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Article: Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in an experimental model

TitleEffect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in an experimental model
Authors
KeywordsDistraction osteogenesis
Mandible
Rabbit
Recombinant human bone morphogenetic protein-2
Issue Date2006
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jcraniofacialsurgery.com
Citation
Journal Of Craniofacial Surgery, 2006, v. 17 n. 1, p. 100-108 How to Cite?
AbstractThis study evaluates the effect of recombinant human (rh) bone morphogenetic protein (BMP)-2 on mandibular distraction at normal and rapid distraction rates. This study also determines the feasibility of compensating for the increased distraction rate by the addition of rhBMP-2 while maintaining the quality of the distraction regenerate. Twenty-four New Zealand white rabbits were divided into 2 groups, 1 treated at a normal distraction rate (0.9 mm/d) and the other at a rapid distraction rate (2.7 mm/d). At the end of the active distraction period, rhBMP-2 was injected into distraction regenerate, and the contralateral side was used as a control. The distraction regenerates were analyzed by plain radiography, microcomputed tomography, and mechanical testing. The results showed that rhBMP-2 can promote bone formation at both rapid and normal distraction rates. At week 2 and week 4 of consolidation, bone volumes in the BMP-injection sides were significantly higher than in the control sides, but no statistically significant difference was observed between the BMP-injection sides of the rapid and normal distraction groups. At week 8 of consolidation, mechanical testing demonstrated no significant difference of the failure load and stiffness between the BMP-injection and control sides. In conclusion, the study indicates that rhBMP-2 can enhance bone ossification at both normal and rapid distraction rates. The addition of rhBMP-2 can compensate for the rapid distraction rate in mandibular distraction osteogenesis. However, in the long term, the bone quality and stiffness of the distraction regeneration was not influenced by rhBMP-2. Copyright © Mutaz B. Habal, MD.
Persistent Identifierhttp://hdl.handle.net/10722/90706
ISSN
2015 Impact Factor: 0.7
2015 SCImago Journal Rankings: 0.443
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, LKen_HK
dc.contributor.authorZheng, LWen_HK
dc.date.accessioned2010-09-17T10:07:05Z-
dc.date.available2010-09-17T10:07:05Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Craniofacial Surgery, 2006, v. 17 n. 1, p. 100-108en_HK
dc.identifier.issn1049-2275en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90706-
dc.description.abstractThis study evaluates the effect of recombinant human (rh) bone morphogenetic protein (BMP)-2 on mandibular distraction at normal and rapid distraction rates. This study also determines the feasibility of compensating for the increased distraction rate by the addition of rhBMP-2 while maintaining the quality of the distraction regenerate. Twenty-four New Zealand white rabbits were divided into 2 groups, 1 treated at a normal distraction rate (0.9 mm/d) and the other at a rapid distraction rate (2.7 mm/d). At the end of the active distraction period, rhBMP-2 was injected into distraction regenerate, and the contralateral side was used as a control. The distraction regenerates were analyzed by plain radiography, microcomputed tomography, and mechanical testing. The results showed that rhBMP-2 can promote bone formation at both rapid and normal distraction rates. At week 2 and week 4 of consolidation, bone volumes in the BMP-injection sides were significantly higher than in the control sides, but no statistically significant difference was observed between the BMP-injection sides of the rapid and normal distraction groups. At week 8 of consolidation, mechanical testing demonstrated no significant difference of the failure load and stiffness between the BMP-injection and control sides. In conclusion, the study indicates that rhBMP-2 can enhance bone ossification at both normal and rapid distraction rates. The addition of rhBMP-2 can compensate for the rapid distraction rate in mandibular distraction osteogenesis. However, in the long term, the bone quality and stiffness of the distraction regeneration was not influenced by rhBMP-2. Copyright © Mutaz B. Habal, MD.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jcraniofacialsurgery.comen_HK
dc.relation.ispartofJournal of Craniofacial Surgeryen_HK
dc.subjectDistraction osteogenesisen_HK
dc.subjectMandibleen_HK
dc.subjectRabbiten_HK
dc.subjectRecombinant human bone morphogenetic protein-2en_HK
dc.titleEffect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in an experimental modelen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, LK:lkcheung@hkucc.hku.hken_HK
dc.identifier.emailZheng, LW:lwzheng@hku.hken_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.scs.0000188744.06723.1fen_HK
dc.identifier.scopuseid_2-s2.0-33645807396en_HK
dc.identifier.hkuros114008-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645807396&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue1en_HK
dc.identifier.spage100en_HK
dc.identifier.epage108en_HK
dc.identifier.isiWOS:000235065900021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK

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