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Article: Circadian input kinases and their homologs in cyanobacteria: Evolutionary constraints versus architectural diversification

TitleCircadian input kinases and their homologs in cyanobacteria: Evolutionary constraints versus architectural diversification
Authors
KeywordsCikA
Constraints
Divergence
GAF
Prokaryotes
Issue Date2010
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00239
Citation
Journal Of Molecular Evolution, 2010, v. 70 n. 5, p. 453-465 How to Cite?
AbstractThe circadian input kinase A (cikA) gene encodes a protein relaying environmental signal to the central circadian oscillator in cyanobacteria. The CikA protein has a variable architecture and usually consists of four tandemly arrayed domains: GAF, histidine kinase (HisKA), histidine kinase-like ATPase (HATPase-c), and a pseudo-receiver (REC). Among them, HisKA and HATPase-c are the least polymorphic, and REC is not present in heterocystic filamentous cyanobacteria. CikA contains several conserved motifs that are likely important for circadian function. There are at least three types of circadian systems, each of which possesses a different set of circadian genes. The originally described circadian system (kaiABC system) possesses both cikA and kaiA, while the others lack either only cikA (kaiABC Δ) or both (kaiBC). The results we obtained allowed us to approximate the time of the cikA origin to be about 2600-2200 MYA and the time of its loss in the species with the kaiABC Δ or kaiBC system between 1100 and 600 MYA. Circadian specialization of CikA, as opposed to its non-circadian homologs, is a result of several factors, including the unique conserved domain architecture and high evolutionary constraints of some domains and regions, which were previously identified as critical for the circadian function of the gene. © 2010 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/90482
ISSN
2015 Impact Factor: 1.847
2015 SCImago Journal Rankings: 0.952
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

This study was supported by the University of Hong Kong start-up fund for VD.

References

 

DC FieldValueLanguage
dc.contributor.authorBaca, Ien_HK
dc.contributor.authorSprockett, Den_HK
dc.contributor.authorDvornyk, Ven_HK
dc.date.accessioned2010-09-09T01:39:19Z-
dc.date.available2010-09-09T01:39:19Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Molecular Evolution, 2010, v. 70 n. 5, p. 453-465en_HK
dc.identifier.issn0022-2844en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90482-
dc.description.abstractThe circadian input kinase A (cikA) gene encodes a protein relaying environmental signal to the central circadian oscillator in cyanobacteria. The CikA protein has a variable architecture and usually consists of four tandemly arrayed domains: GAF, histidine kinase (HisKA), histidine kinase-like ATPase (HATPase-c), and a pseudo-receiver (REC). Among them, HisKA and HATPase-c are the least polymorphic, and REC is not present in heterocystic filamentous cyanobacteria. CikA contains several conserved motifs that are likely important for circadian function. There are at least three types of circadian systems, each of which possesses a different set of circadian genes. The originally described circadian system (kaiABC system) possesses both cikA and kaiA, while the others lack either only cikA (kaiABC Δ) or both (kaiBC). The results we obtained allowed us to approximate the time of the cikA origin to be about 2600-2200 MYA and the time of its loss in the species with the kaiABC Δ or kaiBC system between 1100 and 600 MYA. Circadian specialization of CikA, as opposed to its non-circadian homologs, is a result of several factors, including the unique conserved domain architecture and high evolutionary constraints of some domains and regions, which were previously identified as critical for the circadian function of the gene. © 2010 Springer Science+Business Media, LLC.en_HK
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00239en_HK
dc.relation.ispartofJournal of Molecular Evolutionen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectCikAen_HK
dc.subjectConstraintsen_HK
dc.subjectDivergenceen_HK
dc.subjectGAFen_HK
dc.subjectProkaryotesen_HK
dc.titleCircadian input kinases and their homologs in cyanobacteria: Evolutionary constraints versus architectural diversificationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-2844&volume=70&issue=5&spage=453&epage=465&date=2010&atitle=Circadian+input+kinases+and+their+homologs+in+cyanobacteria:+Evolutionary+constraints+versus+architectural+diversification-
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_HK
dc.identifier.authorityDvornyk, V=rp00693en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1007/s00239-010-9344-0en_HK
dc.identifier.pmid20437037-
dc.identifier.scopuseid_2-s2.0-77954426232en_HK
dc.identifier.hkuros170497-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954426232&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume70en_HK
dc.identifier.issue5en_HK
dc.identifier.spage453en_HK
dc.identifier.epage465en_HK
dc.identifier.isiWOS:000278094800005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBaca, I=7005560287en_HK
dc.identifier.scopusauthoridSprockett, D=35957248300en_HK
dc.identifier.scopusauthoridDvornyk, V=6701789786en_HK
dc.identifier.citeulike7163486-

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