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Article: Angiogenesis is enhanced by continuous traction in rabbit mandibular distraction osteogenesis

TitleAngiogenesis is enhanced by continuous traction in rabbit mandibular distraction osteogenesis
Authors
KeywordsAngiogenesis
Basic Fibroblast Growth Factor
Biomechanics
Distraction Osteogenesis
Vascular Endothelial Growth Factor
Issue Date2009
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcms
Citation
Journal Of Cranio-Maxillofacial Surgery, 2009, v. 37 n. 7, p. 405-411 How to Cite?
AbstractBackground: Distraction osteogenesis is a controlled surgical procedure that initiates a regenerative process and uses mechanical strain to enhance the biological responses of the injured tissues to create new bone. To test the hypothesis that high frequency mechanical traction can enhance the angiogenesis in distraction regenerate, we compared the neo-vessel formation and gene expression of the angiogenic mediators between intermittent and continuous distraction osteogenesis. Material and methods: Eighty adult New Zealand white rabbits were randomly assigned to the continuous and intermittent distraction groups. Unilateral mandibular osteotomy was performed and custom-designed manual-driven or autodriven distractor was bridged over the osteotomy segments. Animals were sacrificed at day-6, day-10, day-14 and day-21 after osteotomy and examined with histology, immunohistochemistry and real-time polymerase chain reaction (PCR). Results: Histological examination showed a more advanced bone formation in the continuous distraction group associated with significantly increased micro-vascular density and up-regulated mRNA expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). Conclusion: We concluded that the high frequency traction provides a proper mechanical environment for angiogenesis contributing to the enhanced bone formation likely to be through up-regulation of the angiogenic mediators. © 2009 European Association for Cranio-Maxillofacial Surgery.
Persistent Identifierhttp://hdl.handle.net/10722/90686
ISSN
2015 Impact Factor: 1.592
2015 SCImago Journal Rankings: 1.010
ISI Accession Number ID
Funding AgencyGrant Number
AO Research Fund of the AO foundation05-C43
Funding Information:

This study was supported by the AO Research Fund of the AO foundation (project no. 05-C43). We appreciate the valuable technical assistance provided by the Laboratory Animal Unit of the Li Ka Shing, Faculty of Medicine and the Centralized Research Laboratories of the Faculty of Dentistry.

References

 

DC FieldValueLanguage
dc.contributor.authorZheng, LWen_HK
dc.contributor.authorMa, Len_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2010-09-17T10:06:47Z-
dc.date.available2010-09-17T10:06:47Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Cranio-Maxillofacial Surgery, 2009, v. 37 n. 7, p. 405-411en_HK
dc.identifier.issn1010-5182en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90686-
dc.description.abstractBackground: Distraction osteogenesis is a controlled surgical procedure that initiates a regenerative process and uses mechanical strain to enhance the biological responses of the injured tissues to create new bone. To test the hypothesis that high frequency mechanical traction can enhance the angiogenesis in distraction regenerate, we compared the neo-vessel formation and gene expression of the angiogenic mediators between intermittent and continuous distraction osteogenesis. Material and methods: Eighty adult New Zealand white rabbits were randomly assigned to the continuous and intermittent distraction groups. Unilateral mandibular osteotomy was performed and custom-designed manual-driven or autodriven distractor was bridged over the osteotomy segments. Animals were sacrificed at day-6, day-10, day-14 and day-21 after osteotomy and examined with histology, immunohistochemistry and real-time polymerase chain reaction (PCR). Results: Histological examination showed a more advanced bone formation in the continuous distraction group associated with significantly increased micro-vascular density and up-regulated mRNA expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). Conclusion: We concluded that the high frequency traction provides a proper mechanical environment for angiogenesis contributing to the enhanced bone formation likely to be through up-regulation of the angiogenic mediators. © 2009 European Association for Cranio-Maxillofacial Surgery.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcmsen_HK
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgeryen_HK
dc.subjectAngiogenesisen_HK
dc.subjectBasic Fibroblast Growth Factoren_HK
dc.subjectBiomechanicsen_HK
dc.subjectDistraction Osteogenesisen_HK
dc.subjectVascular Endothelial Growth Factoren_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Regeneration - physiologyen_HK
dc.subject.meshFibroblast Growth Factor 2 - genetics - metabolismen_HK
dc.subject.meshGene Expression Regulation - physiologyen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMandible - blood supply - physiology - surgeryen_HK
dc.subject.meshMicrovessels - anatomy & histology - growth & development - metabolismen_HK
dc.subject.meshNeovascularization, Physiologic - physiologyen_HK
dc.subject.meshOsteogenesis, Distraction - instrumentation - methodsen_HK
dc.subject.meshRNA, Messenger - analysisen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTraction - instrumentation - methodsen_HK
dc.subject.meshVascular Endothelial Growth Factor A - genetics - metabolismen_HK
dc.subject.meshWound Healing - physiologyen_HK
dc.titleAngiogenesis is enhanced by continuous traction in rabbit mandibular distraction osteogenesisen_HK
dc.typeArticleen_HK
dc.identifier.emailZheng, LW:lwzheng@hku.hken_HK
dc.identifier.emailCheung, LK:lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jcms.2009.03.007en_HK
dc.identifier.pmid19428266-
dc.identifier.scopuseid_2-s2.0-69249215217en_HK
dc.identifier.hkuros166619-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69249215217&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue7en_HK
dc.identifier.spage405en_HK
dc.identifier.epage411en_HK
dc.identifier.isiWOS:000270623300008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridMa, L=36071946000en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK

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