File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Transgenic B7-H3 therapy induces tumor-specific immune response in human oral squamous cell cancer: an in vitro study

TitleTransgenic B7-H3 therapy induces tumor-specific immune response in human oral squamous cell cancer: an in vitro study
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2008
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/tripleo
Citation
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology And Endodontology, 2008, v. 106 n. 5, p. 721-728 How to Cite?
AbstractObjective: Tumors may present antigens to T cells but lack costimulatory signals which are necessary to initialize an effective immunologic response. This study aimed to develop a tumor cell-based cancer vaccine by genetically modifying oral squamous cell cancer (OSCC) cell line Tca8113 with human B7-H3 immunoglobulin, and to evaluate its efficacy in enhancing the tumor-specific immune response. Study design: Human B7-H3 gene was extracted from isolated T lymphocytes of healthy volunteers. Tumor cell vaccine TCV-hB7-H3 and mock control were prepared by transfecting Tca8113 cells with B7-H3 or mock vector. After being stimulated with TCV-hB7-H3 or mock control, the proliferation, IFN-μ expression, and cytotoxicity of the T cells were assessed. Results: The Tca8113 cells transfected with human B7-H3 significantly enhanced the proliferation, IFN-μ expression, and cytotoxicity of the T cells. Conclusions: Genetically modified OSCC cells encoding B7-H3 enhance the induction of tumor specific immune response. © 2008 Mosby, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/90590
ISSN
2011 Impact Factor: 1.457
ISI Accession Number ID
Funding AgencyGrant Number
National Nature Science Foundation30672335
Guangdong Provincial Nature Science Foundation06027977
Shenzhen Science and Technology Program200601008
Funding Information:

Supported by National Nature Science Foundation (30672335), Guangdong Provincial Nature Science Foundation (06027977), and Shenzhen Science and Technology Program (200601008). Tca8113 cell line kindly provided by Shanghai Jiaotong University.

References

 

DC FieldValueLanguage
dc.contributor.authorYang, HYen_HK
dc.contributor.authorChu, Men_HK
dc.contributor.authorZheng, Len_HK
dc.contributor.authorZwahlen, RAen_HK
dc.contributor.authorLuo, Jen_HK
dc.contributor.authorZou, DHen_HK
dc.contributor.authorSun, STen_HK
dc.date.accessioned2010-09-17T10:05:21Z-
dc.date.available2010-09-17T10:05:21Z-
dc.date.issued2008en_HK
dc.identifier.citationOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology And Endodontology, 2008, v. 106 n. 5, p. 721-728en_HK
dc.identifier.issn1079-2104en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90590-
dc.description.abstractObjective: Tumors may present antigens to T cells but lack costimulatory signals which are necessary to initialize an effective immunologic response. This study aimed to develop a tumor cell-based cancer vaccine by genetically modifying oral squamous cell cancer (OSCC) cell line Tca8113 with human B7-H3 immunoglobulin, and to evaluate its efficacy in enhancing the tumor-specific immune response. Study design: Human B7-H3 gene was extracted from isolated T lymphocytes of healthy volunteers. Tumor cell vaccine TCV-hB7-H3 and mock control were prepared by transfecting Tca8113 cells with B7-H3 or mock vector. After being stimulated with TCV-hB7-H3 or mock control, the proliferation, IFN-μ expression, and cytotoxicity of the T cells were assessed. Results: The Tca8113 cells transfected with human B7-H3 significantly enhanced the proliferation, IFN-μ expression, and cytotoxicity of the T cells. Conclusions: Genetically modified OSCC cells encoding B7-H3 enhance the induction of tumor specific immune response. © 2008 Mosby, Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/tripleoen_HK
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAntigens, CD - genetics - therapeutic useen_HK
dc.subject.meshB7 Antigensen_HK
dc.subject.meshCancer Vaccines - genetics - therapeutic useen_HK
dc.subject.meshCarcinoma, Squamous Cell - drug therapy - immunologyen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshCell Proliferationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInterferons - biosynthesisen_HK
dc.subject.meshMouth Neoplasms - drug therapy - immunologyen_HK
dc.subject.meshReceptors, Immunologic - genetics - therapeutic useen_HK
dc.subject.meshT-Lymphocytes, Cytotoxic - immunology - metabolismen_HK
dc.subject.meshTransgenesen_HK
dc.titleTransgenic B7-H3 therapy induces tumor-specific immune response in human oral squamous cell cancer: an in vitro studyen_HK
dc.typeArticleen_HK
dc.identifier.emailZheng, L:lwzheng@hku.hken_HK
dc.identifier.emailZwahlen, RA:zwahlen@hku.hken_HK
dc.identifier.authorityZheng, L=rp01411en_HK
dc.identifier.authorityZwahlen, RA=rp00055en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.tripleo.2008.08.012en_HK
dc.identifier.pmid18929994-
dc.identifier.scopuseid_2-s2.0-53249113207en_HK
dc.identifier.hkuros156024-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-53249113207&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume106en_HK
dc.identifier.issue5en_HK
dc.identifier.spage721en_HK
dc.identifier.epage728en_HK
dc.identifier.isiWOS:000259973000019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYang, HY=7406556789en_HK
dc.identifier.scopusauthoridChu, M=37017042500en_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridZwahlen, RA=7004217269en_HK
dc.identifier.scopusauthoridLuo, J=35272549800en_HK
dc.identifier.scopusauthoridZou, DH=25222293600en_HK
dc.identifier.scopusauthoridSun, ST=25222309000en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats