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Article: Thirsty heroin addicts show different fMRI activations when exposed to water-related and drug-related cues

TitleThirsty heroin addicts show different fMRI activations when exposed to water-related and drug-related cues
Authors
KeywordsAddiction
Craving
Drug-dependence
Functional MRI
Heroin
Opiate
Issue Date2006
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/drugalcdep
Citation
Drug And Alcohol Dependence, 2006, v. 83 n. 2, p. 157-162 How to Cite?
AbstractRelapse to drug use is frequently preceded or caused by craving, an intense desire for drug. Advances in functional brain imaging techniques make it possible to directly investigate this special mental state in vivo and non-invasively. Extant imaging studies on craving have been mostly on cocaine which is the dominant drug abused in the U.S. Employing functional MRI, we examined substance specificity of the neural circuitry underlying craving for heroin. Heroin is the primary drug abused in south-east Asia and has, particularly, become a serious social problem for China in recent years. Following abstinence from water and drug, 14 active heroin addicts (all male, mean age 33.2 years, average drug use history 7.1 years) underwent scanning inside a 1.5T Philips MR scanner during exposure to water-related, drug-related, and neutral cues. Water-related cues elicited anterior cingulate activation (Brodmann's area BA 32/24). Drug-related cues activated bilateral inferior frontal cortex (BA 44/45), confirming the critical role of prefrontal cortex in drug craving. Results suggest heroin craving may involve different neural substrates than do desire from basic physiological drives, such as thirst. As the first fMRI study of heroin craving, our study adds to the scant but much-needed brain imaging literature on heroin addiction. © 2005 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89532
ISSN
2015 Impact Factor: 3.349
2015 SCImago Journal Rankings: 1.785
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXiao, Zen_HK
dc.contributor.authorLee, Ten_HK
dc.contributor.authorZhang, JXen_HK
dc.contributor.authorWu, Qen_HK
dc.contributor.authorWu, Ren_HK
dc.contributor.authorWeng, Xen_HK
dc.contributor.authorHu, Xen_HK
dc.date.accessioned2010-09-06T09:58:13Z-
dc.date.available2010-09-06T09:58:13Z-
dc.date.issued2006en_HK
dc.identifier.citationDrug And Alcohol Dependence, 2006, v. 83 n. 2, p. 157-162en_HK
dc.identifier.issn0376-8716en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89532-
dc.description.abstractRelapse to drug use is frequently preceded or caused by craving, an intense desire for drug. Advances in functional brain imaging techniques make it possible to directly investigate this special mental state in vivo and non-invasively. Extant imaging studies on craving have been mostly on cocaine which is the dominant drug abused in the U.S. Employing functional MRI, we examined substance specificity of the neural circuitry underlying craving for heroin. Heroin is the primary drug abused in south-east Asia and has, particularly, become a serious social problem for China in recent years. Following abstinence from water and drug, 14 active heroin addicts (all male, mean age 33.2 years, average drug use history 7.1 years) underwent scanning inside a 1.5T Philips MR scanner during exposure to water-related, drug-related, and neutral cues. Water-related cues elicited anterior cingulate activation (Brodmann's area BA 32/24). Drug-related cues activated bilateral inferior frontal cortex (BA 44/45), confirming the critical role of prefrontal cortex in drug craving. Results suggest heroin craving may involve different neural substrates than do desire from basic physiological drives, such as thirst. As the first fMRI study of heroin craving, our study adds to the scant but much-needed brain imaging literature on heroin addiction. © 2005 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/drugalcdepen_HK
dc.relation.ispartofDrug and Alcohol Dependenceen_HK
dc.rightsDrug and Alcohol Dependence. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectAddictionen_HK
dc.subjectCravingen_HK
dc.subjectDrug-dependenceen_HK
dc.subjectFunctional MRIen_HK
dc.subjectHeroinen_HK
dc.subjectOpiateen_HK
dc.titleThirsty heroin addicts show different fMRI activations when exposed to water-related and drug-related cuesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0376-8716&volume=83&spage=157&epage=162&date=2006&atitle=Thirsty+heroin+addicts+show+different+fMRI+activations+when+exposed+to+water-related+and+drug-related+cuesen_HK
dc.identifier.emailLee, T:tmclee@hku.hken_HK
dc.identifier.authorityLee, T=rp00564en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.drugalcdep.2005.11.012en_HK
dc.identifier.pmid16406379-
dc.identifier.scopuseid_2-s2.0-33646898274en_HK
dc.identifier.hkuros119333en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646898274&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume83en_HK
dc.identifier.issue2en_HK
dc.identifier.spage157en_HK
dc.identifier.epage162en_HK
dc.identifier.isiWOS:000238702100008-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridXiao, Z=14044420000en_HK
dc.identifier.scopusauthoridLee, T=7501437381en_HK
dc.identifier.scopusauthoridZhang, JX=7601342094en_HK
dc.identifier.scopusauthoridWu, Q=55188356300en_HK
dc.identifier.scopusauthoridWu, R=8911019700en_HK
dc.identifier.scopusauthoridWeng, X=7102594100en_HK
dc.identifier.scopusauthoridHu, X=34770364200en_HK

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