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Article: Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): Design issues and implications

TitleHeavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): Design issues and implications
Authors
KeywordsClinical multicentre randomized trial
PVR
Retinal detachment
Silicone oil
Issue Date2007
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AOS
Citation
Acta Ophthalmologica Scandinavica, 2007, v. 85 n. 6, p. 623-630 How to Cite?
AbstractPurpose: Proliferative vitreoretinopathy (PVR) is the most important reason for blindness following retinal detachment. Presently, vitreous tamponades such as gas or silicone oil cannot contact the lower part of the retina. A heavier-than-water tamponade displaces the inflammatory and PVR-stimulating environment from the inferior area of the retina. The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO Study) is designed to answer the question of whether a heavier-than-water tamponade improves the prognosis of eyes with PVR of the lower retina. Methods: The HSO Study is a multicentre, randomized, prospective controlled clinical trial comparing two endotamponades within a two-arm parallel group design. Patients with inferiorly and posteriorly located PVR are randomized to either heavy silicone oil or standard silicone oil as a tamponading agent. Three hundred and fifty consecutive patients are recruited per group. After intraoperative re-attachment, patients are randomized to either standard silicone oil (1000 cSt or 5000 cSt) or Densiron® as a tamponading agent. The main endpoint criteria are complete retinal attachment at 12 months and change of visual acuity (VA) 12 months postoperatively compared with the preoperative VA. Secondary endpoints include complete retinal attachment before endotamponade removal, quality of life analysis and the number of retina affecting re-operation within 1 year of follow-up. Results: The design and early recruitment phase of the study are described. Conclusions: The results of this study will uncover whether or not heavy silicone oil improves the prognosis of eyes with PVR. © 2007 Acta Ophthalmol Scand.
Persistent Identifierhttp://hdl.handle.net/10722/90358
ISSN
2007 Impact Factor: 1.848
2011 SCImago Journal Rankings: 0.207
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJoussen, AMen_HK
dc.contributor.authorKirchhof, Ben_HK
dc.contributor.authorSchrage, Nen_HK
dc.contributor.authorOcklenburg, Cen_HK
dc.contributor.authorHilgers, RDen_HK
dc.contributor.authorKirchhof, Ben_HK
dc.contributor.authorJoussen, AMen_HK
dc.contributor.authorHilgers, RDen_HK
dc.contributor.authorOcklenburg, Cen_HK
dc.contributor.authorKirchhof, Ben_HK
dc.contributor.authorHilgers, RDen_HK
dc.contributor.authorLemmen, KDen_HK
dc.contributor.authorJoussen, AMen_HK
dc.contributor.authorHilgers, RDen_HK
dc.contributor.authorOcklenburg, Cen_HK
dc.contributor.authorBartzSchmidt, Uen_HK
dc.contributor.authorBechrakis, Nen_HK
dc.contributor.authorBinder, Sen_HK
dc.contributor.authorBornfeld, Nen_HK
dc.contributor.authorBunse, Aen_HK
dc.contributor.authorCarlsson, JOen_HK
dc.contributor.authorCrafoord, Sen_HK
dc.contributor.authorDahlke, Cen_HK
dc.contributor.authorDithmar, Sen_HK
dc.contributor.authorEngelmann, Ken_HK
dc.contributor.authorEter, Nen_HK
dc.contributor.authorFoerster, MHen_HK
dc.contributor.authorGrisanti, Sen_HK
dc.contributor.authorGroenewald, Cen_HK
dc.contributor.authorHeimann, Hen_HK
dc.contributor.authorHoerauf, Hen_HK
dc.contributor.authorHolz, FGen_HK
dc.contributor.authorKirchhof, Ben_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorLommatzsch, Aen_HK
dc.contributor.authorMackiewicz, Jen_HK
dc.contributor.authorMeireles, Aen_HK
dc.contributor.authorMüller, Men_HK
dc.contributor.authorvan Overdam, Ken_HK
dc.contributor.authorPearce, Ien_HK
dc.contributor.authorPeperkamp, Een_HK
dc.contributor.authorRizzo, Sen_HK
dc.contributor.authorRoider, Jen_HK
dc.contributor.authorSalacz, Gen_HK
dc.contributor.authorSchrage, Nen_HK
dc.contributor.authorSchwartz, Sen_HK
dc.contributor.authorShanks, Gen_HK
dc.contributor.authorStolba, Uen_HK
dc.contributor.authorSzurman, Pen_HK
dc.contributor.authorVeckeneer, Men_HK
dc.contributor.authorWalter, Pen_HK
dc.contributor.authorWiechens, Ben_HK
dc.contributor.authorWong, Den_HK
dc.contributor.authorHöhne, Ken_HK
dc.contributor.authorOttenberg, Den_HK
dc.contributor.authorDomeier, Een_HK
dc.contributor.authorHandzel, Den_HK
dc.contributor.authorKlatt, Cen_HK
dc.contributor.authorPrinz, Ben_HK
dc.contributor.authorLlacer, Hen_HK
dc.contributor.authorJöres, Sen_HK
dc.contributor.authorKusserow, Cen_HK
dc.contributor.authorYörük, Een_HK
dc.contributor.authorJungfermann, Pen_HK
dc.contributor.authorKrömer, Ien_HK
dc.contributor.authorWrede, Jen_HK
dc.contributor.authorHerrmann, Men_HK
dc.contributor.authorVarapi, Gen_HK
dc.contributor.authorGarnett, Len_HK
dc.contributor.authorHebbar, Gen_HK
dc.contributor.authorLipski, Aen_HK
dc.contributor.authorRindsfüser, Men_HK
dc.contributor.authorEriksson, Len_HK
dc.contributor.authorBelting, Cen_HK
dc.date.accessioned2010-09-06T10:09:16Z-
dc.date.available2010-09-06T10:09:16Z-
dc.date.issued2007en_HK
dc.identifier.citationActa Ophthalmologica Scandinavica, 2007, v. 85 n. 6, p. 623-630en_HK
dc.identifier.issn1395-3907en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90358-
dc.description.abstractPurpose: Proliferative vitreoretinopathy (PVR) is the most important reason for blindness following retinal detachment. Presently, vitreous tamponades such as gas or silicone oil cannot contact the lower part of the retina. A heavier-than-water tamponade displaces the inflammatory and PVR-stimulating environment from the inferior area of the retina. The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO Study) is designed to answer the question of whether a heavier-than-water tamponade improves the prognosis of eyes with PVR of the lower retina. Methods: The HSO Study is a multicentre, randomized, prospective controlled clinical trial comparing two endotamponades within a two-arm parallel group design. Patients with inferiorly and posteriorly located PVR are randomized to either heavy silicone oil or standard silicone oil as a tamponading agent. Three hundred and fifty consecutive patients are recruited per group. After intraoperative re-attachment, patients are randomized to either standard silicone oil (1000 cSt or 5000 cSt) or Densiron® as a tamponading agent. The main endpoint criteria are complete retinal attachment at 12 months and change of visual acuity (VA) 12 months postoperatively compared with the preoperative VA. Secondary endpoints include complete retinal attachment before endotamponade removal, quality of life analysis and the number of retina affecting re-operation within 1 year of follow-up. Results: The design and early recruitment phase of the study are described. Conclusions: The results of this study will uncover whether or not heavy silicone oil improves the prognosis of eyes with PVR. © 2007 Acta Ophthalmol Scand.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AOSen_HK
dc.relation.ispartofActa Ophthalmologica Scandinavicaen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectClinical multicentre randomized trialen_HK
dc.subjectPVRen_HK
dc.subjectRetinal detachmenten_HK
dc.subjectSilicone oilen_HK
dc.subject.meshResearch Design-
dc.subject.meshRetinal Detachment - complications - surgery-
dc.subject.meshSilicone Oils - administration and dosage-
dc.subject.meshVitreoretinopathy, Proliferative - etiology - surgery-
dc.subject.meshVitreous Body-
dc.titleHeavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): Design issues and implicationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1395-3907&volume=85&issue=6&spage=623&epage=630&date=2007&atitle=Heavy+silicone+oil+versus+standard+silicone+oil+as+vitreous+tamponade+in+inferior+PVR+(HSO+Study):+design+issues+and+implicationsen_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-0420.2007.00898.xen_HK
dc.identifier.pmid17408389-
dc.identifier.scopuseid_2-s2.0-34548250980en_HK
dc.identifier.hkuros153107en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548250980&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume85en_HK
dc.identifier.issue6en_HK
dc.identifier.spage623en_HK
dc.identifier.epage630en_HK
dc.identifier.isiWOS:000248922800008-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridJoussen, AM=35080476300en_HK
dc.identifier.scopusauthoridKirchhof, B=7006285825en_HK
dc.identifier.scopusauthoridSchrage, N=7004065696en_HK
dc.identifier.scopusauthoridOcklenburg, C=26436098000en_HK
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dc.identifier.scopusauthoridHilgers, RD=35080344800en_HK
dc.identifier.scopusauthoridLemmen, KD=6701478365en_HK
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dc.identifier.scopusauthoridBinder, S=35458330400en_HK
dc.identifier.scopusauthoridBornfeld, N=7005816045en_HK
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dc.identifier.scopusauthoridGrisanti, S=7004580871en_HK
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dc.identifier.citeulike1587677-

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