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Article: Synthesis and evaluation of novel substituted 5-hydroxycoumarin and pyranocoumarin derivatives exhibiting significant antiproliferative activity against breast cancer cell lines

TitleSynthesis and evaluation of novel substituted 5-hydroxycoumarin and pyranocoumarin derivatives exhibiting significant antiproliferative activity against breast cancer cell lines
Authors
KeywordsAgainst breast cancer cell lines
Antiproliferative activity
Breast cancer
Hydroxycoumarin
New substituted 5-hydroxycoumarin
Pyranocoumarin
Issue Date2009
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/bmcl
Citation
Bioorganic And Medicinal Chemistry Letters, 2009, v. 19 n. 16, p. 4570-4573 How to Cite?
AbstractA library of novel 5-hydroxycoumarin and pyranocoumarin derivatives was constructed via silica sulfuric acid-catalyzed pechmann reaction and Pd(0)-catalyzed suzuki coupling in tandem, and their antiproliferative activities against breast cancer cells MCF-7 and MDA-MB-231 were evaluated. The results showed that compounds such as 6b, 6d, 6h, and 6k possess significant antiproliferative activity against MCF-7 cell line with the IC 50 values of 7.2, 5.3, 3.3, and 6.5 μM, respectively. © 2009 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89636
ISSN
2015 Impact Factor: 2.486
2015 SCImago Journal Rankings: 0.952
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China20671036
2007A010500008
2008B010800030
Funding Information:

Financial support from the National Natural Science Foundation of China (Nos. 20671036, 2007A010500008, and 2008B010800030) is gratefully acknowledged.

References

 

DC FieldValueLanguage
dc.contributor.authorMao, Wwen_HK
dc.contributor.authorWang, Tten_HK
dc.contributor.authorZeng, Hpen_HK
dc.contributor.authorWang, Zyen_HK
dc.contributor.authorChen, Jpen_HK
dc.contributor.authorShen, Jgen_HK
dc.date.accessioned2010-09-06T09:59:43Z-
dc.date.available2010-09-06T09:59:43Z-
dc.date.issued2009en_HK
dc.identifier.citationBioorganic And Medicinal Chemistry Letters, 2009, v. 19 n. 16, p. 4570-4573en_HK
dc.identifier.issn0960-894Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/89636-
dc.description.abstractA library of novel 5-hydroxycoumarin and pyranocoumarin derivatives was constructed via silica sulfuric acid-catalyzed pechmann reaction and Pd(0)-catalyzed suzuki coupling in tandem, and their antiproliferative activities against breast cancer cells MCF-7 and MDA-MB-231 were evaluated. The results showed that compounds such as 6b, 6d, 6h, and 6k possess significant antiproliferative activity against MCF-7 cell line with the IC 50 values of 7.2, 5.3, 3.3, and 6.5 μM, respectively. © 2009 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/bmclen_HK
dc.relation.ispartofBioorganic and Medicinal Chemistry Lettersen_HK
dc.subjectAgainst breast cancer cell linesen_HK
dc.subjectAntiproliferative activityen_HK
dc.subjectBreast canceren_HK
dc.subjectHydroxycoumarinen_HK
dc.subjectNew substituted 5-hydroxycoumarinen_HK
dc.subjectPyranocoumarinen_HK
dc.titleSynthesis and evaluation of novel substituted 5-hydroxycoumarin and pyranocoumarin derivatives exhibiting significant antiproliferative activity against breast cancer cell linesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0960-894X&volume=19&spage=4570&epage=4573&date=2009&atitle=Synthesis+and+evaluation+of+novel+substituted+5-hydroxycoumarin+and+pyranocoumarin+derivatives+exhibiting+significant+antiproliferative+activity+against+breast+cancer+cell+lines+en_HK
dc.identifier.emailChen, Jp: abchen@hku.hken_HK
dc.identifier.emailShen, Jg: shenjg@hku.hken_HK
dc.identifier.authorityChen, Jp=rp01316en_HK
dc.identifier.authorityShen, Jg=rp00487en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bmcl.2009.06.098en_HK
dc.identifier.pmid19616431-
dc.identifier.scopuseid_2-s2.0-67651092267en_HK
dc.identifier.hkuros160393en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67651092267&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue16en_HK
dc.identifier.spage4570en_HK
dc.identifier.epage4573en_HK
dc.identifier.isiWOS:000268358800009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMao, Ww=16239096200en_HK
dc.identifier.scopusauthoridWang, Tt=8834035200en_HK
dc.identifier.scopusauthoridZeng, Hp=7401472015en_HK
dc.identifier.scopusauthoridWang, Zy=7410038338en_HK
dc.identifier.scopusauthoridChen, Jp=22733695400en_HK
dc.identifier.scopusauthoridShen, Jg=7404929947en_HK

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