File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals

TitleGray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals
Authors
KeywordsAddiction
Gray matter
Heroin
VBM
Issue Date2009
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/b&c
Citation
Brain And Cognition, 2009, v. 71 n. 3, p. 223-228 How to Cite?
AbstractNumerous studies have documented cognitive impairments and hypoactivity in the prefrontal and anterior cingulate cortices in drug users. However, the relationships between opiate dependence and brain structure changes in heroin users are largely unknown. In the present study, we measured the density of gray matter (DGM) with voxel-based morphometry in 30 lifetime heroin-dependent individuals who had abstained from drug use for 5 months, and 34 healthy participants. The DGM of the prefrontal, temporal and cingulate cortices significantly decreased in heroin addicts relative to the healthy group. Critically, partial correlation analysis, which controlled for age, education and gender factors as well as nicotine use and heroin abstinence duration, showed that the duration of heroin use negatively correlated with the DGM in heroin-dependent individuals. These results provide compelling evidence for structural abnormality in heroin-dependent individuals and further suggest that duration of heroin use is a critical factor leading to brain damage. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89523
ISSN
2015 Impact Factor: 2.399
2015 SCImago Journal Rankings: 1.511
ISI Accession Number ID
Funding AgencyGrant Number
China Ministry of Science and Technology2007CB512300
National Science Foundation of China30670674
Funding Information:

This work was supported by the China Ministry of Science and Technology (No. 2007CB512300) and the National Science Foundation of China (No. 30670674). We thank Dr. Baohua Zhang for his help in recruitment of the subjects and Dr. Yufeng Zang for his comments oil an earlier version of this manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorYuan, Yen_HK
dc.contributor.authorZhu, Zen_HK
dc.contributor.authorShi, Jen_HK
dc.contributor.authorZou, Zen_HK
dc.contributor.authorYuan, Fen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorWeng, Xen_HK
dc.date.accessioned2010-09-06T09:58:06Z-
dc.date.available2010-09-06T09:58:06Z-
dc.date.issued2009en_HK
dc.identifier.citationBrain And Cognition, 2009, v. 71 n. 3, p. 223-228en_HK
dc.identifier.issn0278-2626en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89523-
dc.description.abstractNumerous studies have documented cognitive impairments and hypoactivity in the prefrontal and anterior cingulate cortices in drug users. However, the relationships between opiate dependence and brain structure changes in heroin users are largely unknown. In the present study, we measured the density of gray matter (DGM) with voxel-based morphometry in 30 lifetime heroin-dependent individuals who had abstained from drug use for 5 months, and 34 healthy participants. The DGM of the prefrontal, temporal and cingulate cortices significantly decreased in heroin addicts relative to the healthy group. Critically, partial correlation analysis, which controlled for age, education and gender factors as well as nicotine use and heroin abstinence duration, showed that the duration of heroin use negatively correlated with the DGM in heroin-dependent individuals. These results provide compelling evidence for structural abnormality in heroin-dependent individuals and further suggest that duration of heroin use is a critical factor leading to brain damage. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/b&cen_HK
dc.relation.ispartofBrain and Cognitionen_HK
dc.subjectAddictionen_HK
dc.subjectGray matteren_HK
dc.subjectHeroinen_HK
dc.subjectVBMen_HK
dc.subject.meshCerebral Cortex - anatomy and histology-
dc.subject.meshDrug Users-
dc.subject.meshHeroin - administration and dosage-
dc.subject.meshHeroin Dependence-
dc.subject.meshAddiction-
dc.titleGray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individualsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-2626&volume=71&issue=3&spage=223&epage=228&date=2009&atitle=Gray+matter+density+negatively+correlates+with+duration+of+heroin+use+in+young+lifetime+heroin-dependent+individualsen_HK
dc.identifier.emailLee, TMC:tmclee@hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bandc.2009.08.014en_HK
dc.identifier.pmid19775795-
dc.identifier.scopuseid_2-s2.0-70350347478en_HK
dc.identifier.hkuros169542en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350347478&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume71en_HK
dc.identifier.issue3en_HK
dc.identifier.spage223en_HK
dc.identifier.epage228en_HK
dc.identifier.isiWOS:000271664400006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuan, Y=7402709080en_HK
dc.identifier.scopusauthoridZhu, Z=23487522400en_HK
dc.identifier.scopusauthoridShi, J=35218268200en_HK
dc.identifier.scopusauthoridZou, Z=35218554000en_HK
dc.identifier.scopusauthoridYuan, F=40262788800en_HK
dc.identifier.scopusauthoridLiu, Y=35262448100en_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.scopusauthoridWeng, X=7102594100en_HK
dc.identifier.citeulike5873661-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats