - drug effects - genetics-
dc.subject.meshGene Expression - drug effects-
dc.subject.meshNicotine - adverse effects-
dc.subject.meshNicotinic Agonists - adverse effects-
dc.subject.meshTransforming Growth Factor beta1 - antagonists and inhibitors-
dc.titleEffect of Nicotine on Gene Expression of Angiogenic and Osteogenic Factors in a Rabbit Model of Bone Regenerationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-2391&volume=68&issue=4&spage=777&epage=781&date=2010&atitle=Effect+of+nicotine+on+gene+expression+of+angiogenic+and+osteogenic+factors+in+a+rabbit+model+of+bone+regeneration-
dc.identifier.emailZheng, LW:lwzheng@hku.hken_HK
dc.identifier.emailSham, MH:mhsham@hkucc.hku.hken_HK
dc.identifier.emailCheung, LK:lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.identifier.authoritySham, MH=rp00380en_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.joms.2009.07.102en_HK
dc.identifier.pmid20307763-
dc.identifier.scopuseid_2-s2.0-77949457870en_HK
dc.identifier.hkuros169851-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949457870&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume68en_HK
dc.identifier.issue4en_HK
dc.identifier.spage777en_HK
dc.identifier.epage781en_HK
dc.identifier.isiWOS:000276579200011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMa, L=36071946000en_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridSham, MH=7003729109en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK

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