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Article: Isolation of a homodimeric lectin with antifungal and antiviral activities from red kidney bean (Phaseolus vulgaris) seeds

TitleIsolation of a homodimeric lectin with antifungal and antiviral activities from red kidney bean (Phaseolus vulgaris) seeds
Authors
KeywordsSpecies Index: Bacteria (Microorganisms)
Coprinus Comatus
Fungi
Fusarium
Fusarium Oxysporum
Human Immunodeficiency Virus
Human Immunodeficiency Virus 1
Phaseolus (Angiosperm)
Phaseolus Vulgaris
Rhizoctonia
Thanatephorus Cucumeris
Issue Date2001
Citation
Journal Of Protein Chemistry, 2001, v. 20 n. 5, p. 367-375 How to Cite?
AbstractA homodimeric lectin adsorbed on Affi-gel blue gel and CM-Sepharose and possessing a molecular weight of 67 kDa was isolated from red kidney beans. The hemagglutinating activity of this lectin was inhibited by glycoproteins but not by simple sugars. The lectin manifested inhibitory activity on human immunodeficiency virus-1 reverse transcriptase and α-glucosidase. The N-terminal sequence of the lectin exhibited some differences from previously reported lectins from Phaseolus vulgaris but showed some similarity to chitinases. It exerted a suppressive effect on growth of the fungal species Fusarium oxysporum, Coprinus comatus, and Rhizoctonia solani. The lectin had low ribonuclease and negligible translation-inhibitory activities.
Persistent Identifierhttp://hdl.handle.net/10722/90664
ISSN
2005 Impact Factor: 1.487
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYe, XYen_HK
dc.contributor.authorNg, TBen_HK
dc.contributor.authorTsang, PWKen_HK
dc.contributor.authorWang, Jen_HK
dc.date.accessioned2010-09-17T10:06:27Z-
dc.date.available2010-09-17T10:06:27Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Protein Chemistry, 2001, v. 20 n. 5, p. 367-375en_HK
dc.identifier.issn0277-8033en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90664-
dc.description.abstractA homodimeric lectin adsorbed on Affi-gel blue gel and CM-Sepharose and possessing a molecular weight of 67 kDa was isolated from red kidney beans. The hemagglutinating activity of this lectin was inhibited by glycoproteins but not by simple sugars. The lectin manifested inhibitory activity on human immunodeficiency virus-1 reverse transcriptase and α-glucosidase. The N-terminal sequence of the lectin exhibited some differences from previously reported lectins from Phaseolus vulgaris but showed some similarity to chitinases. It exerted a suppressive effect on growth of the fungal species Fusarium oxysporum, Coprinus comatus, and Rhizoctonia solani. The lectin had low ribonuclease and negligible translation-inhibitory activities.en_HK
dc.languageengen_HK
dc.relation.ispartofJournal of Protein Chemistryen_HK
dc.subjectSpecies Index: Bacteria (Microorganisms)en_HK
dc.subjectCoprinus Comatusen_HK
dc.subjectFungien_HK
dc.subjectFusariumen_HK
dc.subjectFusarium Oxysporumen_HK
dc.subjectHuman Immunodeficiency Virusen_HK
dc.subjectHuman Immunodeficiency Virus 1en_HK
dc.subjectPhaseolus (Angiosperm)en_HK
dc.subjectPhaseolus Vulgarisen_HK
dc.subjectRhizoctoniaen_HK
dc.subjectThanatephorus Cucumerisen_HK
dc.subject.meshAmino Acid Sequenceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntifungal Agents - isolation & purification - pharmacologyen_HK
dc.subject.meshAntiviral Agents - isolation & purification - pharmacologyen_HK
dc.subject.meshCoprinus - drug effectsen_HK
dc.subject.meshFusarium - drug effectsen_HK
dc.subject.meshHIV Reverse Transcriptase - antagonists & inhibitorsen_HK
dc.subject.meshHemagglutination - drug effectsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshPhaseolus - genetics - metabolismen_HK
dc.subject.meshPhytohemagglutinins - isolation & purification - pharmacologyen_HK
dc.subject.meshPlant Lectinsen_HK
dc.subject.meshProtein Biosynthesis - drug effectsen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshReverse Transcriptase Inhibitors - isolation & purification - pharmacologyen_HK
dc.subject.meshRhizoctonia - drug effectsen_HK
dc.subject.meshSeeds - genetics - metabolismen_HK
dc.subject.meshSequence Alignmenten_HK
dc.titleIsolation of a homodimeric lectin with antifungal and antiviral activities from red kidney bean (Phaseolus vulgaris) seedsen_HK
dc.typeArticleen_HK
dc.identifier.emailTsang, PWK:pwktsang@hku.hken_HK
dc.identifier.authorityTsang, PWK=rp01388en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1023/A:1012276619686en_HK
dc.identifier.pmid11732688-
dc.identifier.scopuseid_2-s2.0-0034762513en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034762513&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue5en_HK
dc.identifier.spage367en_HK
dc.identifier.epage375en_HK
dc.identifier.isiWOS:000172137100005-
dc.identifier.scopusauthoridYe, XY=7401899210en_HK
dc.identifier.scopusauthoridNg, TB=36041665600en_HK
dc.identifier.scopusauthoridTsang, PWK=8334953500en_HK
dc.identifier.scopusauthoridWang, J=7701314238en_HK

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