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- Publisher Website: 10.1007/s00239-010-9344-0
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- PMID: 20437037
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Article: Circadian input kinases and their homologs in cyanobacteria: Evolutionary constraints versus architectural diversification
Title | Circadian input kinases and their homologs in cyanobacteria: Evolutionary constraints versus architectural diversification | ||||
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Authors | |||||
Keywords | CikA Constraints Divergence GAF Prokaryotes | ||||
Issue Date | 2010 | ||||
Publisher | Springer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00239 | ||||
Citation | Journal Of Molecular Evolution, 2010, v. 70 n. 5, p. 453-465 How to Cite? | ||||
Abstract | The circadian input kinase A (cikA) gene encodes a protein relaying environmental signal to the central circadian oscillator in cyanobacteria. The CikA protein has a variable architecture and usually consists of four tandemly arrayed domains: GAF, histidine kinase (HisKA), histidine kinase-like ATPase (HATPase-c), and a pseudo-receiver (REC). Among them, HisKA and HATPase-c are the least polymorphic, and REC is not present in heterocystic filamentous cyanobacteria. CikA contains several conserved motifs that are likely important for circadian function. There are at least three types of circadian systems, each of which possesses a different set of circadian genes. The originally described circadian system (kaiABC system) possesses both cikA and kaiA, while the others lack either only cikA (kaiABC Δ) or both (kaiBC). The results we obtained allowed us to approximate the time of the cikA origin to be about 2600-2200 MYA and the time of its loss in the species with the kaiABC Δ or kaiBC system between 1100 and 600 MYA. Circadian specialization of CikA, as opposed to its non-circadian homologs, is a result of several factors, including the unique conserved domain architecture and high evolutionary constraints of some domains and regions, which were previously identified as critical for the circadian function of the gene. © 2010 Springer Science+Business Media, LLC. | ||||
Persistent Identifier | http://hdl.handle.net/10722/90482 | ||||
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.905 | ||||
ISI Accession Number ID |
Funding Information: This study was supported by the University of Hong Kong start-up fund for VD. | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baca, I | en_HK |
dc.contributor.author | Sprockett, D | en_HK |
dc.contributor.author | Dvornyk, V | en_HK |
dc.date.accessioned | 2010-09-09T01:39:19Z | - |
dc.date.available | 2010-09-09T01:39:19Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Journal Of Molecular Evolution, 2010, v. 70 n. 5, p. 453-465 | en_HK |
dc.identifier.issn | 0022-2844 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/90482 | - |
dc.description.abstract | The circadian input kinase A (cikA) gene encodes a protein relaying environmental signal to the central circadian oscillator in cyanobacteria. The CikA protein has a variable architecture and usually consists of four tandemly arrayed domains: GAF, histidine kinase (HisKA), histidine kinase-like ATPase (HATPase-c), and a pseudo-receiver (REC). Among them, HisKA and HATPase-c are the least polymorphic, and REC is not present in heterocystic filamentous cyanobacteria. CikA contains several conserved motifs that are likely important for circadian function. There are at least three types of circadian systems, each of which possesses a different set of circadian genes. The originally described circadian system (kaiABC system) possesses both cikA and kaiA, while the others lack either only cikA (kaiABC Δ) or both (kaiBC). The results we obtained allowed us to approximate the time of the cikA origin to be about 2600-2200 MYA and the time of its loss in the species with the kaiABC Δ or kaiBC system between 1100 and 600 MYA. Circadian specialization of CikA, as opposed to its non-circadian homologs, is a result of several factors, including the unique conserved domain architecture and high evolutionary constraints of some domains and regions, which were previously identified as critical for the circadian function of the gene. © 2010 Springer Science+Business Media, LLC. | en_HK |
dc.language | eng | - |
dc.publisher | Springer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00239 | en_HK |
dc.relation.ispartof | Journal of Molecular Evolution | en_HK |
dc.rights | The original publication is available at www.springerlink.com | - |
dc.subject | CikA | en_HK |
dc.subject | Constraints | en_HK |
dc.subject | Divergence | en_HK |
dc.subject | GAF | en_HK |
dc.subject | Prokaryotes | en_HK |
dc.title | Circadian input kinases and their homologs in cyanobacteria: Evolutionary constraints versus architectural diversification | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-2844&volume=70&issue=5&spage=453&epage=465&date=2010&atitle=Circadian+input+kinases+and+their+homologs+in+cyanobacteria:+Evolutionary+constraints+versus+architectural+diversification | - |
dc.identifier.email | Dvornyk, V: dvornyk@hku.hk | en_HK |
dc.identifier.authority | Dvornyk, V=rp00693 | en_HK |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1007/s00239-010-9344-0 | en_HK |
dc.identifier.pmid | 20437037 | - |
dc.identifier.scopus | eid_2-s2.0-77954426232 | en_HK |
dc.identifier.hkuros | 170497 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77954426232&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 70 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 453 | en_HK |
dc.identifier.epage | 465 | en_HK |
dc.identifier.isi | WOS:000278094800005 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Baca, I=7005560287 | en_HK |
dc.identifier.scopusauthorid | Sprockett, D=35957248300 | en_HK |
dc.identifier.scopusauthorid | Dvornyk, V=6701789786 | en_HK |
dc.identifier.citeulike | 7163486 | - |
dc.identifier.issnl | 0022-2844 | - |