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Article: Functional and morphometric brain dissociation between dyslexia and reading ability

TitleFunctional and morphometric brain dissociation between dyslexia and reading ability
Authors
KeywordsCompensation
Functional MRI
Inferior frontal region
Inferior parietal lobule
Voxel-based morphometry
Issue Date2007
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2007, v. 104 n. 10, p. 4234-4239 How to Cite?
AbstractIn functional neuroimaging studies, individuals with dyslexia frequently exhibit both hypoactivation, often in the left parietotemporal cortex, and hyperactivation, often in the left inferior frontal cortex, but there has been no evidence to suggest how to interpret the differential relations of hypoactivation and hyperactivation to dyslexia. To address this question, we measured brain activation by functional MRI during visual word rhyme judgment compared with visual cross-hair fixation rest, and we measured gray matter morphology by voxel-based morphometry in dyslexic adolescents in comparison with (i) an age-matched group, and (ii) a reading-matched group younger than the dyslexic group but equal to the dyslexic group in reading performance. Relative to the age-matched group (n = 19; mean 14.4 years), the dyslexic group (n = 19; mean 14.4 years) exhibited hypoactivation in left parietal and bilateral fusiform cortices and hyperactivation in left inferior and middle frontal gyri, caudate, and thalamus. Relative to the reading-matched group (n = 12; mean 9.8 years), the dyslexic group (n = 12; mean 14.5 years) also exhibited hypoactivation in left parietal and fusiform regions but equal activation in all four areas that had exhibited hyperactivation relative to age-matched controls as well. In regions that exhibited atypical activation in the dyslexic group, only the left parietal region exhibited reduced gray matter volume relative to both control groups. Thus, areas of hyperactivation in dyslexia reflected processes related to the level of current reading ability independent of dyslexia. In contrast, areas of hypoactivation in dyslexia reflected functional atypicalities related to dyslexia itself, independent of current reading ability, and related to atypical brain morphology in dyslexia. © 2007 by The National Academy of Sciences of the USA.
Persistent Identifierhttp://hdl.handle.net/10722/90299
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHoeft, Fen_HK
dc.contributor.authorMeyler, Aen_HK
dc.contributor.authorHernandez, Aen_HK
dc.contributor.authorJuel, Cen_HK
dc.contributor.authorTaylorHill, Hen_HK
dc.contributor.authorMartindale, JLen_HK
dc.contributor.authorMcMillon, Gen_HK
dc.contributor.authorKolchugina, Gen_HK
dc.contributor.authorBlack, JMen_HK
dc.contributor.authorFaizi, Aen_HK
dc.contributor.authorDeutsch, GKen_HK
dc.contributor.authorWai, TSen_HK
dc.contributor.authorReiss, ALen_HK
dc.contributor.authorWhitfieldGabrieli, Sen_HK
dc.contributor.authorGabrieli, JDEen_HK
dc.date.accessioned2010-09-06T10:08:23Z-
dc.date.available2010-09-06T10:08:23Z-
dc.date.issued2007en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2007, v. 104 n. 10, p. 4234-4239en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90299-
dc.description.abstractIn functional neuroimaging studies, individuals with dyslexia frequently exhibit both hypoactivation, often in the left parietotemporal cortex, and hyperactivation, often in the left inferior frontal cortex, but there has been no evidence to suggest how to interpret the differential relations of hypoactivation and hyperactivation to dyslexia. To address this question, we measured brain activation by functional MRI during visual word rhyme judgment compared with visual cross-hair fixation rest, and we measured gray matter morphology by voxel-based morphometry in dyslexic adolescents in comparison with (i) an age-matched group, and (ii) a reading-matched group younger than the dyslexic group but equal to the dyslexic group in reading performance. Relative to the age-matched group (n = 19; mean 14.4 years), the dyslexic group (n = 19; mean 14.4 years) exhibited hypoactivation in left parietal and bilateral fusiform cortices and hyperactivation in left inferior and middle frontal gyri, caudate, and thalamus. Relative to the reading-matched group (n = 12; mean 9.8 years), the dyslexic group (n = 12; mean 14.5 years) also exhibited hypoactivation in left parietal and fusiform regions but equal activation in all four areas that had exhibited hyperactivation relative to age-matched controls as well. In regions that exhibited atypical activation in the dyslexic group, only the left parietal region exhibited reduced gray matter volume relative to both control groups. Thus, areas of hyperactivation in dyslexia reflected processes related to the level of current reading ability independent of dyslexia. In contrast, areas of hypoactivation in dyslexia reflected functional atypicalities related to dyslexia itself, independent of current reading ability, and related to atypical brain morphology in dyslexia. © 2007 by The National Academy of Sciences of the USA.en_HK
dc.languageengen_HK
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.subjectCompensationen_HK
dc.subjectFunctional MRIen_HK
dc.subjectInferior frontal regionen_HK
dc.subjectInferior parietal lobuleen_HK
dc.subjectVoxel-based morphometryen_HK
dc.titleFunctional and morphometric brain dissociation between dyslexia and reading abilityen_HK
dc.typeArticleen_HK
dc.identifier.emailWai, TS: siok@hkucc.hku.hken_HK
dc.identifier.authorityWai, TS=rp01208en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1073/pnas.0609399104en_HK
dc.identifier.pmid17360506-
dc.identifier.scopuseid_2-s2.0-34247205760en_HK
dc.identifier.hkuros128536en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247205760&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume104en_HK
dc.identifier.issue10en_HK
dc.identifier.spage4234en_HK
dc.identifier.epage4239en_HK
dc.identifier.isiWOS:000244972400100-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHoeft, F=15061514800en_HK
dc.identifier.scopusauthoridMeyler, A=8588987100en_HK
dc.identifier.scopusauthoridHernandez, A=15061550000en_HK
dc.identifier.scopusauthoridJuel, C=35868491900en_HK
dc.identifier.scopusauthoridTaylorHill, H=15062186700en_HK
dc.identifier.scopusauthoridMartindale, JL=36779565900en_HK
dc.identifier.scopusauthoridMcMillon, G=15061396800en_HK
dc.identifier.scopusauthoridKolchugina, G=16233776800en_HK
dc.identifier.scopusauthoridBlack, JM=16232411900en_HK
dc.identifier.scopusauthoridFaizi, A=16233224300en_HK
dc.identifier.scopusauthoridDeutsch, GK=7006704228en_HK
dc.identifier.scopusauthoridWai, TS=6602471035en_HK
dc.identifier.scopusauthoridReiss, AL=7102359271en_HK
dc.identifier.scopusauthoridWhitfieldGabrieli, S=8910908400en_HK
dc.identifier.scopusauthoridGabrieli, JDE=7004907306en_HK
dc.identifier.citeulike1206264-

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