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Article: A structural-functional basis for dyslexia in the cortex of Chinese readers

TitleA structural-functional basis for dyslexia in the cortex of Chinese readers
Authors
KeywordsBrain function
Chinese language
Culture
Neuroimaging
Reading disorder
Issue Date2008
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2008, v. 105 n. 14, p. 5561-5566 How to Cite?
AbstractDevelopmental dyslexia is a neurobiologically based disorder that affects ≈5-17% of school children and is characterized by a severe impairment in reading skill acquisition. For readers of alphabetic (e.g., English) languages, recent neuroimaging studies have demonstrated that dyslexia is associated with weak reading-related activity in left temporoparietal and occipitotemporal regions, and this activity difference may reflect reductions in gray matter volume in these areas. Here, we find different structural and functional abnormalities in dyslexic readers of Chinese, a non-alphabetic language. Compared with normally developing controls, children with impaired reading in logographic Chinese exhibited reduced gray matter volume in a left middle frontal gyrus region previously shown to be important for Chinese reading and writing. Using functional MRI to study language-related activation of cortical regions in dyslexics, we found reduced activation in this same left middle frontal gyrus region in Chinese dyslexics versus controls, and there was a significant correlation between gray matter volume and activation in the language task in this same area. By contrast, Chinese dyslexics did not show functional or structural (i.e., volumetric gray matter) differences from normal subjects in the more posterior brain systems that have been shown to be abnormal in alphabetic-language dyslexics. The results suggest that the structural and functional basis for dyslexia varies between alphabetic and nonalphabetic languages. © 2008 by The National Academy of Sciences of the USA.
Persistent Identifierhttp://hdl.handle.net/10722/90283
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWai, TSen_HK
dc.contributor.authorNiu, Zen_HK
dc.contributor.authorJin, Zen_HK
dc.contributor.authorPerfetti, CAen_HK
dc.contributor.authorLi, HTen_HK
dc.date.accessioned2010-09-06T10:08:11Z-
dc.date.available2010-09-06T10:08:11Z-
dc.date.issued2008en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2008, v. 105 n. 14, p. 5561-5566en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90283-
dc.description.abstractDevelopmental dyslexia is a neurobiologically based disorder that affects ≈5-17% of school children and is characterized by a severe impairment in reading skill acquisition. For readers of alphabetic (e.g., English) languages, recent neuroimaging studies have demonstrated that dyslexia is associated with weak reading-related activity in left temporoparietal and occipitotemporal regions, and this activity difference may reflect reductions in gray matter volume in these areas. Here, we find different structural and functional abnormalities in dyslexic readers of Chinese, a non-alphabetic language. Compared with normally developing controls, children with impaired reading in logographic Chinese exhibited reduced gray matter volume in a left middle frontal gyrus region previously shown to be important for Chinese reading and writing. Using functional MRI to study language-related activation of cortical regions in dyslexics, we found reduced activation in this same left middle frontal gyrus region in Chinese dyslexics versus controls, and there was a significant correlation between gray matter volume and activation in the language task in this same area. By contrast, Chinese dyslexics did not show functional or structural (i.e., volumetric gray matter) differences from normal subjects in the more posterior brain systems that have been shown to be abnormal in alphabetic-language dyslexics. The results suggest that the structural and functional basis for dyslexia varies between alphabetic and nonalphabetic languages. © 2008 by The National Academy of Sciences of the USA.en_HK
dc.languageengen_HK
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.subjectBrain functionen_HK
dc.subjectChinese languageen_HK
dc.subjectCultureen_HK
dc.subjectNeuroimagingen_HK
dc.subjectReading disorderen_HK
dc.titleA structural-functional basis for dyslexia in the cortex of Chinese readersen_HK
dc.typeArticleen_HK
dc.identifier.emailWai, TS: siok@hkucc.hku.hken_HK
dc.identifier.authorityWai, TS=rp01208en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1073/pnas.0801750105en_HK
dc.identifier.pmid18391194-
dc.identifier.scopuseid_2-s2.0-44449161302en_HK
dc.identifier.hkuros141907en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44449161302&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume105en_HK
dc.identifier.issue14en_HK
dc.identifier.spage5561en_HK
dc.identifier.epage5566en_HK
dc.identifier.isiWOS:000254893600050-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWai, TS=6602471035en_HK
dc.identifier.scopusauthoridNiu, Z=23393033800en_HK
dc.identifier.scopusauthoridJin, Z=46961272300en_HK
dc.identifier.scopusauthoridPerfetti, CA=7005318729en_HK
dc.identifier.scopusauthoridLi, HT=24329900400en_HK
dc.identifier.citeulike2642006-

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