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Article: Characterization of chemical components in extracts from Si-wu decoction with proliferation-promoting effects on rat mesenchymal stem cells

TitleCharacterization of chemical components in extracts from Si-wu decoction with proliferation-promoting effects on rat mesenchymal stem cells
Authors
KeywordsChemical components
Proliferation of rat mesenchymal stem cells (MSCs)
Si-wu decoction
Traditional chinese medicine
Issue Date2008
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/bmc
Citation
Bioorganic And Medicinal Chemistry, 2008, v. 16 n. 9, p. 5109-5114 How to Cite?
AbstractSi-wu decoction (SDE), a classic prescription in Traditional Chinese Medicine, has been used for the treatment of a variety of anaemia in China for centuries. In order to explore the scientific basis of the formula, we investigated the relationship between its chemical components and proliferation-promoting effects on rat marrow-derived mesenchymal stem cells (MSCs). Twenty (F-1-F-20) components were obtained and their proliferation-promoting effects on MSCs were investigated. The results showed that F-4, F-7, F-10, and F-11 stimulated the proliferation of the MSCs. The chemical components with proliferation-promoting effects on the MSCs were further identified by GC-MS, HPLC, LC-MS, and other spectra. Ligustilide (F-4) isolated from SDE showed the best proliferation-promoting effect. Palmitic acid methyl ester and stearic acid ethyl identified from F-7 and F-10 by HPLC were also confirmed to be responsible for stimulating MSC proliferation. A novel compound, 6,7-dihydroxy-3-(-prop-1-enyl)isobenzofuran-1(3H)-one, was found in the SDE for the first time by LC-MS n, whose structure was similar to ligustilide. © 2008 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89662
ISSN
2015 Impact Factor: 2.923
2015 SCImago Journal Rankings: 1.064
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZeng, HPen_HK
dc.contributor.authorWang, TTen_HK
dc.contributor.authorChen, Wen_HK
dc.contributor.authorWang, CYen_HK
dc.contributor.authorChen, DFen_HK
dc.contributor.authorShen, JGen_HK
dc.date.accessioned2010-09-06T10:00:05Z-
dc.date.available2010-09-06T10:00:05Z-
dc.date.issued2008en_HK
dc.identifier.citationBioorganic And Medicinal Chemistry, 2008, v. 16 n. 9, p. 5109-5114en_HK
dc.identifier.issn0968-0896en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89662-
dc.description.abstractSi-wu decoction (SDE), a classic prescription in Traditional Chinese Medicine, has been used for the treatment of a variety of anaemia in China for centuries. In order to explore the scientific basis of the formula, we investigated the relationship between its chemical components and proliferation-promoting effects on rat marrow-derived mesenchymal stem cells (MSCs). Twenty (F-1-F-20) components were obtained and their proliferation-promoting effects on MSCs were investigated. The results showed that F-4, F-7, F-10, and F-11 stimulated the proliferation of the MSCs. The chemical components with proliferation-promoting effects on the MSCs were further identified by GC-MS, HPLC, LC-MS, and other spectra. Ligustilide (F-4) isolated from SDE showed the best proliferation-promoting effect. Palmitic acid methyl ester and stearic acid ethyl identified from F-7 and F-10 by HPLC were also confirmed to be responsible for stimulating MSC proliferation. A novel compound, 6,7-dihydroxy-3-(-prop-1-enyl)isobenzofuran-1(3H)-one, was found in the SDE for the first time by LC-MS n, whose structure was similar to ligustilide. © 2008 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/bmcen_HK
dc.relation.ispartofBioorganic and Medicinal Chemistryen_HK
dc.subjectChemical componentsen_HK
dc.subjectProliferation of rat mesenchymal stem cells (MSCs)en_HK
dc.subjectSi-wu decoctionen_HK
dc.subjectTraditional chinese medicineen_HK
dc.titleCharacterization of chemical components in extracts from Si-wu decoction with proliferation-promoting effects on rat mesenchymal stem cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0968-0896&volume=16&issue=9&spage=5109&epage=5114&date=2008&atitle=Characterization+of+chemical+components+in+extracts+from+Si-wu+decoction+with+proliferation-promoting+effects+on+rat+mesenchymal+stem+cells.en_HK
dc.identifier.emailShen, JG: shenjg@hku.hken_HK
dc.identifier.authorityShen, JG=rp00487en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bmc.2008.03.024en_HK
dc.identifier.pmid18374577en_HK
dc.identifier.scopuseid_2-s2.0-43049121347en_HK
dc.identifier.hkuros142040en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-43049121347&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue9en_HK
dc.identifier.spage5109en_HK
dc.identifier.epage5114en_HK
dc.identifier.isiWOS:000255605600028-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZeng, HP=7401472015en_HK
dc.identifier.scopusauthoridWang, TT=8834035200en_HK
dc.identifier.scopusauthoridChen, W=36012682000en_HK
dc.identifier.scopusauthoridWang, CY=8208296700en_HK
dc.identifier.scopusauthoridChen, DF=26027705500en_HK
dc.identifier.scopusauthoridShen, JG=7404929947en_HK

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