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Article: Neural correlates of Traditional Chinese Medicine induced advantageous risk-taking decision making

TitleNeural correlates of Traditional Chinese Medicine induced advantageous risk-taking decision making
Authors
KeywordsAnterior cingulate cortex
Balloon Analogue Risk Task
Insula
Prefrontal cortex
Risk taking
Striatum
Traditional Chinese Medicine
Issue Date2009
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/b&c
Citation
Brain And Cognition, 2009, v. 71 n. 3, p. 354-361 How to Cite?
AbstractThis fMRI study examined the neural correlates of the observed improvement in advantageous risk-taking behavior, as measured by the number of adjusted pumps in the Balloon Analogue Risk Task (BART), following a 60-day course of a Traditional Chinese Medicine (TCM) recipe, specifically designed to regulate impulsiveness in order to modulate risk-taking behavior. The 14 participants recruited for this study were randomly assigned to the experimental and control groups and the TCM recipe (Panax, 520 mg; Astragalus membranaceous Bunge, 520 mg; Masnetitum, 840 mg; Ostrea gigas Thumb, 470 mg; Thinleaf Milkwort Root Radix Polygalae, 450 mg; and Os Draconis, 470 mg) was administered, as a diet supplement, to the seven participants in the experimental group. The neural activity of the two groups was monitored by a 3T MRI scanner, before and after the 60-day treatment. Associated with the improved advantageous risk-taking behavior seen in the experimental group, significantly stronger blood oxygenation level dependent (BOLD) responses were observed in the bilateral dorsolateral prefrontal cortex (DLPFC), left putamen, left thalamus, right insula, and right anterior cingulate cortex (ACC), regions which have previously been reported as being involved in risk-taking decision making. The effect of the TCM in improving advantageous risk-taking decision making appears to have been related to the enhanced efficiency of the cognitive affective system, the PFC-ACC-insula-striatum network, which functions to inhibit impulsiveness, to sensitize reward-related information, and to allow the opportunity, during risk estimation, to evaluate potential gains and losses. The findings of this study suggest that interventions acting on factors modulating risk-taking decision making could have a beneficial effect in terms of optimizing risk-taking behavior. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89493
ISSN
2015 Impact Factor: 2.399
2015 SCImago Journal Rankings: 1.511
ISI Accession Number ID
Funding AgencyGrant Number
The University of Hong Kong
National Natural Science Foundation of China30828012
The Hong Kong Polytechnic University
Funding Information:

This project was supported by the Research Output Prize of The University of Hong Kong, Collaboration Research Award of the National Natural Science Foundation of China (#30828012), and the Niche Area Research Grant on "Training and Research on Chinese Astronauts" of The Hong Kong Polytechnic University.

References

 

DC FieldValueLanguage
dc.contributor.authorLee, TMYen_HK
dc.contributor.authorGuo, Lgen_HK
dc.contributor.authorShi, Hzen_HK
dc.contributor.authorLi, Yzen_HK
dc.contributor.authorLuo, Yjen_HK
dc.contributor.authorSung, CYYen_HK
dc.contributor.authorChan, CCHen_HK
dc.contributor.authorLee, TMCen_HK
dc.date.accessioned2010-09-06T09:57:44Z-
dc.date.available2010-09-06T09:57:44Z-
dc.date.issued2009en_HK
dc.identifier.citationBrain And Cognition, 2009, v. 71 n. 3, p. 354-361en_HK
dc.identifier.issn0278-2626en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89493-
dc.description.abstractThis fMRI study examined the neural correlates of the observed improvement in advantageous risk-taking behavior, as measured by the number of adjusted pumps in the Balloon Analogue Risk Task (BART), following a 60-day course of a Traditional Chinese Medicine (TCM) recipe, specifically designed to regulate impulsiveness in order to modulate risk-taking behavior. The 14 participants recruited for this study were randomly assigned to the experimental and control groups and the TCM recipe (Panax, 520 mg; Astragalus membranaceous Bunge, 520 mg; Masnetitum, 840 mg; Ostrea gigas Thumb, 470 mg; Thinleaf Milkwort Root Radix Polygalae, 450 mg; and Os Draconis, 470 mg) was administered, as a diet supplement, to the seven participants in the experimental group. The neural activity of the two groups was monitored by a 3T MRI scanner, before and after the 60-day treatment. Associated with the improved advantageous risk-taking behavior seen in the experimental group, significantly stronger blood oxygenation level dependent (BOLD) responses were observed in the bilateral dorsolateral prefrontal cortex (DLPFC), left putamen, left thalamus, right insula, and right anterior cingulate cortex (ACC), regions which have previously been reported as being involved in risk-taking decision making. The effect of the TCM in improving advantageous risk-taking decision making appears to have been related to the enhanced efficiency of the cognitive affective system, the PFC-ACC-insula-striatum network, which functions to inhibit impulsiveness, to sensitize reward-related information, and to allow the opportunity, during risk estimation, to evaluate potential gains and losses. The findings of this study suggest that interventions acting on factors modulating risk-taking decision making could have a beneficial effect in terms of optimizing risk-taking behavior. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/b&cen_HK
dc.relation.ispartofBrain and Cognitionen_HK
dc.subjectAnterior cingulate cortexen_HK
dc.subjectBalloon Analogue Risk Tasken_HK
dc.subjectInsulaen_HK
dc.subjectPrefrontal cortexen_HK
dc.subjectRisk takingen_HK
dc.subjectStriatumen_HK
dc.subjectTraditional Chinese Medicineen_HK
dc.subject.meshAdult-
dc.subject.meshBrain - drug effects - physiology-
dc.subject.meshDecision Making - drug effects - physiology-
dc.subject.meshDrugs, Chinese Herbal - administration and dosage-
dc.subject.meshRisk-Taking-
dc.titleNeural correlates of Traditional Chinese Medicine induced advantageous risk-taking decision makingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-2626&volume=71&issue=3&spage=354&epage=361&date=2009&atitle=Neural+correlates+of+traditional+Chinese+Medicine+induced+advantageous+risk-taking+decision+makingen_HK
dc.identifier.emailLee, TMC:tmclee@hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bandc.2009.06.006en_HK
dc.identifier.pmid19679384-
dc.identifier.scopuseid_2-s2.0-70350287311en_HK
dc.identifier.hkuros169541en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350287311&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume71en_HK
dc.identifier.issue3en_HK
dc.identifier.spage354en_HK
dc.identifier.epage361en_HK
dc.identifier.isiWOS:000271664400024-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLee, TMY=36637725800en_HK
dc.identifier.scopusauthoridGuo, Lg=35218848000en_HK
dc.identifier.scopusauthoridShi, Hz=7402623352en_HK
dc.identifier.scopusauthoridLi, Yz=36062875400en_HK
dc.identifier.scopusauthoridLuo, Yj=7404332638en_HK
dc.identifier.scopusauthoridSung, CYY=7202124568en_HK
dc.identifier.scopusauthoridChan, CCH=16244174500en_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.citeulike5519729-

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