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Article: Effects of Buyang Huanwu Decoction on caveolin 1 and 2 of cerebral ischemia in rats

TitleEffects of Buyang Huanwu Decoction on caveolin 1 and 2 of cerebral ischemia in rats
補陽還五湯對局灶性腦缺血大鼠腦內caveolin1、2的影響
Authors
Liu, BYShen, JCai, GXXie, YChen, XMYang, Hui
KeywordsCerebral ischemic/TCM therapy
Caveolin1
Caveolin2
Buyang Huanwu decoction
Rats
Issue Date2008
Publisher湖南中醫藥大學. The Journal's web site is located at http://www.cnki.com.cn/Journal/E-E2-HNZX.htm
Citation
湖南中醫藥大學學報, 2008, v. 28 n. 1, p. 22-28 How to Cite?
Journal of Traditional Chinese Medicine University of Hunan, 2008, v. 28 n. 1, p. 22-28 How to Cite?
Abstract目的探討補陽還五湯對局灶性腦缺血大鼠腦內caveolin1、2的影響。方法采用大腦中動脈阻塞法復制腦缺血模型,將動物隨機分為正常組、假手術組、模型組、補陽還五湯組,分別給予不同處理,在12 h、1、3、7 d不同時間點處死動物,采用免疫組織化學法觀察caveolin1、2的表達。結果補陽還五湯能顯著減輕神經功能缺損;正常腦內有一定量的caveolin1、2表達,缺血后caveolin1、2迅速增加,分別于術后3 d或1 d達高峰,補陽還五湯組顯著提高caveolin1、2的表達,在3、7 d時模型組與補陽還五湯組差異有統計學意義(P<0.01)。結論補陽還五湯可調節腦缺血后caveolin1、2的表達,是其促進神經功能恢復的可能機制之一。 Objective To investigate the effects of Buyang Huanwu decoction(BYHW) on expression of caveolin1 and 2 of cerebral ischemia in rats.Methods Cerebral ischemia was induced by middle cerebral artery occlusion.The rats were randomly divided into four groups including naive,shame-operated,control and BYHW groups.All the rats were killed in 12 hours and 1,3 or 7day after operation.The expressions of caveolin1 and caveolin2 were measured by immunohistochemical staining.Results BYHW could reduce obviously the injury of nervous functions;expression of caveolin1 and 2 positive cells existed in normal brain,caveolin 1 or 2 were enhanced immediately after ischemia and reached to peak at 3 day or 1 day after ischemia respectively;BYHW could increase the number of caveolin1 and 2 positive cells at 3 and 7 day after ischemia and treatment(P<0.01).Conclusion BYHW is capable of regulating expression of caveolin1 and 2 in ischemic brain which may be one of anti-ischemic mechanism of the decoction.
Persistent Identifierhttp://hdl.handle.net/10722/89628
ISSN
1674-070X

 

DC FieldValueLanguage
dc.contributor.authorLiu, BYen_HK
dc.contributor.authorShen, Jen_HK
dc.contributor.authorCai, GX-
dc.contributor.authorXie, Y-
dc.contributor.authorChen, XM-
dc.contributor.authorYang, Hui-
dc.date.accessioned2010-09-06T09:59:36Z-
dc.date.available2010-09-06T09:59:36Z-
dc.date.issued2008en_HK
dc.identifier.citation湖南中醫藥大學學報, 2008, v. 28 n. 1, p. 22-28en_HK
dc.identifier.citationJournal of Traditional Chinese Medicine University of Hunan, 2008, v. 28 n. 1, p. 22-28-
dc.identifier.issn1674-070X-
dc.identifier.urihttp://hdl.handle.net/10722/89628-
dc.description.abstract目的探討補陽還五湯對局灶性腦缺血大鼠腦內caveolin1、2的影響。方法采用大腦中動脈阻塞法復制腦缺血模型,將動物隨機分為正常組、假手術組、模型組、補陽還五湯組,分別給予不同處理,在12 h、1、3、7 d不同時間點處死動物,采用免疫組織化學法觀察caveolin1、2的表達。結果補陽還五湯能顯著減輕神經功能缺損;正常腦內有一定量的caveolin1、2表達,缺血后caveolin1、2迅速增加,分別于術后3 d或1 d達高峰,補陽還五湯組顯著提高caveolin1、2的表達,在3、7 d時模型組與補陽還五湯組差異有統計學意義(P<0.01)。結論補陽還五湯可調節腦缺血后caveolin1、2的表達,是其促進神經功能恢復的可能機制之一。 Objective To investigate the effects of Buyang Huanwu decoction(BYHW) on expression of caveolin1 and 2 of cerebral ischemia in rats.Methods Cerebral ischemia was induced by middle cerebral artery occlusion.The rats were randomly divided into four groups including naive,shame-operated,control and BYHW groups.All the rats were killed in 12 hours and 1,3 or 7day after operation.The expressions of caveolin1 and caveolin2 were measured by immunohistochemical staining.Results BYHW could reduce obviously the injury of nervous functions;expression of caveolin1 and 2 positive cells existed in normal brain,caveolin 1 or 2 were enhanced immediately after ischemia and reached to peak at 3 day or 1 day after ischemia respectively;BYHW could increase the number of caveolin1 and 2 positive cells at 3 and 7 day after ischemia and treatment(P<0.01).Conclusion BYHW is capable of regulating expression of caveolin1 and 2 in ischemic brain which may be one of anti-ischemic mechanism of the decoction.-
dc.languagechien_HK
dc.publisher湖南中醫藥大學. The Journal's web site is located at http://www.cnki.com.cn/Journal/E-E2-HNZX.htm-
dc.relation.ispartof湖南中醫藥大學學報en_HK
dc.relation.ispartofJournal of Traditional Chinese Medicine University of Hunan-
dc.subjectCerebral ischemic/TCM therapy-
dc.subjectCaveolin1-
dc.subjectCaveolin2-
dc.subjectBuyang Huanwu decoction-
dc.subjectRats-
dc.titleEffects of Buyang Huanwu Decoction on caveolin 1 and 2 of cerebral ischemia in ratsen_HK
dc.title補陽還五湯對局灶性腦缺血大鼠腦內caveolin1、2的影響-
dc.typeArticleen_HK
dc.identifier.emailShen, J: shenjg@hkucc.hku.hken_HK
dc.identifier.authorityShen, J=rp00487en_HK
dc.identifier.hkuros145216en_HK
dc.identifier.volume28-
dc.identifier.issue1-
dc.identifier.spage22-
dc.identifier.epage28-
dc.publisher.placeChina-
dc.identifier.issnl1674-070X-

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