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Article: Pathophysiological mechanism of seasonal affective disorder

TitlePathophysiological mechanism of seasonal affective disorder
Authors
Issue Date1997
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jad
Citation
Journal Of Affective Disorders, 1997, v. 46 n. 1, p. 25-38 How to Cite?
AbstractDespite the long history in medicine, the pathophysiological mechanism(s) of seasonal affective disorder (SAD) remain largely unknown. By employing a meta-analytic methodology, the authors of this study attempted to verify the validity of different pathophysiological mechanism(s) proposed for SAD. The findings showed that for phototherapy of medium light intensity, a combination of morning-evening therapy regime yielded the best therapeutic effect, and the antidepressant effect of the morning-evening light regime was superior to a single pulse of light administered at other times of day. Furthermore, the data showed that the antidepressant effect of a single pulse of light was similar for morning, midday, and evening light. These findings supported the photon-count hypothesis and refuted the proposed photoperiod, melatonin, and phase-shifting models of SAD.
Persistent Identifierhttp://hdl.handle.net/10722/89451
ISSN
2015 Impact Factor: 3.57
2015 SCImago Journal Rankings: 1.927
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorBlashko, CAen_HK
dc.contributor.authorJanzen, HLen_HK
dc.contributor.authorPaterson, JGen_HK
dc.contributor.authorChan, CCHen_HK
dc.date.accessioned2010-09-06T09:57:11Z-
dc.date.available2010-09-06T09:57:11Z-
dc.date.issued1997en_HK
dc.identifier.citationJournal Of Affective Disorders, 1997, v. 46 n. 1, p. 25-38en_HK
dc.identifier.issn0165-0327en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89451-
dc.description.abstractDespite the long history in medicine, the pathophysiological mechanism(s) of seasonal affective disorder (SAD) remain largely unknown. By employing a meta-analytic methodology, the authors of this study attempted to verify the validity of different pathophysiological mechanism(s) proposed for SAD. The findings showed that for phototherapy of medium light intensity, a combination of morning-evening therapy regime yielded the best therapeutic effect, and the antidepressant effect of the morning-evening light regime was superior to a single pulse of light administered at other times of day. Furthermore, the data showed that the antidepressant effect of a single pulse of light was similar for morning, midday, and evening light. These findings supported the photon-count hypothesis and refuted the proposed photoperiod, melatonin, and phase-shifting models of SAD.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jaden_HK
dc.relation.ispartofJournal of Affective Disordersen_HK
dc.rightsJournal of Affective Disorders. Copyright © Elsevier BV.en_HK
dc.titlePathophysiological mechanism of seasonal affective disorderen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0165-0327&volume=&spage=&epage=&date=1997&atitle=Pathophysiological+Mechanisms+of+Seasonal+Affective+Disorderen_HK
dc.identifier.emailLee, TMC:tmclee@hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0165-0327(97)00076-1en_HK
dc.identifier.pmid9387084-
dc.identifier.scopuseid_2-s2.0-0030832947en_HK
dc.identifier.hkuros23642en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030832947&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue1en_HK
dc.identifier.spage25en_HK
dc.identifier.epage38en_HK
dc.identifier.isiWOS:A1997YE66400003-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.scopusauthoridBlashko, CA=7801357379en_HK
dc.identifier.scopusauthoridJanzen, HL=7005291726en_HK
dc.identifier.scopusauthoridPaterson, JG=7202532461en_HK
dc.identifier.scopusauthoridChan, CCH=16244174500en_HK

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