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Article: Progression of myopia and high myopia in the early treatment for retinopathy of prematurity study: findings to 3 years of age

TitleProgression of myopia and high myopia in the early treatment for retinopathy of prematurity study: findings to 3 years of age
Authors
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophtha
Citation
Ophthalmology, 2008, v. 115 n. 6, p. 1058-1064.e1 How to Cite?
AbstractPURPOSE: Examine the prevalence of myopia and high myopia, at 6 and 9 months postterm and 2 and 3 years postnatal in preterm children with birth weights < 1251 g who developed high-risk prethreshold retinopathy of prematurity (ROP) in the neonatal period and participated in the Early Treatment for ROP Study. DESIGN: Randomized controlled clinical trial. PARTICIPANTS: Four hundred one infants who developed prethreshold ROP and were determined to have a significant risk (>/=15%) of poor structural outcomes without treatment. Children underwent cycloplegic retinoscopy at examinations between 6 months postterm and 3 years' postnatal age. INTERVENTION: Eyes were randomized to receive treatment at high-risk prethreshold ROP (early treated [ET]) or conventional management (CM), with treatment only if threshold ROP developed. MAIN OUTCOME MEASURES: Myopia (spherical equivalent >/= 0.25 diopters [D]) or high myopia (>/=5.00 D) at each visit. RESULTS: Prevalences of myopia were similar in treated eyes in the ET and CM groups, increasing from approximately 58% to 68% between 6 and 9 months, with little change thereafter. Both ET and CM eyes showed an increasing prevalence of high myopia, approximately 19% at 6 months and increasing 4% to 8% at successive examinations. Zone of ROP and presence or absence of plus disease had little effect on prevalence of myopia or high myopia between ages 6 months and 3 years. However, eyes with ROP residua (straightened temporal vessels or macular heterotopia) showed a higher prevalence of myopia and high myopia than eyes without residua. CONCLUSIONS: Approximately 70% of high-risk prethreshold ROP eyes were myopic in early childhood, and the proportion with high myopia increased steadily between ages 6 months and 3 years. Timing of treatment of high-risk prethreshold ROP did not influence refractive error development. There was little difference in prevalence of myopia or high myopia between eyes with zone I and eyes with zone II ROP, nor between eyes with plus disease and eyes with no plus disease. However, prevalence of myopia and high myopia was higher in eyes with retinal residua of ROP than in eyes with normal-appearing posterior poles, highlighting the importance of follow-up eye examinations of infants who had prethreshold ROP.
Persistent Identifierhttp://hdl.handle.net/10722/90350
ISSN
2015 Impact Factor: 6.75
2015 SCImago Journal Rankings: 4.745
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorQuinn, GEen_HK
dc.contributor.authorDobson, Ven_HK
dc.contributor.authorDavitt, BV-
dc.contributor.authorHardy, RJ-
dc.contributor.authorTung, B-
dc.contributor.authorPedroza, C-
dc.contributor.authorGood, WV-
dc.contributor.authorEarly Treatment for Retinopathy of Prematurity Cooperative Group-
dc.contributor.authorLai, WW-
dc.date.accessioned2010-09-06T10:09:10Z-
dc.date.available2010-09-06T10:09:10Z-
dc.date.issued2008en_HK
dc.identifier.citationOphthalmology, 2008, v. 115 n. 6, p. 1058-1064.e1en_HK
dc.identifier.issn0161-6420en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90350-
dc.description.abstractPURPOSE: Examine the prevalence of myopia and high myopia, at 6 and 9 months postterm and 2 and 3 years postnatal in preterm children with birth weights < 1251 g who developed high-risk prethreshold retinopathy of prematurity (ROP) in the neonatal period and participated in the Early Treatment for ROP Study. DESIGN: Randomized controlled clinical trial. PARTICIPANTS: Four hundred one infants who developed prethreshold ROP and were determined to have a significant risk (>/=15%) of poor structural outcomes without treatment. Children underwent cycloplegic retinoscopy at examinations between 6 months postterm and 3 years' postnatal age. INTERVENTION: Eyes were randomized to receive treatment at high-risk prethreshold ROP (early treated [ET]) or conventional management (CM), with treatment only if threshold ROP developed. MAIN OUTCOME MEASURES: Myopia (spherical equivalent >/= 0.25 diopters [D]) or high myopia (>/=5.00 D) at each visit. RESULTS: Prevalences of myopia were similar in treated eyes in the ET and CM groups, increasing from approximately 58% to 68% between 6 and 9 months, with little change thereafter. Both ET and CM eyes showed an increasing prevalence of high myopia, approximately 19% at 6 months and increasing 4% to 8% at successive examinations. Zone of ROP and presence or absence of plus disease had little effect on prevalence of myopia or high myopia between ages 6 months and 3 years. However, eyes with ROP residua (straightened temporal vessels or macular heterotopia) showed a higher prevalence of myopia and high myopia than eyes without residua. CONCLUSIONS: Approximately 70% of high-risk prethreshold ROP eyes were myopic in early childhood, and the proportion with high myopia increased steadily between ages 6 months and 3 years. Timing of treatment of high-risk prethreshold ROP did not influence refractive error development. There was little difference in prevalence of myopia or high myopia between eyes with zone I and eyes with zone II ROP, nor between eyes with plus disease and eyes with no plus disease. However, prevalence of myopia and high myopia was higher in eyes with retinal residua of ROP than in eyes with normal-appearing posterior poles, highlighting the importance of follow-up eye examinations of infants who had prethreshold ROP.-
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophthaen_HK
dc.relation.ispartofOphthalmologyen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in <Journal title>. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI#en_HK
dc.subject.meshChild, Preschool-
dc.subject.meshDisease Progression-
dc.subject.meshMyopia - epidemiology - physiopathology-
dc.subject.meshMyopia, Degenerative - epidemiology - physiopathology-
dc.subject.meshRetinopathy of Prematurity - epidemiology - physiopathology - therapy-
dc.titleProgression of myopia and high myopia in the early treatment for retinopathy of prematurity study: findings to 3 years of ageen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0161-6420&volume=115&spage=1058&epage=1064.e1&date=2008&atitle=Early+Treatment+for+Retinopathy+of+Prematurity+Cooperative+Group.+Progression+of+myopia+and+high+myopia+in+the+early+treatment+for+retinopathy+of+prematurity+study:+findings+to+3+years+of+age.+en_HK
dc.identifier.emailLai, WWK: wicolai@hku.hken_HK
dc.identifier.authorityLai, WWK=rp00531en_HK
dc.identifier.doi10.1016/j.ophtha.2007.07.028-
dc.identifier.pmid18423871-
dc.identifier.scopuseid_2-s2.0-44449104913-
dc.identifier.hkuros144390en_HK
dc.identifier.volume115-
dc.identifier.issue6-
dc.identifier.spage1058-
dc.identifier.epage1064.e1-
dc.identifier.isiWOS:000256282800021-
dc.publisher.placeUnited States-

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