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Article: Synthesis and evaluation of novel substituted 5-hydroxycoumarin and pyranocoumarin derivatives exhibiting significant antiproliferative activity against breast cancer cell lines

TitleSynthesis and evaluation of novel substituted 5-hydroxycoumarin and pyranocoumarin derivatives exhibiting significant antiproliferative activity against breast cancer cell lines
Authors
Mao, WwWang, TtZeng, HpWang, ZyChen, JpShen, Jg
KeywordsAgainst breast cancer cell lines
Antiproliferative activity
Breast cancer
Hydroxycoumarin
New substituted 5-hydroxycoumarin
Pyranocoumarin
Issue Date2009
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/bmcl
Citation
Bioorganic And Medicinal Chemistry Letters, 2009, v. 19 n. 16, p. 4570-4573 How to Cite?
DOI: http://dx.doi.org/10.1016/j.bmcl.2009.06.098
AbstractA library of novel 5-hydroxycoumarin and pyranocoumarin derivatives was constructed via silica sulfuric acid-catalyzed pechmann reaction and Pd(0)-catalyzed suzuki coupling in tandem, and their antiproliferative activities against breast cancer cells MCF-7 and MDA-MB-231 were evaluated. The results showed that compounds such as 6b, 6d, 6h, and 6k possess significant antiproliferative activity against MCF-7 cell line with the IC 50 values of 7.2, 5.3, 3.3, and 6.5 μM, respectively. © 2009 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89636
ISSN
0960-894X
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.508
ISI Accession Number ID
WOS:000268358800009
Funding AgencyGrant Number
National Natural Science Foundation of China20671036
2007A010500008
2008B010800030
Funding Information:

Financial support from the National Natural Science Foundation of China (Nos. 20671036, 2007A010500008, and 2008B010800030) is gratefully acknowledged.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorMao, Wwen_HK
dc.contributor.authorWang, Tten_HK
dc.contributor.authorZeng, Hpen_HK
dc.contributor.authorWang, Zyen_HK
dc.contributor.authorChen, Jpen_HK
dc.contributor.authorShen, Jgen_HK
dc.date.accessioned2010-09-06T09:59:43Z-
dc.date.available2010-09-06T09:59:43Z-
dc.date.issued2009en_HK
dc.identifier.citationBioorganic And Medicinal Chemistry Letters, 2009, v. 19 n. 16, p. 4570-4573en_HK
dc.identifier.issn0960-894Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/89636-
dc.description.abstractA library of novel 5-hydroxycoumarin and pyranocoumarin derivatives was constructed via silica sulfuric acid-catalyzed pechmann reaction and Pd(0)-catalyzed suzuki coupling in tandem, and their antiproliferative activities against breast cancer cells MCF-7 and MDA-MB-231 were evaluated. The results showed that compounds such as 6b, 6d, 6h, and 6k possess significant antiproliferative activity against MCF-7 cell line with the IC 50 values of 7.2, 5.3, 3.3, and 6.5 μM, respectively. © 2009 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/bmclen_HK
dc.relation.ispartofBioorganic and Medicinal Chemistry Lettersen_HK
dc.subjectAgainst breast cancer cell linesen_HK
dc.subjectAntiproliferative activityen_HK
dc.subjectBreast canceren_HK
dc.subjectHydroxycoumarinen_HK
dc.subjectNew substituted 5-hydroxycoumarinen_HK
dc.subjectPyranocoumarinen_HK
dc.titleSynthesis and evaluation of novel substituted 5-hydroxycoumarin and pyranocoumarin derivatives exhibiting significant antiproliferative activity against breast cancer cell linesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0960-894X&volume=19&spage=4570&epage=4573&date=2009&atitle=Synthesis+and+evaluation+of+novel+substituted+5-hydroxycoumarin+and+pyranocoumarin+derivatives+exhibiting+significant+antiproliferative+activity+against+breast+cancer+cell+lines+en_HK
dc.identifier.emailChen, Jp: abchen@hku.hken_HK
dc.identifier.emailShen, Jg: shenjg@hku.hken_HK
dc.identifier.authorityChen, Jp=rp01316en_HK
dc.identifier.authorityShen, Jg=rp00487en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bmcl.2009.06.098en_HK
dc.identifier.pmid19616431-
dc.identifier.scopuseid_2-s2.0-67651092267en_HK
dc.identifier.hkuros160393en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67651092267&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue16en_HK
dc.identifier.spage4570en_HK
dc.identifier.epage4573en_HK
dc.identifier.isiWOS:000268358800009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMao, Ww=16239096200en_HK
dc.identifier.scopusauthoridWang, Tt=8834035200en_HK
dc.identifier.scopusauthoridZeng, Hp=7401472015en_HK
dc.identifier.scopusauthoridWang, Zy=7410038338en_HK
dc.identifier.scopusauthoridChen, Jp=22733695400en_HK
dc.identifier.scopusauthoridShen, Jg=7404929947en_HK
dc.identifier.issnl0960-894X-

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