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Article: Effect of distraction rates on expression of bone morphogenetic proteins in rabbit mandibular distraction osteogenesis

TitleEffect of distraction rates on expression of bone morphogenetic proteins in rabbit mandibular distraction osteogenesis
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2006
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcms
Citation
Journal Of Cranio-Maxillofacial Surgery, 2006, v. 34 n. 5, p. 263-269 How to Cite?
AbstractBackground: The expression of bone morphogenetic proteins can be regarded as an indicator for biological interaction in distraction osteogenesis. It was hypothesized that different distraction rates may produce different patterns of BMP expression. Material and methods: This study compared the expression of BMP-2, -4 and -7 at routine (0.9 mm once daily) and rapid (2.7 mm once daily) distraction rates using the rabbit mandibular lengthening model. Mandibular samples were harvested at days 1, 7 and 14 of consolidation. Results: The expression of BMP-2 and BMP-4 was found throughout the experiment, their expression intensity and location being essentially similar, whereas BMP-7 had not been expressed. Expression of BMP-2 and -4 was more intense at the routine distraction rate than at the rapid distraction rate. Conclusions: BMP-7 had no expression during the consolidation period of mandibular distraction. The change in the mechanical environment created by different distraction rates led to different expression of BMP-2 and -4. In the early consolidation stage the biological environment for bone formation created by distraction at a routine rate was superior to that created by the rapid distraction rate. © 2006 European Association for Cranio-Maxillofacial Surgery.
Persistent Identifierhttp://hdl.handle.net/10722/90603
ISSN
2015 Impact Factor: 1.592
2015 SCImago Journal Rankings: 1.010
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, LKen_HK
dc.contributor.authorZheng, LWen_HK
dc.contributor.authorMA, Len_HK
dc.date.accessioned2010-09-17T10:05:33Z-
dc.date.available2010-09-17T10:05:33Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Cranio-Maxillofacial Surgery, 2006, v. 34 n. 5, p. 263-269en_HK
dc.identifier.issn1010-5182en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90603-
dc.description.abstractBackground: The expression of bone morphogenetic proteins can be regarded as an indicator for biological interaction in distraction osteogenesis. It was hypothesized that different distraction rates may produce different patterns of BMP expression. Material and methods: This study compared the expression of BMP-2, -4 and -7 at routine (0.9 mm once daily) and rapid (2.7 mm once daily) distraction rates using the rabbit mandibular lengthening model. Mandibular samples were harvested at days 1, 7 and 14 of consolidation. Results: The expression of BMP-2 and BMP-4 was found throughout the experiment, their expression intensity and location being essentially similar, whereas BMP-7 had not been expressed. Expression of BMP-2 and -4 was more intense at the routine distraction rate than at the rapid distraction rate. Conclusions: BMP-7 had no expression during the consolidation period of mandibular distraction. The change in the mechanical environment created by different distraction rates led to different expression of BMP-2 and -4. In the early consolidation stage the biological environment for bone formation created by distraction at a routine rate was superior to that created by the rapid distraction rate. © 2006 European Association for Cranio-Maxillofacial Surgery.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcmsen_HK
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgeryen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Morphogenetic Protein 2en_HK
dc.subject.meshBone Morphogenetic Protein 4en_HK
dc.subject.meshBone Morphogenetic Protein 7en_HK
dc.subject.meshBone Morphogenetic Proteins - analysis - metabolismen_HK
dc.subject.meshBone Regeneration - physiologyen_HK
dc.subject.meshGoatsen_HK
dc.subject.meshMandible - cytology - metabolism - surgeryen_HK
dc.subject.meshModels, Animalen_HK
dc.subject.meshOsteogenesis, Distraction - methodsen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshRecombinant Proteins - metabolismen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTransforming Growth Factor beta - analysis - metabolismen_HK
dc.titleEffect of distraction rates on expression of bone morphogenetic proteins in rabbit mandibular distraction osteogenesisen_HK
dc.typeArticleen_HK
dc.identifier.emailCHEUNG, LK:lkcheung@hkucc.hku.hken_HK
dc.identifier.emailZHENG, LW:lwzheng@hku.hken_HK
dc.identifier.authorityCHEUNG, LK=rp00013en_HK
dc.identifier.authorityZHENG, LW=rp01411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jcms.2006.02.004en_HK
dc.identifier.pmid16781161-
dc.identifier.scopuseid_2-s2.0-33745289098en_HK
dc.identifier.hkuros123847-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745289098&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue5en_HK
dc.identifier.spage263en_HK
dc.identifier.epage269en_HK
dc.identifier.isiWOS:000239374500002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCHEUNG, LK=7102302747en_HK
dc.identifier.scopusauthoridZHENG, LW=11241247300en_HK
dc.identifier.scopusauthoridMA, L=36071946000en_HK

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