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Article: Histological findings of a choroidal neovascular membrane removed at the time of macular translocation in a patient previously treated with intravitreal bevacizumab treatment (Avastin)

TitleHistological findings of a choroidal neovascular membrane removed at the time of macular translocation in a patient previously treated with intravitreal bevacizumab treatment (Avastin)
Authors
Issue Date2007
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal Of Ophthalmology, 2007, v. 91 n. 5, p. 602-604 How to Cite?
AbstractAim: To report the findings in a patient treated by repeated intravitreal bevacizumab (Avastin) injections, followed by macular relocation and excision of subfoveal choroidal neovascular membrane (CNV). Methods: Histopathological evaluation of the CNV specimen, including immunohistochemical assessment. Results: During surgical excision, the CNV seemed to be avascular and its underlying bed did not bleed. Histopathological examination revealed that the CNV comprised avascular fibrous subretinal tissue containing fibroblastic retinal pigment epithelial (RPE) cells, fragments of irregular thickened Bruch's membrane and fibrotic choroidal tissue containing some medium-sized vessels but no choriocapillaris. Conclusions: The development of an RPE tear during the course of Avastin treatment may reflect contraction of the avascular subretinal tissue, whereas the lack of capillaries in both choroidal and subretinal components may be caused by the increased access of Avastin to the choriocapillaris in the presence of the RPE tear.
Persistent Identifierhttp://hdl.handle.net/10722/90351
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.873
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGibran, SKen_HK
dc.contributor.authorSachdev, Aen_HK
dc.contributor.authorStappler, Ten_HK
dc.contributor.authorNewsome, Ren_HK
dc.contributor.authorWong, Den_HK
dc.contributor.authorHiscott, Pen_HK
dc.date.accessioned2010-09-06T10:09:11Z-
dc.date.available2010-09-06T10:09:11Z-
dc.date.issued2007en_HK
dc.identifier.citationBritish Journal Of Ophthalmology, 2007, v. 91 n. 5, p. 602-604en_HK
dc.identifier.issn0007-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90351-
dc.description.abstractAim: To report the findings in a patient treated by repeated intravitreal bevacizumab (Avastin) injections, followed by macular relocation and excision of subfoveal choroidal neovascular membrane (CNV). Methods: Histopathological evaluation of the CNV specimen, including immunohistochemical assessment. Results: During surgical excision, the CNV seemed to be avascular and its underlying bed did not bleed. Histopathological examination revealed that the CNV comprised avascular fibrous subretinal tissue containing fibroblastic retinal pigment epithelial (RPE) cells, fragments of irregular thickened Bruch's membrane and fibrotic choroidal tissue containing some medium-sized vessels but no choriocapillaris. Conclusions: The development of an RPE tear during the course of Avastin treatment may reflect contraction of the avascular subretinal tissue, whereas the lack of capillaries in both choroidal and subretinal components may be caused by the increased access of Avastin to the choriocapillaris in the presence of the RPE tear.en_HK
dc.languageengen_HK
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/en_HK
dc.relation.ispartofBritish Journal of Ophthalmologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsBritish Journal of Ophthalmology. Copyright © BMJ Publishing Group.en_HK
dc.subject.meshAngiogenesis Inhibitors - administration and dosage-
dc.subject.meshAntibodies, Monoclonal - administration and dosage-
dc.subject.meshChoroidal Neovascularization - drug therapy - pathology - surgery-
dc.subject.meshDrug Administration Routes-
dc.subject.meshMacular Degeneration - drug therapy - pathology - surgery-
dc.titleHistological findings of a choroidal neovascular membrane removed at the time of macular translocation in a patient previously treated with intravitreal bevacizumab treatment (Avastin)en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1161&volume=91&issue=5&spage=602&epage=604&date=2007&atitle=Histological+findings+of+a+choroidal+neovascular+membrane+removed+at+the+time+of+macular+translocation+in+a+patient+previously+treated+with+intravitreal+bevacizumab+treatment+(Avastin)en_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1136/bjo.2006.108795en_HK
dc.identifier.pmid17166893-
dc.identifier.pmcidPMC1954763-
dc.identifier.scopuseid_2-s2.0-34247271808en_HK
dc.identifier.hkuros136228en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247271808&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume91en_HK
dc.identifier.issue5en_HK
dc.identifier.spage602en_HK
dc.identifier.epage604en_HK
dc.identifier.isiWOS:000245829900014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridGibran, SK=13205333800en_HK
dc.identifier.scopusauthoridSachdev, A=24079178400en_HK
dc.identifier.scopusauthoridStappler, T=8563727800en_HK
dc.identifier.scopusauthoridNewsome, R=16304944600en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK
dc.identifier.scopusauthoridHiscott, P=7006368693en_HK

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