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Article: Inhibitory effect of nicotine on bone regeneration in mandibular distraction osteogenesis

TitleInhibitory effect of nicotine on bone regeneration in mandibular distraction osteogenesis
Authors
KeywordsBone healing
Distraction osteogenesis
Nicotine
Rabbit
Issue Date2007
Citation
Frontiers In Bioscience, 2007, v. 12 n. 9, p. 3256-3262 How to Cite?
AbstractNicotine is the main chemical component in tobacco products and its effect on bone healing remains controversial. Distraction osteogenesis is an endogenous tissue engineering technique which provides an excellent platform to study bone healing and regeneration. This study aims to evaluate the dose dependent effect of nicotine on bone regeneration using a rabbit model of mandibular distraction osteogenesis. Twenty New Zealand white rabbits were randomly assigned to four groups: sham control, placebo control, low dose nicotine (0.75g) and high dose nicotine (1.5g). 60-day time release nicotine pellets or placebo pellets were implanted in the neck subcutaneous tissue of the rabbits one week before osteotomy was performed. Then after three day latency, eleven day active distraction and four week consolidation, the animals were sacrificed and subjected to examinations by radiography, micro-computed tomography and histological analysis. The significantly lower bone volume and appearance of chondrocytes in the high dose nicotine group indicated that the bone regeneration of distraction osteogenesis was compromised by high dose nicotine exposure.
Persistent Identifierhttp://hdl.handle.net/10722/90627
ISSN
2015 Impact Factor: 2.484
2015 SCImago Journal Rankings: 1.583
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, Len_HK
dc.contributor.authorZheng, Len_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2010-09-17T10:05:54Z-
dc.date.available2010-09-17T10:05:54Z-
dc.date.issued2007en_HK
dc.identifier.citationFrontiers In Bioscience, 2007, v. 12 n. 9, p. 3256-3262en_HK
dc.identifier.issn1093-9946en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90627-
dc.description.abstractNicotine is the main chemical component in tobacco products and its effect on bone healing remains controversial. Distraction osteogenesis is an endogenous tissue engineering technique which provides an excellent platform to study bone healing and regeneration. This study aims to evaluate the dose dependent effect of nicotine on bone regeneration using a rabbit model of mandibular distraction osteogenesis. Twenty New Zealand white rabbits were randomly assigned to four groups: sham control, placebo control, low dose nicotine (0.75g) and high dose nicotine (1.5g). 60-day time release nicotine pellets or placebo pellets were implanted in the neck subcutaneous tissue of the rabbits one week before osteotomy was performed. Then after three day latency, eleven day active distraction and four week consolidation, the animals were sacrificed and subjected to examinations by radiography, micro-computed tomography and histological analysis. The significantly lower bone volume and appearance of chondrocytes in the high dose nicotine group indicated that the bone regeneration of distraction osteogenesis was compromised by high dose nicotine exposure.en_HK
dc.languageengen_HK
dc.relation.ispartofFrontiers in Bioscienceen_HK
dc.subjectBone healingen_HK
dc.subjectDistraction osteogenesisen_HK
dc.subjectNicotineen_HK
dc.subjectRabbiten_HK
dc.titleInhibitory effect of nicotine on bone regeneration in mandibular distraction osteogenesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1093-9946&volume=12&spage=3256&epage=62&date=2007&atitle=Inhibitory+effect+of+nicotine+on+bone+regeneration+in+mandibular+distraction+osteogenesis-
dc.identifier.emailZheng, LW:lwzheng@hku.hken_HK
dc.identifier.emailCheung, LK:lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2741/2309en_HK
dc.identifier.pmid17485296-
dc.identifier.scopuseid_2-s2.0-34347271295en_HK
dc.identifier.hkuros127037-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34347271295&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue9en_HK
dc.identifier.spage3256en_HK
dc.identifier.epage3262en_HK
dc.identifier.isiWOS:000246157900039-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMa, L=36072648200en_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK

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