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Article: Gray matter reduction associated with emotion regulation in female outpatients with major depressive disorder: A voxel-based morphometry study

TitleGray matter reduction associated with emotion regulation in female outpatients with major depressive disorder: A voxel-based morphometry study
Authors
KeywordsAnterior cingulate cortex
Depression
Emotion regulation
Orbitofrontal region
Vowel-based morphometry
Issue Date2009
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbp
Citation
Progress In Neuro-Psychopharmacology And Biological Psychiatry, 2009, v. 33 n. 7, p. 1184-1190 How to Cite?
AbstractObjective: Though emotion dysregulation is the key feature in major depressive disorder, and structural changes in brain areas of depressed patients have been found, it is unknown how these regional volume alterations correlate with the ability to regulate emotion in the depressed population. Method: We examined the gray matter concentration (GMC) and volume (GMV) in 17 depressed patients and 17 healthy volunteers using a voxel-based morphometry (VBM) study. Images were acquired using a 1.5 T MRI scanner, and were spatially normalized and segmented. Statistical comparisons were performed using the general linear model. The identified volumetric alterations in the depressed participants were correlated with their performance on an emotion regulation task that involved reduction of positive or negative emotions to emotional pictures that were selected according to their individual ratings. Results: The depressed participants showed specific difficulty in regulating negative emotion, though not positive emotion, which was associated with reduced GMV and concentration in the anterior cingulate cortex (ACC) and the inferior orbitofrontal cortex (OFC). Decreased GMC in the superior temporal cortex was also found in people with major depressive disorder. Conclusions: Abnormal structures in the ACC and OFC and the dysregulation of negative emotion may relate to the pathology of major depressive disorder. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89515
ISSN
2015 Impact Factor: 4.361
2015 SCImago Journal Rankings: 1.794
ISI Accession Number ID
Funding AgencyGrant Number
The University of Hong Kong
National Natural Science Foundation of China30828012
Funding Information:

This project was supported by the Research Output Prize of The University of Hong Kong and the National Natural Science Foundation of China (#30828012).

References

 

DC FieldValueLanguage
dc.contributor.authorMak, AKYen_HK
dc.contributor.authorWong, MMCen_HK
dc.contributor.authorHan, Shen_HK
dc.contributor.authorLee, TMCen_HK
dc.date.accessioned2010-09-06T09:58:00Z-
dc.date.available2010-09-06T09:58:00Z-
dc.date.issued2009en_HK
dc.identifier.citationProgress In Neuro-Psychopharmacology And Biological Psychiatry, 2009, v. 33 n. 7, p. 1184-1190en_HK
dc.identifier.issn0278-5846en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89515-
dc.description.abstractObjective: Though emotion dysregulation is the key feature in major depressive disorder, and structural changes in brain areas of depressed patients have been found, it is unknown how these regional volume alterations correlate with the ability to regulate emotion in the depressed population. Method: We examined the gray matter concentration (GMC) and volume (GMV) in 17 depressed patients and 17 healthy volunteers using a voxel-based morphometry (VBM) study. Images were acquired using a 1.5 T MRI scanner, and were spatially normalized and segmented. Statistical comparisons were performed using the general linear model. The identified volumetric alterations in the depressed participants were correlated with their performance on an emotion regulation task that involved reduction of positive or negative emotions to emotional pictures that were selected according to their individual ratings. Results: The depressed participants showed specific difficulty in regulating negative emotion, though not positive emotion, which was associated with reduced GMV and concentration in the anterior cingulate cortex (ACC) and the inferior orbitofrontal cortex (OFC). Decreased GMC in the superior temporal cortex was also found in people with major depressive disorder. Conclusions: Abnormal structures in the ACC and OFC and the dysregulation of negative emotion may relate to the pathology of major depressive disorder. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbpen_HK
dc.relation.ispartofProgress in Neuro-Psychopharmacology and Biological Psychiatryen_HK
dc.subjectAnterior cingulate cortexen_HK
dc.subjectDepressionen_HK
dc.subjectEmotion regulationen_HK
dc.subjectOrbitofrontal regionen_HK
dc.subjectVowel-based morphometryen_HK
dc.subject.meshBrain - pathology-
dc.subject.meshDepressive Disorder, Major - pathology - physiopathology-
dc.subject.meshEmotions - physiology-
dc.subject.meshExpressed Emotion - physiology-
dc.subject.meshAnterior cingulate cortex-
dc.titleGray matter reduction associated with emotion regulation in female outpatients with major depressive disorder: A voxel-based morphometry studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-5846&volume=33&issue=7&spage=1184&epage=1190&date=2009&atitle=Gray+matter+reduction+associated+with+emotion+regulation+in+female+outpatients+with+major+depressive+disorder:+a+voxel-based+morphometry+studyen_HK
dc.identifier.emailLee, TMC:tmclee@hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.pnpbp.2009.06.025en_HK
dc.identifier.pmid19596037-
dc.identifier.scopuseid_2-s2.0-69349099444en_HK
dc.identifier.hkuros169543en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69349099444&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1184en_HK
dc.identifier.epage1190en_HK
dc.identifier.isiWOS:000270285500014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMak, AKY=7103123344en_HK
dc.identifier.scopusauthoridWong, MMC=25960495800en_HK
dc.identifier.scopusauthoridHan, Sh=7405942378en_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.citeulike5344585-

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