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Article: A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with Schizophrenia

TitleA randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with Schizophrenia
Authors
Issue Date2008
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychopharmacology.com
Citation
Journal Of Clinical Psychopharmacology, 2008, v. 28 n. 3, p. 264-270 How to Cite?
AbstractHyperprolactinemia is a common adverse effect that occurs as a result of antipsychotic therapies, which often results in discontinuation. Empirical evidence has shown that some herbal medicines have suppressive effects on prolactin (PRL) hyperactivities. This study was designed to compare the herbal preparation called Peony-Glycyrrhiza Decoction (PGD) with bromocriptine (BMT), a dopamine agonist widely used for PRL-secreting disorders, in the treatment of risperidone-induced hyperprolactinemia. Twenty schizophrenic women who were under risperidone maintenance treatment, diagnosed with hyperprolactinemia (serum PRL levels >50 μg/L), and currently experiencing ligomenorrhea or amenorrhea were selected for the study. Subjects were randomized to additional treatment with PGD (45 g/d) followed by BMT (5 mg/d) or BMT followed by PGD at the same doses for 4 weeks each, with an interval of 4-week washout period between 2 treatment sessions. The severity of psychotic symptoms, adverse events, serum PRL, estradiol, testosterone, and progesterone levels were examined at baseline and end point. Peony-Glycyrrhiza Decoction treatment produced a significant baseline-end point decrease in serum PRL levels, without exacerbating psychosis and changing other hormones, and the decreased amplitudes were similar to those of BMT (24% vs 21%-28%). Moreover, there was a significantly greater proportion of patients during PGD treatment than BMT treatment showing improvements on adverse effects associated with hyperprolactinemia (56% vs 17%, P = 0.037). These results suggest that the herbal therapy can yield additional benefits while having comparable efficacy in treating antipsychotic-induced hyperprolactinemia in individuals with schizophrenia. © 2008 by Lippincott Williams and Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/89667
ISSN
2015 Impact Factor: 3.0
2015 SCImago Journal Rankings: 1.091
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuan, HNen_HK
dc.contributor.authorWang, CYen_HK
dc.contributor.authorSze, CWen_HK
dc.contributor.authorTong, Yen_HK
dc.contributor.authorTan, QRen_HK
dc.contributor.authorFeng, XJen_HK
dc.contributor.authorLiu, RMen_HK
dc.contributor.authorZhang, JZen_HK
dc.contributor.authorZhang, YBen_HK
dc.contributor.authorZhang, ZJen_HK
dc.date.accessioned2010-09-06T10:00:10Z-
dc.date.available2010-09-06T10:00:10Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Clinical Psychopharmacology, 2008, v. 28 n. 3, p. 264-270en_HK
dc.identifier.issn0271-0749en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89667-
dc.description.abstractHyperprolactinemia is a common adverse effect that occurs as a result of antipsychotic therapies, which often results in discontinuation. Empirical evidence has shown that some herbal medicines have suppressive effects on prolactin (PRL) hyperactivities. This study was designed to compare the herbal preparation called Peony-Glycyrrhiza Decoction (PGD) with bromocriptine (BMT), a dopamine agonist widely used for PRL-secreting disorders, in the treatment of risperidone-induced hyperprolactinemia. Twenty schizophrenic women who were under risperidone maintenance treatment, diagnosed with hyperprolactinemia (serum PRL levels >50 μg/L), and currently experiencing ligomenorrhea or amenorrhea were selected for the study. Subjects were randomized to additional treatment with PGD (45 g/d) followed by BMT (5 mg/d) or BMT followed by PGD at the same doses for 4 weeks each, with an interval of 4-week washout period between 2 treatment sessions. The severity of psychotic symptoms, adverse events, serum PRL, estradiol, testosterone, and progesterone levels were examined at baseline and end point. Peony-Glycyrrhiza Decoction treatment produced a significant baseline-end point decrease in serum PRL levels, without exacerbating psychosis and changing other hormones, and the decreased amplitudes were similar to those of BMT (24% vs 21%-28%). Moreover, there was a significantly greater proportion of patients during PGD treatment than BMT treatment showing improvements on adverse effects associated with hyperprolactinemia (56% vs 17%, P = 0.037). These results suggest that the herbal therapy can yield additional benefits while having comparable efficacy in treating antipsychotic-induced hyperprolactinemia in individuals with schizophrenia. © 2008 by Lippincott Williams and Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychopharmacology.comen_HK
dc.relation.ispartofJournal of Clinical Psychopharmacologyen_HK
dc.rightsJournal of Clinical Psychopharmacology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.titleA randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with Schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0271-0749&volume=28&spage=264&epage=370.&date=2008&atitle=A+Randomized+Crossover+Comparison+of+Herbal+Medicine+and+Bromocriptine+against+Risperidone-Induced+Hyperprolactinemia+in+Patients+with+Schizophreniaen_HK
dc.identifier.emailSze, CW: stephens@hku.hken_HK
dc.identifier.emailTong, Y: tongyao@hku.hken_HK
dc.identifier.emailZhang, YB: ybzhang@hku.hken_HK
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_HK
dc.identifier.authoritySze, CW=rp00514en_HK
dc.identifier.authorityTong, Y=rp00509en_HK
dc.identifier.authorityZhang, YB=rp01410en_HK
dc.identifier.authorityZhang, ZJ=rp01297en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/JCP.0b013e318172473cen_HK
dc.identifier.scopuseid_2-s2.0-51449084310en_HK
dc.identifier.hkuros145999en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-51449084310&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue3en_HK
dc.identifier.spage264en_HK
dc.identifier.epage270en_HK
dc.identifier.isiWOS:000255914000002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuan, HN=15770413900en_HK
dc.identifier.scopusauthoridWang, CY=35345843000en_HK
dc.identifier.scopusauthoridSze, CW=23482617000en_HK
dc.identifier.scopusauthoridTong, Y=9045384000en_HK
dc.identifier.scopusauthoridTan, QR=7102120177en_HK
dc.identifier.scopusauthoridFeng, XJ=24778135600en_HK
dc.identifier.scopusauthoridLiu, RM=7404552293en_HK
dc.identifier.scopusauthoridZhang, JZ=7601357395en_HK
dc.identifier.scopusauthoridZhang, YB=23483121900en_HK
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_HK
dc.identifier.citeulike7218880-

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